Advances and Perspectives of Peptide and Polypeptide‐Based Materials for Biomedical Imaging

Lv, Mingchen; Cornel, Erik Jan; Fan, Zhen; Du, Jianzhong

doi:10.1002/anbr.202000109

Cited by 7 publications

(3 citation statements)

References 147 publications

(226 reference statements)

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“…Polypeptide-based nanomaterials have attracted a great deal of attention in many research fields owing to their inherent biocompatibility, biodegradability, versatile side-chain designs, and diverse biological functionalities. [1][2][3][4][5] A variety of welldefined nanostructures, such as spherical micelles, vesicles, and nanofibers, can be conveniently obtained from aqueous solutions, making them superior candidates for biomedical applications. [6][7][8][9][10][11] Recently, polypeptide-based nanogels have emerged as promising nano-scaffolds.…”

Section: Introductionmentioning

confidence: 99%

One-pot preparation of polypeptide nanogels in aqueous solutionviaring-opening polymerization-induced nano-gelation

et al. 2023

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Section: Introductionmentioning

confidence: 99%

One-pot preparation of polypeptide nanogels in aqueous solutionviaring-opening polymerization-induced nano-gelation

et al. 2023

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“…Over the past few years, peptides have gained ground in biomedical imaging, 1 developing new sensing platforms 2 and targeting treatments. 3 This tremendous interest arises from their physicochemical and biological properties.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Peptides for Molecular Recognition of C-Reactive Protein–Theoretical and Experimental Studies

Szot-Karpińska,

Kudła,

Orzeł

et al. 2023

Anal. Chem.

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We investigate the interactions between C-reactive protein (CRP) and new CRP-binding peptide materials using experimental (biological and physicochemical) methods with the support of theoretical simulations (computational modeling analysis). Three specific CRP-binding peptides (P2, P3, and P9) derived from an M13 bacteriophage have been identified using phage-display technology. The binding efficiency of the peptides exposed on phages toward the CRP protein was demonstrated via biological methods. Fibers of the selected phages/peptides interact differently due to different compositions of amino acid sequences on the exposed peptides, which was confirmed by transmission electron microscopy. Numerical and experimental studies consistently showed that the P3 peptide is the best CRP binder. A combination of theoretical and experimental methods demonstrates that identifying the best binder can be performed simply, cheaply, and fast. Such an approach has not been reported previously for peptide screening and demonstrates a new trend in science where calculations can replace or support laborious experimental techniques. Finally, the best CRP binderthe P3 peptidewas used for CRP recognition on silicate-modified indium tin oxide-coated glass electrodes. The obtained electrodes exhibit a wide range of operation (1.0–100 μg mL–1) with a detection limit (LOD = 3σ/S) of 0.34 μg mL–1. Moreover, the dissociation constant K d of 4.2 ± 0.144 μg mL–1 (35 ± 1.2 nM) was evaluated from the change in the current. The selectivity of the obtained electrode was demonstrated in the presence of three interfering proteins. These results prove that the presented P3 peptide is a potential candidate as a receptor for CRP, which can replace specific antibodies.

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“…This work mainly focuses on the recent work for cancer therapy, for peptide and polypeptide based biomaterials for biomedical imaging, the readers are encouraged to read the very recent excellent review. [ 28 ] We start with a less‐discussed aspect of different triggers to induce peptide assemblies. Then we introduce the recent progresses of in situ construction of assemblies for biomedical applications with emphasis on cancer therapy.…”

Section: Introductionmentioning

confidence: 99%

In Situ Construction of Functional Assemblies in Living Cells for Cancer Therapy

Yang

Cao

et al. 2021

Adv Healthcare Materials

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Peptide-based materials hold great promise for various biomedical applications and have drawn increasing attention over the past five years. Despite the progress in fabrication and handling peptide materials in vitro, manipulating assemblies of peptides in living cells (or animals) is still in its infancy. In this contributing review, recent work is summarized using endogenous triggers to construct functional assemblies of peptides in vivo. After introducing the triggers for inducing peptide assemblies, the recent progress is highlighted of the in situ construction of assemblies for biomedical applications with emphasis on cancer therapy. Finally, a brief perspective is provided to discuss the future promises and challenges of this emerging area of supramolecular chemistry.

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Advances and Perspectives of Peptide and Polypeptide‐Based Materials for Biomedical Imaging

Cited by 7 publications

References 147 publications

One-pot preparation of polypeptide nanogels in aqueous solutionviaring-opening polymerization-induced nano-gelation

One-pot preparation of polypeptide nanogels in aqueous solutionviaring-opening polymerization-induced nano-gelation

Investigation of Peptides for Molecular Recognition of C-Reactive Protein–Theoretical and Experimental Studies

In Situ Construction of Functional Assemblies in Living Cells for Cancer Therapy

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