Pristimerin inhibits angiogenesis in adjuvant-induced arthritic rats by suppressing VEGFR2 signaling pathways

Deng, Qiudi; Bai, Shutong; Gao, Wanjiao; Li, Tong

doi:10.1016/j.intimp.2015.11.001

Cited by 31 publications

(29 citation statements)

References 52 publications

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“…And considering the reports that Shh regulates the expression of many angiogenic growth factor, including VEGF, VEGFR2, Ang-1, Ang-2 and ENOS [22][23][24] , we speculate that pristrimerin may suppress the activation of Shh/Gli1 firstly and then its downstream VEGF/VEGR2 signaling pathway. And pristimerin-mediated anti-angiogenic effect may also partly depend on the activation of VEGF/ VEGR2 signaling pathway as previous study described 27 . Further study is needed to explore how Shh/Gli1 regulates VEGF/VEGFR2 signaling pathway.…”

Section: Discussionmentioning

confidence: 58%

“…Pristimerin also exhibits perfect anti-tumor effect in multiple types of cancers (colorectal cancer, breast cancer and prostate cancer) via inducing cell cycle arrest, apoptosis, necrosis and incomplete autophagy. Pristimerin also inhibits VEGF-induced endothelia cellular motilities and angiogenesis in adjuvant-induced arthritic rats by blocking VEGF/VEGFR2 signaling pathway 27,30 . However, its effect on tumor angiogenesis and Shh/Gli1 signaling pathway are still unclear.…”

Section: Introductionmentioning

confidence: 99%

“…Pristimerin, an active agent that isolated from traditional Chinese herbal medicine Celastrus aculeatus Merr, poses multiple pharmacological activities, such as antiinflammatory, antiperoxidative and antimicrobial [27][28][29] . Pristimerin also exhibits perfect anti-tumor effect in multiple types of cancers (colorectal cancer, breast cancer and prostate cancer) via inducing cell cycle arrest, apoptosis, necrosis and incomplete autophagy.…”

Section: Introductionmentioning

confidence: 99%

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Identification of a novel tumor angiogenesis inhibitor targeting Shh/Gli1 signaling pathway in Non-small cell lung cancer

et al. 2020

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Although angiogenesis inhibitors targeting VEGF/VEGFR2 have been applied for tumor therapy, the outcomes are still unsatisfactory. Thus, it is urgent to develop novel angiogenesis inhibitor for cancer therapy from new perspectives. Identification of novel angiogenesis inhibitor from natural products is believed to be one of most promising strategy. In this study, we showed that pristimerin, an active agent isolated from traditional Chinese herbal medicine Celastrus aculeatus Merr, was a novel tumor angiogenesis inhibitor that targeting sonic hedgehog (Shh)/glioma associated oncogene 1 (Gli1) signaling pathway in non-small cell lung cancer (NSCLC). We showed that pristimerin affected both the early-and late-stage of angiogenesis, suggesting by that pristimerin inhibited Shh-induced endothelial cells proliferation, migration, invasion as well as pericytes recruitment to the endothelial tubes, which is critical for the new blood vessel maturation. It also suppressed tube formation, vessel sprouts formation and neovascularization in chicken embryo chorioallantoic membrane (CAM). Moreover, it significantly decreased microvessel density (MVD) and pericyte coverage in NCI-H1299 xenografts, resulting in tumor growth inhibition. Further research revealed that pristimerin suppressed tumor angiogenesis by inhibiting the nucleus distribution of Gli1, leading to inactivation of Shh/Gli1 and its downstream signaling pathway. Taken together, our study showed that pristimerin was a promising novel antiangiogenic agent for the NSCLC therapy and targeting Shh/Gli1 signaling pathway was an effective approach to suppress tumor angiogenesis.

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Section: Discussionmentioning

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Identification of a novel tumor angiogenesis inhibitor targeting Shh/Gli1 signaling pathway in Non-small cell lung cancer

et al. 2020

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“…Vascular endothelial growth factor (VEGF) is involved in neovascularization in RA joints (Wang, Chen, et al, ). Triptolide; paeoniflorin; pristimerin; taxol; genistein; berberine; norisoboldine; 1,7‐dihydroxyl‐xanthone; 2‐hydroxyl‐1,7‐dimethoxylxanthone; 1,7‐dihydroxyl‐3,4‐dimethoxylxanthone; scopoletin; scopolin; and artemisinin inhibit angiogenesis in RA models by suppressing VEGF signaling pathway (Deng, Bai, Gao, & Tong, ; Hu, Liu, Liu, & Li, ; Lu et al, ; Pan et al, ; Pan, Gao, Li, Xia, & Dai, ; Wang, Chen, et al, ; Xu et al, ; Xu, Zhang, Zhang, & Ma, ; Yang, Hu, et al, ; Zhang, Shi, Tan, & Wang, ; Zheng et al, ; Zuo et al, ). In addition to VEGF, hypoxia‐inducible factor 1α may be also the target for the suppression of microvessel formation by taxol (Stoeltzing et al, ; Xu et al, ).…”

Section: The Anti‐ra Activities Of Chemical Constituents From Herbal mentioning

confidence: 99%

“…Scopoletin and scopolin significantly reduce the overexpression of fibroblast growth factor in synovial tissues of RA rats (Pan et al, ; Pan et al, ). Angiopoietin‐1 aggravates synovial angiogenesis through the activation of Tie2 signaling, which is also involved in the treatment of RA by pristimerin (Deng et al, ). MMP system activation is one of the necessary requirements for synovial matrix degradation, which is a crucial step in the initiation of new capillaries formation (Deng et al, ).…”

Section: The Anti‐ra Activities Of Chemical Constituents From Herbal mentioning

confidence: 99%

Herbal compounds for rheumatoid arthritis: Literatures review and cheminformatics prediction

Zhang

2019

Phytotherapy Research

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Rheumatoid arthritis (RA) is a systemic disease characterized by autoimmunity, joint inflammation, and cartilage destruction, which affects 0.5–1% of the population. Many compounds from herbal medicines show the potentials to treat RA. On this basis, the compounds with good pharmacokinetic behaviors and drug‐likeness properties will be further studied and developed. Therefore, the herbal compounds with anti‐RA activities were reviewed in this paper, and the cheminformatics tools were used to predict their drug‐likeness properties and pharmacokinetic parameters. A total of 90 herbal compounds were analyzed, which were reported to be effective on RA models through anti‐inflammation, chondroprotection, immunoregulation, antiangiogenesis, and antioxidation. Most of the herbal compounds have good drug‐likeness properties. Most of the compounds can be an alternative and valuable source for anti‐RA drug discovery.

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Mechanistic insights into anti‐inflammatory and immunosuppressive effects of plant secondary metabolites and their therapeutic potential for rheumatoid arthritis

Yuandani,

Jantan,

Salim

et al. 2024

Phytotherapy Research

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The anti‐inflammatory and immunosuppressive activities of plant secondary metabolites are due to their diverse mechanisms of action against multifarious molecular targets such as modulation of the complex immune system associated with rheumatoid arthritis (RA). This review discussed and critically analyzed the potent anti‐inflammatory and immunosuppressive effects of several phytochemicals and their underlying mechanisms in association with RA in experimental studies, including preliminary clinical studies of some of them. A wide range of phytochemicals including phenols, flavonoids, chalcones, xanthones, terpenoids, alkaloids, and glycosides have shown significant immunosuppressive and anti‐inflammatory activities in experimental RA models and a few have undergone clinical trials for their efficacy and safety in reducing RA symptoms and improve patient outcomes. These phytochemicals have potential as safer alternatives to the existing drugs in the management of RA, which possess a wide range of serious side effects. Sufficient preclinical studies on safety and efficacy of these phytochemicals must be performed prior to proper clinical studies. Further studies are needed to address the barriers that have so far limited their human use before the therapeutic potential of these plant‐based chemicals as anti‐arthritic agents in the treatment of RA is fully realized.

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Pristimerin inhibits angiogenesis in adjuvant-induced arthritic rats by suppressing VEGFR2 signaling pathways

Cited by 31 publications

References 52 publications

Identification of a novel tumor angiogenesis inhibitor targeting Shh/Gli1 signaling pathway in Non-small cell lung cancer

Identification of a novel tumor angiogenesis inhibitor targeting Shh/Gli1 signaling pathway in Non-small cell lung cancer

Herbal compounds for rheumatoid arthritis: Literatures review and cheminformatics prediction

Mechanistic insights into anti‐inflammatory and immunosuppressive effects of plant secondary metabolites and their therapeutic potential for rheumatoid arthritis

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