Probiotics and immune health

Abstract

Purpose of review The beneficial effects of probiotics have been demonstrated in many diseases. One of the major mechanisms of probiotic action is through the regulation of host immune response. This review highlights the recent scientific research findings that advance our understanding of probiotic regulation of the host immune response with potential application for disease prevention and treatment. Recent findings Probiotic genomic and proteomic studies have identified several genes and specific compounds derived from probiotics, which mediate immunoregulatory effects. Studies regarding the biological consequences of probiotics in host immunity suggested that they regulate the functions of systemic and mucosal immune cells and intestinal epithelial cells. Thus, probiotics showed therapeutic potential for diseases, including several immune response-related diseases, such as allergy, eczema, viral infection, and potentiating vaccination responses. Summary Probiotics may provide novel approaches for both disease prevention and treatment. However, the results of clinical studies regarding probiotic application are preliminary and require further confirmation.

The intestinal microbiome, probiotics and prebiotics in neurogastroenterology

“…The gut microbiota 6 and certain probiotics 7 can promote the development of the intestinal barrier. Some specific probiotic strains altered the expression of tight junction proteins including occludin, cingulin, claudin-2 and ZO-2.…”

A Lactobacillus rhamnosus GG-derived Soluble Protein, p40, Stimulates Ligand Release from Intestinal Epithelial Cells to Transactivate Epidermal Growth Factor Receptor

“…Probiotics are live microorganisms which, when consumed in adequate amounts as part of food, confer a health benefit on the host and may serve as a potential alternative therapy for disease prevention and treatment. Currently, both clinical and basic research has revealed several distinct cellular and molecular mechanisms underlying the beneficial effects of probiotics, including blocking pathogenic bacterial effects, regulating immune responses, and modulating intestinal epithelial homeostasis (3)(4)(5).…”

Intestinal Microbiota and Use of Probiotics in Pediatric Practice: News

“…В клинических и экспериментальных исследованиях показана эффективность пробиотиков при различных патологических состояниях, в том числе при диареях раз-личного генеза, проявлениях лактазной недостаточности у детей и взрослых, в послеоперационном периоде, при синдроме раздраженного кишечника и воспалительных заболеваниях кишечника [32][33][34]. …”