Probiotics Supplementation Therapy for Pathological Neonatal Jaundice: A Systematic Review and Meta-Analysis

Chen, Zhe; Zhang, Lingli; Zeng, Linan; Yang, Xiaoyan; Jiang, Lucan; Gui, Ge; Zhang, Zuojie

doi:10.3389/fphar.2017.00432

Cited by 35 publications

(35 citation statements)

References 18 publications

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“…However, due to the single time point of sample collection in this study, we could only confirm the correlation between B. pseudolongum and ɑ-diversity, but not causality. We should notice that clinicians are using probiotic supplementation including Bifidobacterium to prevent and treat neonatal jaundice around the world 29 . Two meta-analyses on randomized controlled trials of probiotics therapy for the management of neonatal jaundice conservatively concluded that probiotic supplementation could be effective in treating neonatal jaundice 29 , 30 .…”

Section: Discussionmentioning

confidence: 99%

“…We should notice that clinicians are using probiotic supplementation including Bifidobacterium to prevent and treat neonatal jaundice around the world 29 . Two meta-analyses on randomized controlled trials of probiotics therapy for the management of neonatal jaundice conservatively concluded that probiotic supplementation could be effective in treating neonatal jaundice 29 , 30 . Large population-based longitudinal time-series studies are needed to confirm the causal association among B. pseudolongum , ɑ-diversity and neonatal jaundice.…”

Section: Discussionmentioning

confidence: 99%

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Meconium microbiome associates with the development of neonatal jaundice

Dong

Chen

White

et al. 2018

Clinical and Translational Gastroenterology

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ObjectiveNeonatal jaundice is a common disease that affects up to 60% of newborns. Gut microbiota mediated the excretion of bilirubin from the human body. However, the relationship between early gut microbiome and development of neonatal jaundice is not fully understood. Here we sought to characterize meconium microbiome of newborns and to clarify its association with risk of neonatal jaundice.MethodsWe conducted a nested case–control study with 301 newborns providing meconium samples from 2014 to 2015. The main outcome was the development of neonatal jaundice at 42 day follow-up. 16S rRNA gene sequencing was performed to profile the meconium microbiome. LEfSe was employed to identify different features between control and case groups. Logistic regression was used to estimate the risk effect of early gut microbiome on neonatal jaundice.ResultsLogistic regression models suggested that higher ɑ-diversity was significantly associated with lower risk of jaundice in cesarean infants (OR 0.72, 95% CI 0.52–0.98), but not in infants born naturally. Higher relative abundance of Bifidobacterium pseudolongum in newborn meconium was significantly associated with lower risk of jaundice both in cesarean-born infants and in the total subjects (OR 0.24, 95% CI 0.07–0.68; OR 0.55, 95% CI 0.31–0.95, respectively). Spearman’s correlations showed that relative abundance of B. pseudolongum was significantly correlated with ɑ-diversity (P < 0.01).ConclusionPreventive and treatment methods implying early gut microbiome intervention could be promising for the management of neonatal jaundice.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Meconium microbiome associates with the development of neonatal jaundice

Dong

Chen

White

et al. 2018

Clinical and Translational Gastroenterology

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“…There are two widely accepted methods of neonatal jaundice treatment, phototherapy and blood exchange (Amiri et al, 2014 ; Chen et al, 2017 ). In addition, herbal remedies are also very popular in the treatment of jaundice, especially in the Iranian tradition (Rajaei and Mohamadi, 2012 ; Amiri et al, 2014 ).…”

Section: Ethnopharmacological Approaches For Management Of Jaundice: mentioning

confidence: 99%

Ethnopharmacological Approaches for Therapy of Jaundice: Part I

et al. 2017

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Jaundice is a very common symptom especially in the developing countries. It is associated with several hepatic diseases which are still major causes of death. There are many different approaches to jaundice treatment and the growing number of ethnomedicinal studies shows the plant pharmacology as very promising direction. Many medicinal plants are used for the treatment of jaundice, however a comprehensive review on this subject has not been published. The use of medicinal plants in drug discovery is highly emphasized (based on their traditional and safe uses in different folk medicine systems from ancient times). Many sophisticated analytical techniques are emerging in the pharmaceutical field to validate and discover new biologically active chemical entities derived from plants. Here, we aim to classify and categorize medicinal plants relevant for the treatment of jaundice according to their origin, geographical location, and usage. Our search included various databases like Pubmed, ScienceDirect, Google Scholar. Keywords and phrases used for these searches included: “jaundice,” “hyperbilirubinemia,” “serum glutamate,” “bilirubin,” “Ayurveda.” The first part of the review focuses on the variety of medicinal plant used for the treatment of jaundice (a total of 207 medicinal plants). In the second part, possible mechanisms of action of biologically active secondary metabolites of plants from five families for jaundice treatment are discussed.

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“…Neonatal jaundice, presenting as yellow discoloration of the skin, sclera, and mucous membranes in infants and indicating raised serum bilirubin level, is one of the most common clinical conditions that may need medical attention (1). Unconjugated hyperbilirubinemia is the most common form of hyperbilirubinemia observed in neonates (2). Neonatal jaundice generally appears around two to four days after birth and vanishes one to two weeks later, often without the need for treatment.…”

Section: Introductionmentioning

confidence: 99%

“…Cumulatively, 24 million newborns develop jaundice every year (4). Approximately, 80% of preterm and 60% of term infants develop jaundice in the first week of life (2).…”

Section: Introductionmentioning

confidence: 99%

Detection of Neonatal Jaundice by Using an Android OS-Based Smartphone Application

Padidar¹,

Shaker²,

Amoozgar

et al. 2019

Iran J Pediatr

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Background: Neonatal jaundice resulting from raised blood bilirubin levels is one of the most common clinical conditions that needs medical attention. To initiate appropriate management that can both prevent and treat severe neonatal jaundice, screening methods that measure bilirubin level are warranted. Methods: In this study, we present an Android OS-based application for detecting neonatal jaundice. We used the application to detect jaundice in 113 neonates. Our smartphone-based estimation of bilirubin levels depends on a smartphone, a color calibration card, and a 100X zoom microscope clip. Our application was designed to acquire images of the newborn's forehead skin in a standardized manner, estimate the average R, G, B scores of the images that have been taken from the forehead skin and calibration card, and then convert them to hue, saturation, intensity (HSI) parameters. All these are performed offline; in this application, we used offline machine learning and regression techniques for analysis Results: Our smartphone-based estimation of bilirubin levels had a sensitivity of 68% and specificity of 92.3% for estimating the bilirubin levels of less than 10 mg/dL and sensitivity of 82.1% and specificity of 100% for estimating the bilirubin levels of less than 15 mg/dL. Our application-based estimation of bilirubin levels had the correlation of 0.479 with the total serum bilirubin values. Conclusions: Our results suggest that our smartphone-based application can serve as a promising screening tool for neonatal jaundice, and it can aid in determining neonates requiring a blood draw for measuring total serum bilirubin level.

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Probiotics Supplementation Therapy for Pathological Neonatal Jaundice: A Systematic Review and Meta-Analysis

Cited by 35 publications

References 18 publications

Meconium microbiome associates with the development of neonatal jaundice

Meconium microbiome associates with the development of neonatal jaundice

Ethnopharmacological Approaches for Therapy of Jaundice: Part I

Detection of Neonatal Jaundice by Using an Android OS-Based Smartphone Application

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