Herbal compounds for rheumatoid arthritis: Literatures review and cheminformatics prediction

Li, Xu‐zhao; Zhang, Shuai-nan

doi:10.1002/ptr.6509

Cited by 36 publications

(23 citation statements)

References 165 publications

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“…There is some common pathogenesis between OA and RA, such as inflammation, apoptosis, and oxidative stress, etc. [112]. Therefore, the potential of anti-RA drugs in the treatment of OA would be further explored in future researches.…”

Section: Discussionmentioning

confidence: 99%

“…The water solubility of the compounds can influence their efficacy in vivo. The good aqueous solubility can facilitate the molecules dispersing into biological body fluids, thereby expediting their absorption and distribution processes [112]. Water solubility assessment showed that most of herbal compounds (38/43) were soluble in water (> − 4 log mol/L), while five of 43 molecules were low soluble in water (< − 4 log mol/L, Table 2).…”

Section: Pharmacokinetic Parameters and Drug-likeness Properties Predmentioning

confidence: 99%

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Recent advance in treatment of osteoarthritis by bioactive components from herbal medicine

Zhang

2020

Chin Med

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Osteoarthritis (OA) is a common chronic articular degenerative disease, and characterized by articular cartilage degradation, synovial inflammation/immunity, and subchondral bone lesion, etc. The disease affects 2-6% of the population around the world, and its prevalence rises with age and exceeds 40% in people over 70. Recently, increasing interest has been devoted to the treatment or prevention of OA by herbal medicines. In this paper, the herbal compounds with anti-OA activities were reviewed, and the cheminformatics tools were used to predict their drug-likeness properties and pharmacokinetic parameters. A total of 43 herbal compounds were analyzed, which mainly target the damaged joints (e.g. cartilage, subchondral bone, and synovium, etc.) and circulatory system to improve the pathogenesis of OA. Through cheminformatics analysis, over half of these compounds have good drug-likeness properties, and the pharmacokinetic behavior of these components still needs to be further optimized, which is conducive to the enhancement in their drug-likeness properties. Most of the compounds can be an alternative and valuable source for anti-OA drug discovery, which may be worthy of further investigation and development.

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Section: Discussionmentioning

confidence: 99%

Section: Pharmacokinetic Parameters and Drug-likeness Properties Predmentioning

confidence: 99%

Recent advance in treatment of osteoarthritis by bioactive components from herbal medicine

Zhang

2020

Chin Med

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“…Modern pharmacological researches demonstrated that the effective active ingredients in Chinese medicine could weaken the activity of RA and protect joints from deformity [ 6 ]. In TCM theory, RA belongs to the category of therapeutic concept “Bi Zheng ”, which is related to the deficiency of vital qi as well as the invasion of “wind (feng)”, “cold (han)”, “damp (shi)”, “stasis (yu)” and other evil qi [ 7 , 8 ]. TCM can regulate the body function as a whole through a multifaceted approach and multiple mechanisms [ 9 ], therefore, it usually adopts the principles of warming the meridian, dispersing the cold and relieving the pain in RA treatment.…”

Section: Introductionmentioning

confidence: 99%

Use of Network Pharmacology to Investigate the Mechanism of the Compound Xuanju Capsule in the Treatment of Rheumatoid Arthritis

Wei¹,

Lu²,

Chen³

et al. 2021

BioMed Research International

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Objective. To clarify the therapeutic mechanisms of compound Xuanju capsule-treated rheumatoid arthritis (RA) based on network pharmacology tactics. Method. The TCMSP, TCMID and STITCH databases were used to screen the active ingredients and targets in the compound Xuanju capsule; the OMIM, TTD, PharmGKB and GeneCards databases were applied to screen the RA-related disease targets. Then, the obtained targets were imported into Cytoscape 3.7.1 software to construct the active ingredient-target network and the RA-related disease-target network. The active ingredient-target PPI network, the RA-related disease-target PPI network and the common target PPI network were built by using the STRING platform and Cytoscape 3.7.1 software. The GO and KEGG analyses of the common targets were analyzed by using the Metascape and Bioinformatics online tools. Results. A total of 51 active ingredients and 513 corresponding ingredient targets were harvested from the compound Xuanju capsule; 641 RA-related disease targets were obtained. After two PPI networks were constructed and merged, 116 RA-related targets of compound Xuanju capsules were identified and analyzed. 116 RA-related targets of compound Xuanju capsules are mainly involved in the biological processes and molecular functions, such as the cytokine-mediated signaling pathways, the response to lipopolysaccharide and the blood vascular development, the cytokine activity, the cytokine receptor binding and the receptor regulator activity. Furthermore, 116 RA-related targets of compound Xuanju capsules are concentrated in signaling pathways such as the IL-17, TNF, Th17 cell differentiation, Toll receptor and RA signaling pathway. Conclusion. The compound Xuanju capsule had the action characteristics of multiple components, multiple targets, and multiple pathways in the treatment of RA, which might primarily reduce the release of proinflammatory factors (such as IL-6 and TNF-α) and increase the production of anti-inflammatory factors (such as IL-10) by regulating inflammation-related signaling pathways (such as IL-17), thereby alleviating the inflammatory damage and improving the bone tissue repair.

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“…Currently available anti-rheumatic drugs, including non-steroidal drugs, glucocorticoids, and biological agents, cannot cure RA radically but only relieve its symptoms and progression [4,5]. In China, herbal medicines have been extensively utilized as alternative RA drugs for decades [6,7]. However, the traditional herbs contain a lot of ingredients which may result in serious side-effects [8].…”

Section: Introductionmentioning

confidence: 99%

Novel Carboxylated Chitosan-Based Triptolide Conjugate for the Treatment of Rheumatoid Arthritis

et al. 2020

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A new platform for triptolide (TP) delivery was prepared by conjugating TP to a carboxylmethyl chitosan (CMCS). Compared with the natural TP, the TP-conjugate (TP-CMCS) containing TP of ~5 wt% exhibited excellent aqueous solubility (>5 mg/mL). Results of in vitro experiments showed that TP-CMCS could relieve TP-induced inhibition on RAW264.7 cells and apoptosis, respectively. Compared with the TP group, TP-CMCS could effectively alleviate the toxicity injury of TP and decreased the mortality rate of the mice (p < 0.05). TP-CMCS did not cause much damage to the liver (AST and ALT) and kidney (BUN and CRE) (p < 0.05). After administration, the levels of IL-6, IL-1β, and TNF-α decreased, and the arthritis detumescence percentages increased significantly, and the bony erosion degree was distinctly decreased in the TP-CMCS groups and TP group. Our results suggested that TP-CMCS was a useful carrier for the treatment of RA, which enhanced aqueous solubility of free TP and reduced drug toxicity in vitro and in vivo.

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Herbal compounds for rheumatoid arthritis: Literatures review and cheminformatics prediction

Cited by 36 publications

References 165 publications

Recent advance in treatment of osteoarthritis by bioactive components from herbal medicine

Recent advance in treatment of osteoarthritis by bioactive components from herbal medicine

Use of Network Pharmacology to Investigate the Mechanism of the Compound Xuanju Capsule in the Treatment of Rheumatoid Arthritis

Novel Carboxylated Chitosan-Based Triptolide Conjugate for the Treatment of Rheumatoid Arthritis

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