Pro198Leu Polymorphism in the Glutathione Peroxidase 1 Gene Contributes to Diabetic Peripheral Neuropathy in Type 2 Diabetes Patients

Buraczyńska, Monika; Buraczynska, Kinga; Drăgan, M; Książek, Andrzej

doi:10.1007/s12017-016-8438-2

Cited by 27 publications

(18 citation statements)

References 35 publications

(48 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some studies [62,63] underline the importance of maintaining an appropriate expression and activity of this selenoperoxidase to control redox balance and glucose and lipid metabolism. GPX1 polymorphism with risk of diabetes and obesity in different populations [64][65][66][67][68]. Oxidative stress-induced intestinal injury has been reduced by the addition of SOD, glutathione peroxidase, and N-acetylcysteine, which reduces intestinal tissue tumor necrosis factor-a concentrations with anti-inflammatory and antioxidant properties [69,70].…”

Section: Glutathione Peroxidasementioning

confidence: 99%

Glutathione Peroxidase in Health and Diseases

Sarıkaya¹,

Doğan²

2020

Glutathione System and Oxidative Stress in Health and Disease

View full text Add to dashboard Cite

The aim of this study is to give information to readers about the importance of glutathione peroxidase. The physiopathology of most diseases is not fully elucidated currently; however, in many epidemiological studies, there are limited studies indicating the relationship between low levels of glutathione peroxidase status and the rise of cancer risk in many types of cancer. Anytime, situations in case of the distortion due to imbalance between enzymatic and nonenzymatic antioxidants and oxidants which lost one of paired electrons in the atomic level mean reactive oxygen species (ROS) withal reactive nitrogen species (RNS) in favor of oxidants that are related to oxidative stress. The possible mechanisms of glutathione peroxidase have been reviewed using the major findings of more than 1000 papers related to the ROS, glutathione peroxidase, and oxidative stress. Oxidative stress plays an important role in the occurrence and development of most diseases in both animal and human studies. Moreover, antioxidants have protective effects against nearly 50 disease pathogenesis. Oxidative stress, which occurs as an outcome of lipid peroxidation, concurrently may have a key importance in the phase of carcinogenesis occurring with a multistage course devoted to environmental toxicity and in cancer pathogenesis.

show abstract

Section: Glutathione Peroxidasementioning

confidence: 99%

Glutathione Peroxidase in Health and Diseases

Sarıkaya¹,

Doğan²

2020

Glutathione System and Oxidative Stress in Health and Disease

View full text Add to dashboard Cite

show abstract

“…These results appeared to suggest that lower expression of Nrf2 would lead to reduced antioxidative function. This is particularly important from a DM perspective whereby ROS can be generated from the auto oxidation of glucose, activation of protein kinase C, methylglyoxal formation and glycosylation, hexosamine metabolism and the formation of sorbitol (Buraczynska et al 2017). A previous study has revealed that ROS accumulation is induced by Nrf2 inhibition (Yang et al 2018a).…”

Section: Discussionmentioning

confidence: 99%

miRNA-155 silencing reduces sciatic nerve injury in diabetic peripheral neuropathy

Chen

Liu

et al. 2019

Journal of Molecular Endocrinology

View full text Add to dashboard Cite

Neuropathic pain represents one of the most common complications associated with diabetes mellitus (DM) that impacts quality of life. Accumulating studies have highlighted the involvement of miRNAs in DM. Thus, the current study aimed to investigate the roles of miR-155 in diabetic peripheral neuropathy (DPN). In vitro DPN models were established using rat Schwann cells (SCs) by treatment with 5.5 mM glucose. Gain- or loss-of-function studies were conducted to determine the effect of miR-155 on Nrf2, cellular function, reactive oxygen species and inflammation. Rat DNP models were established by streptozotocin injection and damage of sciatic nerve. Next, miR-155 antagomir or agomir was employed to investigate the effects associated with miR-155 on motor and sciatic nerve conduction velocity (MNCV, SNCV), angiogenesis and inflammatory response in vivo. Nrf2 was identified to be a target of miR-155 by dual-luciferase reporter gene assay. Silencing of miR-155 or restoration of Nrf2 promoted cell proliferation, inhibited apoptosis and alleviated inflammation in vitro. miR-155 antagomir-induced inhibition increased MNCV and SNCV, strengthened angiogenesis and alleviated inflammation in DPN rats. Additionally, the effects exerted by miR-155 were reversed when Nrf2 was restored both in vitro and in vivo. Taken together, the key findings of our study provide evidence indicating that miR-155 targeted and suppressed Nrf2 in DPN. miR-155 silencing was found to alleviate sciatic nerve injury in DPN, highlighting its potential as a therapeutic target for DPN.

show abstract

“…ROS are targeted for removal by antioxidants and enzymes such as superoxide dismutases (SOD), catalase, glutathione peroxidases (GPx), peroxiredoxins, and thioredoxins. In preclinical diabetic rodent models and in diabetic patients, the expression of antioxidants such as GPx has been shown to be reduced resulting in increased markers of oxidative damage 14, 15, 16…”

Section: Reactive Oxygen Species and Oxidative Stressmentioning

confidence: 99%

Recent novel approaches to limit oxidative stress and inflammation in diabetic complications

et al. 2018

View full text Add to dashboard Cite

Diabetes is considered a major burden on the healthcare system of Western and non‐Western societies with the disease reaching epidemic proportions globally. Diabetic patients are highly susceptible to developing micro‐ and macrovascular complications, which contribute significantly to morbidity and mortality rates. Over the past decade, a plethora of research has demonstrated that oxidative stress and inflammation are intricately linked and significant drivers of these diabetic complications. Thus, the focus now has been towards specific mechanism‐based strategies that can target both oxidative stress and inflammatory pathways to improve the outcome of disease burden. This review will focus on the mechanisms that drive these diabetic complications and the feasibility of emerging new therapies to combat oxidative stress and inflammation in the diabetic milieu.

show abstract

Pro198Leu Polymorphism in the Glutathione Peroxidase 1 Gene Contributes to Diabetic Peripheral Neuropathy in Type 2 Diabetes Patients

Cited by 27 publications

References 35 publications

Glutathione Peroxidase in Health and Diseases

Glutathione Peroxidase in Health and Diseases

miRNA-155 silencing reduces sciatic nerve injury in diabetic peripheral neuropathy

Recent novel approaches to limit oxidative stress and inflammation in diabetic complications

Contact Info

Product

Resources

About