Modulating Electrode Kinetics for Discrimination of Dopamine by a PEDOT:COOH Interface Doped with Negatively Charged Tricarboxylate

Meng, Lingyin; Turner, Anthony P. F.; Mak, Wing Cheung

doi:10.1021/acsami.9b12946

Cited by 35 publications

(30 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The existence of bands at 1750 and 1680 cm -1 related to -C=O for PEDOT-COOH25%100%, implies the successful co-polymerisation of EDOT-COOH into the Nano-PEDOT-COOH matrix. The total surface density of carboxylic acid groups on the Nano-PEDOT-COOH surfaces was quantified by the TBO staining technique as previously reported (Meng et al 2019a;Rödiger et al 2011). Figure 1d displays the linear increase of carboxylic acid group density from 0.03 µmol cm -2 for PEDOT-COOH25% to 0.18 µmol cm -2 for PEDOT-COOH100%.…”

Section: Resultsmentioning

confidence: 80%

“…Fourier transform infrared (FTIR) spectroscopy was performed using a VERTEX spectrometer (Bruker, USA) equipped with an attenuated total reflection (ATR) measuring cell. The density of carboxylic acid groups on different Nano-PEDOT-COOH biointerfaces were examined via toluidine blue O (TBO) staining assay (Meng et al 2019a). In brief, PEDOT-COOH electrodes (0.6 cm 2 ) were incubated in 2 mM TBO solution (0.1 mM KOH) for 2 h. Under alkaline conditions, the carboxylic acid groups deprotonate to bind with the positively charged TBO molecules with a ratio of 1:1.…”

Section: Characterisations and Electrochemical Measurementsmentioning

confidence: 99%

“…Carboxylic acid containing molecules, such as citrate (Meng et al 2019a) and hyaluronic acid (Mantione et al 2016) can be incorporated into the CP matrix as a dopant to compensate for the backbone charge, thus endowing the resulting CP interface with a high -COOH density.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Tunable 3D nanofibrous and bio-functionalised PEDOT network explored as a conducting polymer-based biosensor

Meng

Turner

Mak

2020

Biosensors and Bioelectronics

Self Cite

View full text Add to dashboard Cite

Conducting polymers that possess good electrochemical properties, nanostructured morphology and functionality for bioconjugation are essential to realise the concept of all-polymer-based biosensors that do not depend on traditional nanocatalysts such as carbon materials, metal, metal oxides or dyes. In this research, we demonstrated a facile approach for the simultaneous preparation of a bi-functional PEDOT interface with a tunable 3D nanofibrous network and carboxylic acid groups (i.e. Nano-PEDOT-COOH) via controlled co-polymerisation of EDOT and EDOT-COOH monomers, using tetrabutylammonium perchlorate as a soft-template. By tuning the ratio between EDOT and EDOT-COOH monomer, the nanofibrous structure and carboxylic acid functionalisation of Nano-PEDOT-COOH were varied over a fibre diameter range of 15.6 ± 3.7 to 70.0 ± 9.5 nm and a carboxylic acid group density from 0.03 to 0.18 µmol cm -2 . The nanofibres assembled into a three-dimensional network with a high specific surface area, which contributed to low charge transfer resistance and high transduction activity towards the co-enzyme NADH, delivering a wide linear range of 20960 M and a high sensitivity of 0.224 A M -1 cm -2 at the Nano-PEDOT-COOH50% interface. Furthermore, the carboxylic acid groups provide an anchoring site for the stable immobilisation of an NADH-dependent dehydrogenase (i.e. lactate dehydrogenase), via EDC/S-NHS chemistry, for the fabrication of a Bio-Nano-PEDOT-based biosensor for lactate detection which had a response time of less than 10 s over the range of 0.051.8 mM. Our developed bio-Nano-PEDOT interface shows future

show abstract

Section: Resultsmentioning

confidence: 80%

Section: Characterisations and Electrochemical Measurementsmentioning

confidence: 99%

See 1 more Smart Citation

Tunable 3D nanofibrous and bio-functionalised PEDOT network explored as a conducting polymer-based biosensor

Meng

Turner

Mak

2020

Biosensors and Bioelectronics

Self Cite

View full text Add to dashboard Cite

show abstract

“…The high-resolution SEM confirmed that MOF525 was attached to the surface of PEpC ( Figure 8 b). The CV diagrams showed that the PEpC modified microelectrode was also catalytically active for DA ( Figure 8 c), where the catalytic capability may be ascribed to the carboxylic group [ 51 ]. The MOF525/PEpC modified microelectrode exhibited a more distinct oxidation peak, and the S/B ratio reached 1.74.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of MOF525/PEDOT Composites as Microelectrodes for Electrochemical Sensing of Dopamine

et al. 2020

View full text Add to dashboard Cite

Dopamine (DA) is an important neurotransmitter responsible for the functions and activities of multiple systems in human. Electrochemical detection of DA has the advantages of fast analysis and cost-effectiveness, while a regular electrode probe is restricted to laboratory use because the probe size is too large to be suitable for an in vivo or in vitro analysis. In this study, we have developed porphyrin-based metal organic framework (MOF525) and poly(3,4-ethylenedioxythiophene) (PEDOT)-based composites to modify microelectrode for DA detection. Two types of PEDOT monomers with different functional groups were investigated in this study. By varying the monomer ratios, electrolyte concentrations, and electropolymerization temperature, it was found that the PEDOT monomer containing carboxylic group facilitated the formation of regular morphology during the electropolymerization process. The uniform morphology of the PEDOT promoted the electron transmission efficiency in the same direction, while the MOF525 provided a large reactive surface area for electrocatalysis of DA. Thus, the MOF525/PEDOT composite improved the sensitivity-to-noise ratio of DA signaling, where the sensitivity reached 11 nA/μM in a good linear range of 4–100 µM. In addition, porphyrin-based MOF could also increase the selectivity to DA against other common clinical interferences, such as ascorbic acid and uric acid. The as-synthesized microelectrode modified with MOF525/PEDOT in this study exhibited great potential in real time analysis.

show abstract

“…In addition, the initial spike of current corresponding to the charging of the double layer at S-RGO was 243 mA, which is much larger than those of GO (73 mA) and RGO (39 mA). Moreover, the interfacial capacitance 41 of the resulted PEDOT:S-RGO ( Fig. S5, ESI †) was estimated to be 14.4 mF cm À2 , which is 2.8 and 7.8 times higher than that of PEDOT:RGO (5.1 mF cm À2 ) and PEDOT:GO (1.8 mF cm À2 ), respectively.…”

Section: Efficient Electropolymerisation Of Pedot Doped With S-rgo (Pmentioning

confidence: 98%

Bi-functional sulphonate-coupled reduced graphene oxide as an efficient dopant for a conducting polymer with enhanced electrochemical performance

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

Modulating Electrode Kinetics for Discrimination of Dopamine by a PEDOT:COOH Interface Doped with Negatively Charged Tricarboxylate

Cited by 35 publications

References 52 publications

Tunable 3D nanofibrous and bio-functionalised PEDOT network explored as a conducting polymer-based biosensor

Tunable 3D nanofibrous and bio-functionalised PEDOT network explored as a conducting polymer-based biosensor

Synthesis of MOF525/PEDOT Composites as Microelectrodes for Electrochemical Sensing of Dopamine

Bi-functional sulphonate-coupled reduced graphene oxide as an efficient dopant for a conducting polymer with enhanced electrochemical performance

Contact Info

Product

Resources

About