Grape and its derived products contain a wide range of polyphenolic compounds that have been shown to possess anti-inflammatory activities, and to prevent cellular deterioration that predisposes to atherosclerosis and coronary heart disease, therefore, these compounds are considered as bioactive compounds having beneficial effects on human health (Rasines-Perea & Teissedre, 2017; Zuanazzi et al., 2019). Moreover, the compounds found in grape and its by-products have positive effects on health and can be found in any part of the fruit (skin, pulp, and seeds) and they include flavonoids (anthocyanins, flavanols, and flavonols), phenolic acids, and stilbenes (Samoticha et al., 2017). On the contrary, grapes are highly appreciated for their sugar content, especially glucose and fructose, the main sugars that are related to juices' quality (Eyduran, Akin, Ercisli, Eyduran, & Maghradze, 2015). The concentration of bioactive compounds and sugars in grape depend mainly on factors such as ripening stage, variety, region of origin, climate, cultural practices, and process conditions (Lima et al., 2015). In the last decades, demand and consumption of freshly squeezed fruit juices with unimpaired sensory and nutritional qualities, also