Pro-oxidant versus anti-oxidant effects of seeds aglycone extracts of Lepidium sativum and Eruca vesicaria Linn., in vitro, and on neutrophil nitro-oxidative functions

Tounsi, Nabila; Djerdjouri, Bahia; Yahia, Ouahiba Ait; Belkebir, Aicha

doi:10.1007/s13197-019-04021-z

Cited by 5 publications

(6 citation statements)

References 34 publications

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“…They concluded that methanol extracts of L. sativum seeds had the highest phenolic contents and antioxidant activity compared with ethanol or water extracts [ 41 ]. On the other hand, it was reported that the antioxidant and anti-inflammatory activities of L. sativum were dose-dependent [ 33 , 42 ].…”

Section: Resultsmentioning

confidence: 99%

“…It also increased glutathione and nitric oxide levels. They suggested that the flavonoids could act as an antioxidant to inhibit ROS production, scavenge and neutralize ROS and free radicals, preserve the levels of reduced GSH, and prevent oxidative damage of biomolecules [ 42 ]. Attia et al suggested that a methanol extract of L. sativum seeds could control diabetes, through an antioxidant effect and improving the lipid profile.…”

Section: Resultsmentioning

confidence: 99%

“…BioMed Research International ethanol or water extracts [41]. On the other hand, it was reported that the antioxidant and anti-inflammatory activities of L. sativum were dose-dependent [33,42].…”

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confidence: 99%

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Anti-inflammatory and Immunomodulatory Properties of Lepidium sativum

Vazifeh

Kananpour

Khalilpour

et al. 2022

BioMed Research International

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Background. Lepidium sativum (garden cress) is a member of the Brassicaceae family that has been utilized for medicinal and culinary purposes in centuries. Anti-inflammatory, antioxidant, immunomodulatory, hepatoprotective, antihypertensive, antiasthmatic, and hypoglycemic properties are found in various portions of the plant. The anti-inflammatory, antioxidant, and immunomodulatory effects of L. sativum were the subject of this review. Methods. The required information was gathered by searching the Web of Science, PubMed, and Scopus databases for the terms anti-inflammatory, antioxidant, immunomodulatory, immune system, and Lepidium sativum. Up until February 2022, the search was conducted. Results. TNF-, IL-6, IL-1, NO, iNOS, and HO-1 levels were reduced, indicating that L. sativum has anti-inflammatory and immunomodulatory properties. Flavonoids, alkaloids, cyanogenic glycosides, tannins, glucosinolates, sterols, and triterpenes are the key chemical components that contribute to the anti-inflammatory effects. In peritoneal neutrophils, L. sativum reduced oxidative stress by scavenging free radicals, as evidenced by a drop in superoxide anion and an increase in glutathione. Conclusion. The anti-inflammatory, antioxidant, and immunomodulatory activities of L. sativum could be explored in clinical trials to treat inflammatory and immune system illnesses.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Anti-inflammatory and Immunomodulatory Properties of Lepidium sativum

Vazifeh

Kananpour

Khalilpour

et al. 2022

BioMed Research International

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“…45 Determination of H + /K + -ATPase Activity in Gastric Tissue Microsomes. Gastric microsomes were isolated 46 after 1 h of incubation in 70 mM Tris-HCl buffer, pH 6.8, 5 mM MgCl 2 , and enzyme solution with 10 mM KCl. The reaction was initiated by adding 2 mM ATP Tris salt at 37 °C for 20 min and terminated with the addition of 10% trichloroacetic acid.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

Unique Novel Role of Adropin in a Gastric Ulcer in a Rotenone-Induced Rat Model of Parkinson’s Disease

Gheit

Atef

Deeb

et al. 2020

ACS Chem. Neurosci.

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Parkinson’s disease (PD) is the second most common neurodegenerative disease, frequently associated with a gastric ulcer. We aimed to investigate the adropin neuroprotective/gastroprotective potential in the indomethacin (IND)-induced gastric ulcer in a rotenone-induced PD model. Rats were randomly divided into four groups: normal control group, rotenone/IND treated (PD /Ulcer) group, adropin treated PD/Ulcer group, and l-dopa/omeprazole (Om) treated PD/Ulcer group. There were ten rats selected for the normal control group. Striatal dopamine (DA), apoptosis/redox status, and motor/behavioral impairments were evaluated. Gastric oxidative stress, H+/K+-ATPase activity, prostaglandin E2, mucin content, and von Willebrand factor were measured. Gastric/striatal phosphatidylinositol 3-kinase (PI3K)/phosphorylated Akt and gastric vascular endothelial growth factor (VEGF)/striatal P53 immunoreactivities were checked. Striatal P53 upregulated modulator of apoptosis (Puma)/gastric vascular endothelial growth factor receptor-2 (Vegfr-2) expressions were evaluated. Adropin successfully restored striatal DA and attenuated rotenone-induced motor/behavior deficits along with strong gastroprotective potential, possibly through antioxidant activity via reduction in malondialdehyde level and upregulated superoxide dismutase, catalase activities, and serum ferric reducing antioxidant power. Adropin restored the delicate balance between the defective pro-survival PI3K/Akt/murine double minute 2 signals and apoptotic P53/Puma pathways. Adropin can be considered as a uniquely attractive therapeutic target in PD and its associated gastric ulcer.

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“…and cress (Lepidium sativum L.) both cruciferous plants have rich sulforaphane ingredients that provide to induce NRF2-HO-1 antioxidant pathway (Bell et al 2015). In usual, it is beneficial to eat brassicaceous greens that reduce cancer, cardiovascular issues and diabetes (Podsędek 2007;Tounsi et al 2019).…”

Section: Introductionmentioning

confidence: 99%

Disodyum oktaborat tetrahidratın (DOT) Roka (Eruca sativa Mill.) ve Tere (Lepidium sativum L.)'de tohum çimlenmesi ve gelişimi üzerine etkileri

Erkan

Aşcı

2022

Bilge International Journal of Science and Technology Research

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Rocket (Eruca sativa Mill.) is cultivated throughout the year. Thanks to the rich metabolites of its leaves, it has a wide usage area in pharmacy. Cress (Lepidium sativum) is in the group of annual vegetables and has a herbaceous structure. Due to its fragrant and slightly spicy structure, it is a vegetable that is used as an appetizer. Its seeds and green parts are very beneficial for health. Rocket is a short-day plant whose leaves are considered to be rich in many minerals and vitamins. The present research was conducted to investigate the effects of doses of Disodium octaborate tetrahydrate (DOT) (0 (control), 15, 30, 45, 60 mg L -1 on the germination and development of seeds of rocket and cress plants grown in pot experiments. In order to determine the effect of DOT on the development and yield of rocket and cress plants, the percentage of germinated seeds, cotyledon length and dry matter amounts were determined. ANOVA test was used to analyze the data obtained in the present study. Tukey test was used to determine which groups were in significant differences between the groups. Overall, it was seen that there were significant growth differences between the doses used statistically, the particularly 45 mg L -1 application DOT positively affected the germination and dry matter content of rocket and cress seeds.

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Pro-oxidant versus anti-oxidant effects of seeds aglycone extracts of Lepidium sativum and Eruca vesicaria Linn., in vitro, and on neutrophil nitro-oxidative functions

Cited by 5 publications

References 34 publications

Anti-inflammatory and Immunomodulatory Properties of Lepidium sativum

Anti-inflammatory and Immunomodulatory Properties of Lepidium sativum

Unique Novel Role of Adropin in a Gastric Ulcer in a Rotenone-Induced Rat Model of Parkinson’s Disease

Disodyum oktaborat tetrahidratın (DOT) Roka (Eruca sativa Mill.) ve Tere (Lepidium sativum L.)'de tohum çimlenmesi ve gelişimi üzerine etkileri

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