Principles and Characteristics of Polymerization-Induced Self-Assembly with Various Polymerization Techniques

Cornel, Erik Jan; Jiang, Jinhui; Chen, Shuai; Du, Jianzhong

doi:10.31635/ccschem.020.202000470

Cited by 102 publications

(92 citation statements)

References 163 publications

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“…Polymer vesicles and micelles are generally self-assembled from amphiphilic block copolymers [97][98][99]. Polymer vesicles are hollow nanometer-sized spheres with a bilayer or interdigitated membrane and hydrophilic coronas [100][101][102], whereas polymer micelles consist of a solid core instead of a lumen.…”

Section: Polymeric Vesicles/micellesmentioning

confidence: 99%

Ultrasound-responsive polymer-based drug delivery systems

Wei

Cornel

2021

Drug Deliv. and Transl. Res.

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Ultrasound-responsive polymeric materials have received a tremendous amount of attention from scientists for several decades. Compared to other stimuli-responsive materials (such as UV-, thermal-, and pH-responsive materials), these smart materials are more applicable since they allow more efficient drug delivery and targeted treatment by fairly non-invasive means. This review describes the recent advances of such ultrasound-responsive polymer-based drug delivery systems and illustrates various applications. More specifically, the mechanism of ultrasound-induced drug delivery, typical formulations, and biomedical applications (tumor therapy, disruption of blood-brain barrier, fighting infectious diseases, transdermal drug delivery, and enhanced thrombolysis) are summarized. Finally, a perspective on the future research directions for the development of ultrasound-responsive polymeric materials to facilitate a clinical translation is given.

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Section: Polymeric Vesicles/micellesmentioning

confidence: 99%

Ultrasound-responsive polymer-based drug delivery systems

Wei

Cornel

2021

Drug Deliv. and Transl. Res.

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“…One strategy is ring-opening polymerization of N-carboxyanhydride-induced self-assembly (NCA-PISA). [148,149] NCA-PISA enables selfassembly of polypeptides into nanostructures at high concentrations simultaneously with the chain growth, which is facile and efficient for the amplified preparation of polypeptide nanomaterials. With contrast agents modified α-amino acid NCA, it would be possible to prepare polypeptide-based imaging platforms at a large scale through NCA-PISA.…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Advances and Perspectives of Peptide and Polypeptide‐Based Materials for Biomedical Imaging

Cornel

Fan

et al. 2021

Advanced NanoBiomed Research

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Biomedical imaging is an effective tool to reveal internal structures beneath the skin. Such tools are of great importance for disease diagnosis and treatment. Various small molecules, polymers, and micro‐ or nanomaterials have been applied as imaging agents for contrast enhancement. Peptide‐ and polypeptide‐based materials have been designed and developed for enhanced and multifunctional imaging, due to their excellent biocompatibility and diverse biofunctionality. This review aims to summarize recent advances in peptide‐ and polypeptide‐based materials for X‐ray computed tomography (CT), magnetic resonance imaging (MRI), fluorescence imaging (FLI), positron emission tomography (PET), single‐photon emission computed tomography (SPECT), and multimodal imaging. In addition to biomedical imaging, peptide‐ and polypeptide‐based materials have also been endowed with therapeutic functions for disease theranostics. This review is concluded with a perspective on future peptide‐ and polypeptide‐based materials for biomedical imaging.

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“…With the rapid development of nanotechnology and biotechnology ( Jiang et al, 2020 ; Cornel et al, 2021 ), the combination of thrombolytic therapy and nanocarriers may provide a novel solution to key issues, such as the short half-life, low targeting ability, and unexpected bleeding complications of the existing therapeutic drugs ( Zamanlu et al, 2018 ; Ma et al, 2019 ; Hassanpour et al, 2020 ). Polymeric nanocarriers based on macromolecules can provide the protection and targeted delivery of thrombolytic drugs through the unique physicochemical property brought by the nanoscale and the facile design of polymer chains.…”

Section: Introductionmentioning

confidence: 99%

Thrombus-Targeting Polymeric Nanocarriers and Their Biomedical Applications in Thrombolytic Therapy

Guan

Dou

2021

Front. Physiol.

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Due to the high morbidity and mortality of cardiovascular diseases, there is an urgent need for research on antithrombotic strategies. In view of the short half-life, insufficient drug penetration, poor targeting capabilities, and hemorrhagic side-effects of traditional thrombus treatment methods, the combination of thrombolytic therapy and nanocarriers brought by the development of nanotechnology in recent years may provide effective solutions for these undesirable side-effects caused by insufficient targeting. Polymeric nanocarriers, based on macromolecules and various functional groups, can connect specific targeting molecules together through chemical modification to achieve the protection and targeted delivery of thrombolytic drugs. However, simple chemical molecular modifications may be easily affected by the physiological environment encountered in the circulatory system. Therefore, the modification of nanocarriers with cell membranes can provide camouflage to these platforms and help to extend their circulation time while also imparting them with the biological functions of cell membranes, thus providing them with precise targeting capabilities, among which the most important is the biological modification of platelet membranes. In addition, some nanoparticles with their own therapeutic functions have also been developed, such as polypyrrole, which can exhibit a photothermal effect to induce thrombolysis. Herein, combined with the mechanism of thrombosis and thrombolysis, we outline the recent advances achieved with thrombus-targeting nanocarriers with regard to thrombosis treatment. On this basis, the design considerations, advantages, and challenges of these thrombolytic therapies in clinical transformation are discussed.

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Principles and Characteristics of Polymerization-Induced Self-Assembly with Various Polymerization Techniques

Abstract: Citation denotes calendar and volume year of first online publication.

Cited by 102 publications

References 163 publications

Ultrasound-responsive polymer-based drug delivery systems

Ultrasound-responsive polymer-based drug delivery systems

Advances and Perspectives of Peptide and Polypeptide‐Based Materials for Biomedical Imaging

Thrombus-Targeting Polymeric Nanocarriers and Their Biomedical Applications in Thrombolytic Therapy

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