Printable Heterostructured Bioelectronic Interfaces with Enhanced Electrode Reaction Kinetics by Intermicroparticle Network

Abstract

Printable organic bioelectronics provide a fast and cost-effective approach for the fabrication of novel biodevices, while the general challenge is to achieve optimized reaction kinetics at multiphase boundaries between biomolecules and electrodes. Here, we present an entirely new concept based on a modular approach for the construction of heterostructured bioelectronic interfaces by using tailored functional "biological microparticles" combined with "transducer microparticles" as modular building blocks. This approach offers high versatility for the design and fabrication of bioelectrodes with a variety of forms of interparticle spatial organization, from layered-structures to more advance bulk heterostructured architectures. The heterostructured biocatalytic electrodes delivered twice the reaction rate and a six-fold increase in the effective diffusion kinetics in response to a catalytic model using glucose as the substrate, together with the advantage of shortened diffusion paths for reactants between multiple interparticle junctions and large active particle surface. The consequent benefits of this improved performance combined with the simple means of mass production are of major significance for the emerging printed electronics industry.

Modulating Electrode Kinetics for Discrimination of Dopamine by a PEDOT:COOH Interface Doped with Negatively Charged Tricarboxylate

“…The employment of PEDOT in organic electronics is attractive due to its reversible doping state, good electronic and ionic conductivity, excellent stability, and interesting optical and electrochemical properties. In addition to organic electronics, PEDOT has also been widely applied in biointerfaces and biomaterials for biomedical applications in recent years. , Further fine-tailoring of the conducting polymer interfaces to improve the conductivity, functionality, morphology and compatibility is required to meet the demands of specific applications such as target recognition, , cell capture, , chronic neural interfaces, and enhanced electrochemical performacne. − …”