Probiotic Effects of Feeding Heat-Killed Lactobacillus acidophilus and Lactobacillus casei to Candida albicans-Colonized Immunodeficient Mice

Wagner, R. Doug; Pierson, C; Warner, Thomas F.; Dohnalek, M; Hilty, Milo D.; Balish, Edward

doi:10.4315/0362-028x-63.5.638

Cited by 77 publications

(64 citation statements)

References 15 publications

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“…have been reported to improve growth performance of birds (Panda et al, 2006). There is also the implication that dead or inactive probiotic bacteria may improve performance and the health status of animals, possibly via similar mechanisms operating in animals fed viable probiotic bacteria (Wagner et al, 2000;Huang et al, 2004).…”

Section: Resultsmentioning

confidence: 99%

Effects of Dietary Supplementation of Fermented Rice Bran (FRB) or Fermented Broken Rice (FBR) on Laying Performance, Egg Quality, Blood Parameter, and Cholesterol in Egg Yolk of Hy-Line Brown Laying Hens

Kim¹,

박성복²,

Jeon³

et al. 2017

Korean J. Poult. Sci.

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This experiment was aimed at investigating the effects of dietary supplementation with fermented rice bran (FRB) or fermented broken rice (FBR) on egg-laying performance, egg quality, blood parameters, and cholesterol level in egg yolk of Hy-Line Brown egg-laying hens. Altogether, 144 Hy-Line Brown egg-laying hens (32-week-old) were randomly allocated to one of 4 dietary treatment groups, with 4 replicates per treatment. Of them, 3 treatments diets were prepared by supplementing the basal diet with 0.1% probiotics (PRO), 1% fermented rice bran (FRB), or 1% fermented broken rice (FBR) at the expense of corn. Hen-day egg production was higher (P<0.05) in PRO and FRB treatment groups than in the basal treatment groups. However, feed intake, egg weight, egg mass, and feed conversion ratio did not differ among the treatment groups. Additionally, supplementation with FRB or FBR did not affect eggshell strength, eggshell thickness, egg yolk color, and Haugh unit during the feeding trial. There was no significant difference in leukocyte count. Total cholesterol level was lower (P<0.05) in the FRB treatment group than in the basal treatment groups. Asparate aminotransferase, alanine transferase, glucose, and albumin levels were unaffected by dietary supplementation with FRB or FBR. Egg yolk cholesterol level was lower (P<0.05) in the FRB and FBR treatment groups than in the basal treatment groups. In conclusion, dietary supplementation with FRB or FBR improved egg-laying performance, and reduced the levels of total serum cholesterol and cholesterol in egg yolk of Hy-Line Brown egg-laying hens.(Key words: Hy-Line Brown laying hens, laying performance, fermented rice bran, fermented broken rice, total cholesterol) † To whom correspondence should be addressed : magic100@korea.kr

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Section: Resultsmentioning

confidence: 99%

Effects of Dietary Supplementation of Fermented Rice Bran (FRB) or Fermented Broken Rice (FBR) on Laying Performance, Egg Quality, Blood Parameter, and Cholesterol in Egg Yolk of Hy-Line Brown Laying Hens

Kim¹,

박성복²,

Jeon³

et al. 2017

Korean J. Poult. Sci.

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“…LAB are also known to inhibit C. albicans colonization of the epithelium of the gastrointestinal tract in mice and subsequent hyphal invasion and systemic infection (45)…”

Section: Resultsmentioning

confidence: 99%

“…In a mouse model of gastrointestinal candidiasis, prior inoculation with L. rhamnosus LGG reduced C. albicans levels and invasion (45). We tested whether L. rhamnosus LGG could inhibit C. albicans germ tube formation.…”

Section: L Rhamnosusmentioning

confidence: 99%

Regulation ofCandida albicansMorphogenesis by Fatty Acid Metabolites

2004

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Candida albicans is an opportunistic dimorphic fungus that inhabits various host mucosal sites. Conversion from the yeast to the hyphal form has been associated with increased virulence and mucosal invasiveness. C. albicans morphogenesis is regulated by multiple signals and signaling pathways. However, signals that control morphogenesis in vivo are unknown. We investigated the effects of host long chain fatty acids, eicosanoids, and bacterial short chain fatty acids on control of germination. None of the C 18 or C 20 fatty acids tested had an effect on enhancing germ tube formation (arachidonic acid, oleic acid, linolenic acid, or ␥-linolenic acid). Among the different eicosanoids, both prostaglandin E 2 and thromboxane B 2 significantly enhanced serum-induced germination by C. albicans. Addition of antiprostaglandin or antithromboxane antibodies to serum alone inhibited germ tube formation by almost 30%, while control antibody had no effect, indicating that these eicosanoids are major morphogenic factors in the serum. Since these molecules also bind to albumin, this may also explain the hyphal transforming activity in serum that associates with albumin. Interestingly, short chain fatty acids (butyric acid), the product of lactic acid bacteria (LAB), inhibited germination. In addition, LAB culture supernatants as well as live LAB also inhibited C. albicans morphogenesis. Overall, these results indicate that fatty acid metabolites and fatty acid pathways can up-regulate and down-regulate germination in C. albicans.

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“…Controlling fungal colonization, especially by opportunists, with the use of probiotic bacteria is appealing. One study showed the probiotic bacteria Lactobacillus acidophilus and Lactobacillus casei induce protection against systemic candidiasis in mice (Wagner et al 2000). Shortchain fatty acids (butyric acid) produced by lactic acid bacteria also inhibit filamentation and may prevent C. albicans from causing disease in the gut (Noverr and Huffnagle 2004a).…”

Section: Cross-kingdom Interactionsmentioning

confidence: 99%

The human gut mycobiome: pitfalls and potentials--a mycologists perspective

2015

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Abstract:We have entered the Age of the Microbiome, with new studies appearing constantly and whole journals devoted to the human microbiome. While bacteria outnumber other gut microbes by orders of magnitude, eukaryotes are consistently found in the human gut and are represented primarily by the fungi. Compiling 36 studies 1917-2015 we found at least 267 distinct fungal taxa have been reported from the human gut, and seemingly every new study includes one or more fungi not previously described from this niche. This diversity, while impressive, is illusory. If we examine gut fungi, we will quickly observe a division between a small number of commonly detected species (Candida yeasts, Saccharomyces and yeasts in the Dipodascaceae, and Malassezia species) and a long tail of taxa that have been reported only once. Furthermore, an investigation into the ecology of these rare species reveals that many of them are incapable of colonization or long-term persistence in the gut. This paper examines what we know and have yet to learn about the fungal component of the gut microbiome, or "mycobiome", and an overview of methods. We address the potential of the field while introducing some caveats and argue for the necessity of including mycologists in mycobiome studies.

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Probiotic Effects of Feeding Heat-Killed Lactobacillus acidophilus and Lactobacillus casei to Candida albicans-Colonized Immunodeficient Mice

Cited by 77 publications

References 15 publications

Effects of Dietary Supplementation of Fermented Rice Bran (FRB) or Fermented Broken Rice (FBR) on Laying Performance, Egg Quality, Blood Parameter, and Cholesterol in Egg Yolk of Hy-Line Brown Laying Hens

Effects of Dietary Supplementation of Fermented Rice Bran (FRB) or Fermented Broken Rice (FBR) on Laying Performance, Egg Quality, Blood Parameter, and Cholesterol in Egg Yolk of Hy-Line Brown Laying Hens

Regulation ofCandida albicansMorphogenesis by Fatty Acid Metabolites

The human gut mycobiome: pitfalls and potentials--a mycologists perspective

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