Process intensification with biocatalysts: dynamic kinetic resolution and fluorous phase switch with continuous extraction

Teo, Ee-Ling; Chuah, Gaik‐Khuan; Huguet, Arnaud; Jaenicke, Stephan; Pande, G. B.; Zhu, Yamei

doi:10.1016/j.cattod.2004.07.008

Cited by 23 publications

(10 citation statements)

References 42 publications

(44 reference statements)

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“…Therefore, to compare the batch and continuous-flow processes, the experiments herein were conducted with a substrate concentration of 150 mM for both of the processes and the values at 50% conversion were used for the productivity calculations (Eqs. 7and (8)). According to the results, productivity in the continuous-flow mode (1.341 mmol/min/g) was higher than that of the batch mode (0.363 mmol/min/g) by approximately 4 times (Table).…”

Section: Productivitymentioning

confidence: 99%

“…To compare the batch and continuous-flow processes of the transesterification of (R,S)-2-pentanol, productivities were calculated from Eqs. (7) and (8), where C P , Q, n, and t represent the product ((R)-2-pentyl butyrate) concentration, volumetric flow rate, mole of the product ((R)-2-pentyl butyrate),and reaction time, respectively. For batch process in which the same immobilized enzyme was used, the values were taken from previous work [3].…”

Section: Productivitymentioning

confidence: 99%

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Mathematical modeling of a continuous-flow packed-bed reactor with immobilized lipase for kinetic resolution of (R,S)-2-pentanol

Malyemez¹,

Gıwa²,

Bayraktar³

et al. 2020

Turk J Chem

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In this study, the kinetic resolution of (R,S)-2-pentanol via transesterification to achieve S-2-pentanol, a key intermediate required in the synthesis of anti-Alzheimer drugs, was investigated in continuous-flow packed-bed reactors. The effects of residence time, substrate concentration, and operation time of the enzyme were investigated. Under steady state conditions, 50% conversion and enantiomeric excess of the substrate (eeS)>99% were achieved at a residence time of 0.04 min. Productivity of the continuous-flow process (1.341 mmol/min/g)was about 4 times higher than that of the corresponding batch process (0.363 mmol/min/g). In addition, the mathematical modeling of the packed-bed reactor was conductedusing an axial dispersion model. Ping Pong Bi Bi kinetics was used in this model. Design parameters were determined and the developed equations were solved using an algorithm for solving boundary value problems for ordinary differential equations by collocation (bvp4c) using MATLAB. The results, obtained from the model, fitted the experimental data very well.

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Section: Productivitymentioning

confidence: 99%

Section: Productivitymentioning

confidence: 99%

Mathematical modeling of a continuous-flow packed-bed reactor with immobilized lipase for kinetic resolution of (R,S)-2-pentanol

Malyemez¹,

Gıwa²,

Bayraktar³

et al. 2020

Turk J Chem

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show abstract

“…Theil et al [62] subsequently described a fluorous alkyl transfer reagent, 2¢,2¢,2¢-trifluoroethyl-2H,2H,3H,3H-perfluorododecanoate 9, which was compatible with a lipase catalyzed kinetic resolution. We investigated this system with the intention to develop a scaleable process for extractive separation [63]. Using Theil's fluorous acyl-transfer reagent 9, the lipase acylates preferentially the (R)-isomer of 1-phenylethanol.…”

Section: Separation In Fluorous Medium and Membrane Assisted Extractionmentioning

confidence: 99%

Characterization of Heterogeneous Catalysts by use of Test Reactions

Jaenicke

2005

Catal Surv Asia

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The following report gives an overview on work done in the Catalysis Laboratory of the Department of Chemistry, National University of Singapore over the last 15 years (1989)(1990)(1991)(1992)(1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004). Much of this work can be described as ''characterization of catalytically active surfaces through test reactions''. The methods, systems studied and the reactions that we evaluated will be described. The review will mostly concentrate on work from the authors' laboratory, but other relevant work will also be cited.

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“…Enzyme catalysis of kinetic separation and asymmetric organic molecule synthesis to extract pure molecules has also been accelerated in the recent past. They are exploited to synthesize chiral molecules during the past decade due to the greater enantioselectivity [13,14]. They are promising in the field of Green Chemistry mainly for the synthesis of chiral molecules, food additives or many drugs under the gentle eco-friendly conditions [15].…”

Section: Introductionmentioning

confidence: 99%

Enzymes’ action on materials: Recent trends

Khan

Dutta

Ganesan

2016

JCB

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In the era of increasing usage of materials, there is a growing concern of environmental aspects. This has motivated many scientists to research on greener materials and technologies. In this line, several biodegradable materials and biomolecules-based technologies have been developed in the recent years. This has triggered vivacious participation of various biomolecules such as DNA, proteins, enzymes, and cells in the field of 'materials'. Among the various biomolecules, enzymes have gained a significant position due to their applications in numerous fields including nanoparticles synthesis, polymer degradation, enzymatic lithography, biosensing and bio-fuel cells. This mini-review accounts on recent trends in selective fields such as nanoparticles synthesis, enzymatic polymer degradation and enzymatic lithography.

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Process intensification with biocatalysts: dynamic kinetic resolution and fluorous phase switch with continuous extraction

Cited by 23 publications

References 42 publications

Mathematical modeling of a continuous-flow packed-bed reactor with immobilized lipase for kinetic resolution of (R,S)-2-pentanol

Mathematical modeling of a continuous-flow packed-bed reactor with immobilized lipase for kinetic resolution of (R,S)-2-pentanol

Characterization of Heterogeneous Catalysts by use of Test Reactions

Enzymes’ action on materials: Recent trends

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