Proceedings of a Consensus Conference: Towards an Understanding of TRALI

Goldman, Mindy; Webert, Kathryn E.; Arnold, Donald M.; Freedman, J.; Hannon, Judith; Blajchman, Morris A.

doi:10.1016/j.tmrv.2004.10.001

Cited by 316 publications

(329 citation statements)

References 30 publications

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“…[1][2][3][4] TRALI is defined as the acute onset of hypoxia and bilateral pulmonary infiltrates, in temporal relation to a blood transfusion. 1,5 Although the absence of specific disease markers and diagnostic tests has resulted in a large variation in estimations of incidence, 1,[6][7][8][9][10][11][12][13][14] TRALI is generally considered to be a rare event. However, TRALI is underdiagnosed and under-reported.…”

Section: Introductionmentioning

confidence: 99%

The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested case-control study

Vlaar

Hofstra²,

Determann³

et al. 2011

Blood

184

176

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Section: Introductionmentioning

confidence: 99%

The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested case-control study

Vlaar

Hofstra²,

Determann³

et al. 2011

Blood

184

176

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“…Считается, что острое повреждение легочной ткани при переливании крови происходит за счет острой гипоксии с последующей клеточной инфильтрацией обоих легких во время гемо-трансфузии [11,23]. Описаны два механизма этого про-цесса: 1) при наличии хронического воспаления в легоч-ной ткани при гемотрансфузии происходит активация нейтрофилов и увеличение их тропности к эндотелию, в результате чего поражается легкое, имеющее большое число мелких сосудов [5]; 2) в переливаемой крови содер-жатся различные антитела и цитокины, которые накапли-ваются в процессе хранения, при взаимодействии их с нейтрофилами крови реципиента происходит активация последних, что клинически проявляется отеком легких Рис.…”

Section: Discussionunclassified

Prediction and prevention of pulmonary-pleural complications after heart valve surgery

Belov¹,

Katkov²,

Винокуров³

2015

Kardiol. serdechno-sosud. khir.

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Топографоанатомические особенности расположения сердца, его близкое взаиморасположение с легкими опреде-ляют высокую частоту развития легочных осложнений после операций на сердце. Вскрытие плевральной полости, изме-нение перфузии легочной ткани во время искусственного кровообращения (ИК), нарушение целостности каркаса грудной клетки лежат в основе патогенеза послеоперацион-ных легочно-плевральных осложнений. Частота таких ос-ложнений после вмешательств на открытом сердце состав-ляет 6-76% [4,7]. При развитии выраженной дыхательной недостаточности (ДН) требуется продленная вентиляция легких, что увеличивает сроки нахождения пациента в отде-лении реанимации и, соответственно, в стационаре [10]. Вы-пот в плевральную полость является наиболее частым ос-ложнением этой категории, которое не вызывает трудностей в диагностике, но требует выполнения торакоцентеза.Цель исследования -рассмотреть два зависимых от операции осложнения: дыхательную недостаточность, требующую продленной вентиляции легких, и выпот в плевральную полость. .3 min) also were noted in the main group. Encephalopathy has been developed significantly more frequent in these patients (57.9% vs. 1.5%), and there was higher mortality (42.1% vs. 0) in comparison with the control group. It is noted that preoperative reduction of lungs vital capacity to 80% increases incidence of complications. It is evaluated the causes of postoperative exudative pleurisy. Postoperative minimal levels of serum total protein (60 g/l) and albumin (34 g/l) after surgery were defined as predictors of 3 times increasing of hydrothorax.

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“…7,18 According to data reported by the Canadian Blood Services at the Canadian Consensus Conference, mortality from TRALI was 17%. 19 Data from the Food and Drug Administration evaluating transfusion related fatalities from 2001 to 2003, 19 showed that TRALI had emerged as the leading cause of transfusion-related death accounting for 16.3% of transfusion deaths followed by ABO incompatibility and bacterial contamination.…”

Section: Discussionmentioning

confidence: 99%

“…In the United Kingdom (UK), TRALI implicated blood products were 47% attributable to plasma-rich products including fresh frozen plasma, cryosupernatant and platelets even though these products represented only 25% of all blood products issued. 19 As of 2003, the National Blood Service in the UK moved to predominantly male plasma for transfusion, thereby minimizing plasmacontaining products from female donors at higher risk of developing leukocyte antibodies due to prior pregnancy. In November 2006, the AABB (formerly known as American Association of Blood Banks) published recommendations A to minimize high-plasma volume blood component production from donors who are known to be leukocyte immunized or at high risk of leukocyte alloimmunization.…”

Section: Discussionmentioning

confidence: 99%

Présentation de cas : lésion pulmonaire aiguë associée à la transfusion (TRALI) — Un danger net et présent

Lin

Kanani

Naughton

et al. 2007

Can J Anesth/J Can Anesth

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Purpose: To describe a case of transfusion-related acute lung injury (TRALI) after platelet transfusion immediately following cardiac surgery, and to review the clinical features, pathophysiology, management, and morbidity and mortality associated with such an event.Clinical features: A 62-yr-old man was transferred to our centre for urgent coronary artery bypass grafting in the setting of recent anti-platelet medication use. Soon after surgery he received platelet transfusions despite having only moderate blood loss. Shortly following the platelet transfusion, he suffered acute hypoxic and hypotensive decompensation requiring nitric oxide therapy, inotropic support, and prolonged need for mechanical ventilation. The patient was eventually discharged from the intensive care unit nine days following the event. The diagnosis of TRALI was made by clinical and radiographic criteria. Conclusion:Transfusion-related acute lung injury is now the leading cause of transfusion-related fatalities. Early diagnosis of TRALI is important and these reactions should be reported to the blood transfusion service so that appropriate action can be taken to prevent future morbidity and mortality in other patients. To reduce serious transfusion reactions, inappropriate transfusions must be minimized and the decision to transfuse blood products should be taken with care.

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Proceedings of a Consensus Conference: Towards an Understanding of TRALI

Cited by 316 publications

References 30 publications

The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested case-control study

The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested case-control study

Prediction and prevention of pulmonary-pleural complications after heart valve surgery

Présentation de cas : lésion pulmonaire aiguë associée à la transfusion (TRALI) — Un danger net et présent

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