Probiotic Bacteria for Healthier Aging: Immunomodulation and Metabolism of Phytoestrogens

Abstract

Age-related degeneration gives rise to a number of pathologies, many of them associated with imbalances of the microbiota and the gut-associated immune system. Thus, the intestine is considered a key target organ to improve the quality of life in senescence. Gut microbiota can have a powerful impact in the deterioration linked to aging by its nutritional and immunomodulatory activity. Reduced numbers of beneficial species and low microbial biodiversity in the elderly have been linked with pathogenesis of many diseases. A healthy lifestyle with an elderly customized diet including probiotics can contribute to reducing the chronic proinflammatory status and other age-related pathologies. Beneficial effects of probiotic lactic acid bacteria and bifidobacteria to alleviate some of these disorders based on their immunomodulatory properties as well as their capacity to produce bioactive metabolites from dietary phytoestrogens are summarized. On one hand, the preservation of gut barrier integrity and an increased ability to fight infections are the main reported immune benefits of probiotics. On the other hand, the intake of a diet rich in phytoestrogens along with the presence of selected probiotic bacteria may lead to the production of equol, enterolignans, and urolithins, which are considered protective against chronic diseases related to aging.

Lactobacillus plantarum KSFY06 on d‐galactose‐induced oxidation and aging in Kunming mice

“…They are widely used in the food industry and livestock and poultry, and have a great impact on people's daily life (Landete et al, 2017). They are widely used in the food industry and livestock and poultry, and have a great impact on people's daily life (Landete et al, 2017).…”

Lactobacillus paracasei ssp. paracasei YBJ01 reduced d-galactose–induced oxidation in male Kuming mice

“…Lactic acid bacteria are key to food manufacturing and maintaining human or animal health (Laiño et al, 2015;Landete et al, 2017), and LAB strains isolated from fermented foods may have antioxidant activity (Das and Goyal, 2015;Leite et al, 2015). Thus, we focused on studying antioxidant activity of LPSP-YBJ01 strain.…”

Lactobacillus and Bifidobacterium Improves Physiological Function and Cognitive Ability in Aged Mice by the Regulation of Gut Microbiota

“…Gut microbiota has become one of the hottest research topics in recent years, and age‐related degeneration gives rise to a number of pathologies with imbalances of the microbiota and the gut‐associated immune system . The gut barrier is the physical and functional separation between the environment and the host's interior and thereby plays an important role in regulating various physiological processes.…”