Printing pharmaceuticals by inkjet technology: Proof of concept for stand-alone and continuous in-line printing on orodispersible films

Thabet, Yasmin; Šibanc, Rok; Breitkreutz, Jörg

doi:10.1016/j.jmapro.2018.07.018

Cited by 23 publications

(10 citation statements)

References 26 publications

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“…In the last decade, printing technologies have gained popularity in the pharmaceutical field. Inkjet printing, in particular, is a non-contact method for alternative manufacturing of orally delivered formulations [1]. Drop-on-demand thermal inkjet printing provides a number of advantages in pharmaceutical technology.…”

Section: Introductionmentioning

confidence: 99%

Development and Characterization of Inkjet Printed Edible Films for Buccal Delivery of B-Complex Vitamins

et al. 2020

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Buccal films containing two vitamins, i.e., thiamine hydrochloride (THCl) and nicotinic acid (NA), were fabricated via two-dimensional (2D) inkjet printing. For the preparation of buccal films, solubility studies and rheological evaluations were conducted in distilled water and propylene-glycol (PG) as main solvent and viscosity/surface tension modifier, respectively. The increased solubility in the solvents’ mixture indicated that manufacturing of several doses of the THCl and NA is achievable. Various doses were deposited onto sugar-sheet substrates, by increasing the number of printing passes. The physiochemical characterization (SEM, DSC, FTIR) revealed that inkjet printing does not affect the solid state of the matrix. Water uptake studies were conducted, to compare the different vitamin-loaded formulations. The in vitro release studies indicated the burst release of both vitamins within 10 min, a preferable feature for buccal administration. The in vitro permeation studies indicated that higher concentrations of the vitamins onto the sugar sheet improved the in vitro permeation performance of printed formulations.

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Section: Introductionmentioning

confidence: 99%

Development and Characterization of Inkjet Printed Edible Films for Buccal Delivery of B-Complex Vitamins

et al. 2020

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“…Inkjet printing is based on the deposition of the corrected dose of API on an edible substrate as solution or suspension. The substrate, which is generally made of water-soluble polymers (e.g., polysaccharides, cellulose derivatives), can be easily cut and handled by the patient [107,115].…”

Section: D Printingmentioning

confidence: 99%

Patient Centric Pharmaceutical Drug Product Design—The Impact on Medication Adherence

et al. 2020

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Medication adherence is a growing concern for public health and poor adherence to therapy has been associated with poor health outcomes and higher costs for patients. Interventions for improving adherence need to consider the characteristics of the individual therapeutic regimens according to the needs of the patients. In particular, geriatric and paediatric populations as well as dermatological patients have special needs/preferences that should be considered when designing drug products. Patient Centric Drug Product Pharmaceutical Design (PCDPD) offers the opportunity to meet the needs and preferences of patients. Packaging, orodispersible formulations, fixed dose combinations products, multiparticulate formulations, topical formulations and 3D printing are of particular relevance in a PCDPD process. These will be addressed in this review as well as their impact on medication adherence.

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“…It should be noted that printers do exist where a greater number of nozzles are available for use, illustrating potential for scaling up and speeding up the inkjet process.. For example, Kyobula et al, 2017 used a PIXDRO LP-50 printer where 128 nozzles were available (Kyobula et al, 2017). A proof-of-concept continuous printing system has also been developed for the inkjet printing of orodispersible films using PIXDRO JS 20 jetting station (128 nozzles) (Thabet et al, 2018).…”

Section: Printing Parametersmentioning

confidence: 99%

Water-based 3D inkjet printing of an oral pharmaceutical dosage form

Cader

Rance

Alexander

et al. 2019

International Journal of Pharmaceutics

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Inkjet printing is a form of additive manufacturing where liquid droplets are selectively deposited onto a substrate followed by solidification. The process provides significant potential advantages for producing solid oral dosage forms or tablets, including a reduction in the number of manufacturing steps as well as the ability to tailor a unique dosage regime to an individual patient. This study utilises solvent inkjet printing to print tablets through the use of a Fujifilm Dimatix printer. Using polyvinylpyrrolidone and thiamine hydrochloride (a model excipient and drug, respectively), a water-based ink formulation was developed to exhibit reliable and effective jetting properties. Tablets were printed on polyethylene terephthalate films where solvent evaporation in the ambient environment was the solidification mechanism. The tablets were shown to contain a drug loading commensurate with the composition of the 2 ink, in its preferred polymorphic phase of a non-stoichiometric hydrate distributed homogenously. The printed tablets displayed rapid drug release. This paper illustrates solvent inkjet printing's ability to print entire free-standing tablets without an edible substrate being part of the tablet and the use of additional printing methods. Common problems with solvent-based inkjet printing, such as the use toxic solvents, are avoided. The strategy developed here for tablet manufacturing from a suitable ink is general and provides a framework for the formulation for any drug that is soluble in water.

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Printing pharmaceuticals by inkjet technology: Proof of concept for stand-alone and continuous in-line printing on orodispersible films

Cited by 23 publications

References 26 publications

Development and Characterization of Inkjet Printed Edible Films for Buccal Delivery of B-Complex Vitamins

Development and Characterization of Inkjet Printed Edible Films for Buccal Delivery of B-Complex Vitamins

Patient Centric Pharmaceutical Drug Product Design—The Impact on Medication Adherence

Water-based 3D inkjet printing of an oral pharmaceutical dosage form

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