The purpose is to establish Mass Customization (MC)-oriented Customer Demand Response (CDR) service platform based on Cloud Computing (CC) and the Internet of Things (IoT). Firstly, the MCoriented Demand Response (DR) process and the characteristics of CC are analyzed. Secondly, an MCoriented CDR service platform system based on CC and IoT is proposed. Finally, the edge-cloud collaborative computing method is used to maintain the efficiency and stability of the CC platform, and the proposed method is compared with other state-of-art algorithms to further prove its effectiveness. The results show that the parameters φ and V have a significant impact on the queue size and operation cost. Compared with other methods, the operation cost of the proposed edge-cloud collaborative computing method is relatively low. Thus, the proposed edge-cloud collaborative computing method is more applicable in high-speed and low-speed data; it can also improve the resource utilization of the Data Center (DC) and reduce the operation cost. The research results provide a basis for the establishment of the MCoriented CDR service platform.