Regulation of<i>Candida albicans</i>Morphogenesis by Fatty Acid Metabolites

Noverr, Mairi C.; Huffnagle, Gary B.

doi:10.1128/iai.72.11.6206-6210.2004

Cited by 223 publications

(190 citation statements)

References 48 publications

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“…One study showed the probiotic bacteria Lactobacillus acidophilus and Lactobacillus casei induce protection against systemic candidiasis in mice (Wagner et al 2000). Shortchain fatty acids (butyric acid) produced by lactic acid bacteria also inhibit filamentation and may prevent C. albicans from causing disease in the gut (Noverr and Huffnagle 2004a).…”

Section: Cross-kingdom Interactionsmentioning

confidence: 99%

The human gut mycobiome: pitfalls and potentials--a mycologists perspective

2015

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Abstract:We have entered the Age of the Microbiome, with new studies appearing constantly and whole journals devoted to the human microbiome. While bacteria outnumber other gut microbes by orders of magnitude, eukaryotes are consistently found in the human gut and are represented primarily by the fungi. Compiling 36 studies 1917-2015 we found at least 267 distinct fungal taxa have been reported from the human gut, and seemingly every new study includes one or more fungi not previously described from this niche. This diversity, while impressive, is illusory. If we examine gut fungi, we will quickly observe a division between a small number of commonly detected species (Candida yeasts, Saccharomyces and yeasts in the Dipodascaceae, and Malassezia species) and a long tail of taxa that have been reported only once. Furthermore, an investigation into the ecology of these rare species reveals that many of them are incapable of colonization or long-term persistence in the gut. This paper examines what we know and have yet to learn about the fungal component of the gut microbiome, or "mycobiome", and an overview of methods. We address the potential of the field while introducing some caveats and argue for the necessity of including mycologists in mycobiome studies.

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Section: Cross-kingdom Interactionsmentioning

confidence: 99%

The human gut mycobiome: pitfalls and potentials--a mycologists perspective

2015

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“…The area occupied by hyphae and yeast cells (in mm) was determined for each image using the ImageJ program (version 1.32 for Windows), a public domain image processing program developed at the National Institutes of Health (NIH), Bethesda, USA. All areas of hyphae and yeast cells in each section were summed and the result was log 10 transformed.…”

Section: G Mellonella Histological Analysismentioning

confidence: 99%

“…All of these strains were able to inhibit the growth of C. albicans, but the inhibitory effects were dependent on the strain tested, dose administered and duration of treatment. [10][11][12] Therefore, further studies are needed to elucidate the inhibitory activity of Lactobacillus strains against C. albicans, particularly in terms of biofilm formation, filamentation capacity and infection potential.…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus acidophilus ATCC 4356 inhibits biofilm formation by C. albicans and attenuates the experimental candidiasis in Galleria mellonella

et al. 2015

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(2015) Lactobacillus acidophilus ATCC 4356 inhibits biofilm formation by C.albicans and attenuates the experimental candidiasis in Galleriamellonella, Virulence, 6:1, 29-39, DOI: 10.4161/21505594.2014 Probiotic strains of Lactobacillus have been studied for their inhibitory effects on Candida albicans. However, few studies have investigated the effect of these strains on biofilm formation, filamentation and C. albicans infection. The objective of this study was to evaluate the influence of Lactobacillus acidophilus ATCC 4356 on C. albicans ATCC 18804 using in vitro and in vivo models. In vitro analysis evaluated the effects of L. acidophilus on the biofilm formation and on the capacity of C. albicans filamentation. For in vivo study, Galleria mellonella was used as an infection model to evaluate the effects of L. acidophilus on candidiasis by survival analysis, quantification of C. albicans CFU/mL, and histological analysis. The direct effects of L. acidophilus cells on C. albicans, as well as the indirect effects using only a Lactobacillus culture filtrate, were evaluated in both tests. The in vitro results showed that both L. acidophilus cells and filtrate were able to inhibit C. albicans biofilm formation and filamentation. In the in vivo study, injection of L. acidophilus into G. mellonella larvae infected with C. albicans increased the survival of these animals. Furthermore, the number of C. albicans CFU/mL recovered from the larval hemolymph was lower in the group inoculated with L. acidophilus compared to the control group. In conclusion, L. acidophilus ATCC 4356 inhibited in vitro biofilm formation by C. albicans and protected G. mellonella against experimental candidiasis in vivo.

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“…and C. albicans have antagonistic relationship inside the gut. Even if not able to completely eradicate C. albicans, the bacterium could inhibit the growth and virulence of C. albicans by the production of hydrogen peroxide and organic acids [104,105]. Moreover, commensal Lactobacilli produce the metabolite indole-3-aldeyde (IAld) by tryptophan metabolism, activating the Ahr mediated IL-22 response which in turns reduces colonization by C. albicans [43].…”

Section: Fungi Inhabiting the Gutmentioning

confidence: 99%

Mycobiota: Micro-Eukaryotes Inhabiting Our Body as Commensals or Opportunistic Pathogens

Rizzetto¹,

Filippo²,

Cavalieri³

2015

Fungal Genom Biol

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The advent of metagenomics has profoundly revolutionized our way to describe microbial communities and discover sequence based biomarkers of health and disease. Similarly to bacteria commensal fungi are an essential part of human ecosystems being involved in the normal development of the immune system and for the maintenance of healthy tissues and physiological processes. More and more frequently patterns of fungal species are associated to immune disorders and increasing evidences are accumulating of the importance to study the co-occurrence of fungal flora and its microbial counterpart to understand the cross-talk between opportunistic fungi and the mammalian host. Here we critically analyze the studies investigating thefungal communities inhabiting ourbody, addressing at what extent the selection of the approaches and the molecular markers used determine the results obtained.

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Regulation ofCandida albicansMorphogenesis by Fatty Acid Metabolites

Cited by 223 publications

References 48 publications

The human gut mycobiome: pitfalls and potentials--a mycologists perspective

The human gut mycobiome: pitfalls and potentials--a mycologists perspective

Lactobacillus acidophilus ATCC 4356 inhibits biofilm formation by C. albicans and attenuates the experimental candidiasis in Galleria mellonella

Mycobiota: Micro-Eukaryotes Inhabiting Our Body as Commensals or Opportunistic Pathogens

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