Probiotic Lactobacillus casei Shirota improves kidney function, inflammation and bowel movements in hospitalized patients with acute gastroenteritis – A prospective study

Akoglu, Bora; Loytved, Alexander; Nuiding, Hannah; Zeuzem, Stefan; Faust, Dominik

doi:10.1016/j.jff.2015.05.021

Cited by 19 publications

(7 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They contribute to improve food nutrition and ameliorate food flavor. At the same time, they have various probiotic functions such as the regulation of intestinal flora (Corinna et al, 2016) as well as the improvement of immunity (Akoglu et al, 2015). L. casei group, a type of lactic acid bacteria, can transit strong acid environments in the stomach and be colonized in the intestinal mucosa, thus play a major role in the prevention and treatment of gastrointestinal diseases.…”

Section: Introductionmentioning

confidence: 99%

Occurrence and Diversity of CRISPR Loci in Lactobacillus casei Group

Yang

Ujiroghene

et al. 2020

Front. Microbiol.

View full text Add to dashboard Cite

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) is an adaptive immune system that resists foreign genes through nuclease targeting in bacteria and archaea. In this study, we analyzed 68 strains of Lactobacillus casei group from the NCBI GenBank database, and bioinformatic tools were used to investigate the occurrence and diversity of CRISPR system. The results showed that a total of 30 CRISPR loci were identified from 27 strains. Apart from three strains which contained double loci with distinguishable distributed sites, most strains contained only one CRISPR locus. The analysis of direct repeat (DR) sequences showed that all DR could form stable RNA secondary structures. The CRISPR spacers showed diversity, and their origin and evolution were revealed through the investigation of their spacer sequences. In addition, a large number of CRISPR spacers showed perfect homologies to phage and plasmid sequences. Collectively, our results would contribute to researches of resistance in L. casei group, and also provide a new vision on the diversity and evolution of CRISPR/Cas system.

show abstract

Section: Introductionmentioning

confidence: 99%

Occurrence and Diversity of CRISPR Loci in Lactobacillus casei Group

Yang

Ujiroghene

et al. 2020

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

“…Moreover, many strains produce regulatory metabolites, such as short chain fatty acids, which strengthen the intestinal epithelium in order to maintain a healthy state. Lactic acid bacteria (LAB) such as Lactobacillus, Bifidobacterium, Streptococcus, and Enterococcus species are widely used as probiotics, as they were noted to have a clinical effect in reducing the symptoms of diarrhea, inflammatory bowel disease and irritable bowel syndrome 3 , 4 , 5 . To confer any health benefits, probiotics need to survive through the hostile environment of the digestion process in sufficient numbers (at least 10 6 colony forming units (CFU)), tolerating acids, bile, and pancreatic digestive enzymes, and finally adhere to the intestinal epithelium in the colon.…”

Section: Introductionmentioning

confidence: 99%

A human origin strain Lactobacillus acidophilus DDS-1 exhibits superior in vitro probiotic efficacy in comparison to plant or dairy origin probiotics

et al. 2018

View full text Add to dashboard Cite

Background: The health benefits of probiotics are well established and known to be strain-specific. However, the role of probiotics obtained from different origins and their efficacy largely remains unexplored. The aim of this study is to investigate the in vitro efficacy of probiotics from different origins.Methods: Probiotic strains utilized in this study include Lactobacillus acidophilus DDS-1 (human origin), Bifidobacterium animalis ssp. lactis UABla-12 (human origin), L. plantarum UALp-05 (plant origin) and Streptococcus thermophilus UASt-09 (dairy origin). Screening assays such as in vitro digestion simulation, adhesion, cell viability and cytokine release were used to evaluate the probiotic potential.Results: All strains showed good resistance in the digestion simulation process, especially DDS-1 and UALp-05, which survived up to a range of 107 to 108 CFU/mL from an initial concentration of 109 CFU/mL. Two human colonic mucus-secreting cells, HT-29 and LS174T, were used to assess the adhesion capacity, cytotoxicity/viability, and cytokine quantification. All strains exhibited good adhesion capacity. No significant cellular cytotoxicity or loss in cell viability was observed. DDS-1 and UALp-05 significantly upregulated anti-inflammatory IL-10 and downregulated pro-inflammatory TNF-α cytokine production. All the strains were able to downregulate IL-8 cytokine levels.Conclusion: Of the 4 strains tested, DDS-1 demonstrated superior survival rates, good adhesion capacity and strong immunomodulatory effect under different experimental conditions.

show abstract

“…This probiotic could decrease uremia toxin accumulation in the blood of ESRD patient (Ranganathan, 2013). Studies on probiotic supplement from Lactobacillus casei Shirota strain showed that there was a reduction of leukocyte and improvement in renal function as shown through increased GFR on gastroenteritis patients with acute kidney injury (Akoglu, 2015).…”

Section: Methodsmentioning

confidence: 99%

The Combination of Probiotic and Calcium Carbonate Decrease Monocyte Count of End-Stage Renal Disease Patient

Yulistianingsih¹,

Sulchan²,

Maryusman³

et al. 2018

Kemas

View full text Add to dashboard Cite

Elevated monocyte count is correlated to the decrease of renal function and disease progressivity on end-stage renal disease (ESRD) patients. Probiotic that utilize lactobacillus species is known to play a role in maintaining imunity system balance by inducing the monocyte apoptosis. The combination between probiotic and calcium carbonate could increase probiotic colonization in the gatrointestinal tract. The aim of this study was to analyze the effect of probiotic and calcium carbonate combination toward reduction of monocyte count on ESRD patient at Rumah Sehat Terpadu Dompet Dhuafa Bogor Hospital. This study was true experimental research with randomized pre-post test control group design. Twenty four ESRD patient were randomly enrolled into treatment group (n=12) and control (n=12). The treatment group received probiotic and calcium carbonate, whereas control group received standardized calcium carbonate for 21 days. There was a significant decrease of monocyte (p=0.03) after administration of probiotic and calcium carbonate.

show abstract

Probiotic Lactobacillus casei Shirota improves kidney function, inflammation and bowel movements in hospitalized patients with acute gastroenteritis – A prospective study

Cited by 19 publications

References 32 publications

Occurrence and Diversity of CRISPR Loci in Lactobacillus casei Group

Occurrence and Diversity of CRISPR Loci in Lactobacillus casei Group

A human origin strain Lactobacillus acidophilus DDS-1 exhibits superior in vitro probiotic efficacy in comparison to plant or dairy origin probiotics

The Combination of Probiotic and Calcium Carbonate Decrease Monocyte Count of End-Stage Renal Disease Patient

Contact Info

Product

Resources

About