Primordial Germ Cell Proliferation in Fetal Testes in Mouse Strains With High and Low Incidences of Congenital Testicular Teratomas

Noguchi, Takehiko; Stevens, Leroy C.

doi:10.1016/s0022-5347(17)52692-0

Cited by 26 publications

(43 citation statements)

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“…This work resulted in the identification of the ter mutant which exhibits loss of PGCs in a range of inbred and outbred mouse strains and PGC loss combined with strong susceptibility to teratoma in the 129sv strain (Stevens, 1973). EC cells, derived from transformed germ cells, have been observed in 129sv or in 129 ter mice as early as E15 or E16 respectively (Noguchi and Stevens, 1982;Rivers and Hamilton, 1986) indicating that teratoma in these mice arise from very early male germ cells.…”

Section: Germ Cell Cancermentioning

confidence: 99%

“…It has been observed that in 129 ter mice, teratoma foci can occur in the testis cords of E15.5 mice (Noguchi and Stevens, 1982) and that the environment of the early differentiating testis influences the incidence of teratoma. When E12.5 genital ridges were transplanted to adult testes the incidence of teratoma was high, but this incidence became substantially and progressively lower when E13.5 and E14.5 genital ridges were transplanted the same way (Stevens, 1964;Stevens, 1966).…”

Section: Germ Cell Cancermentioning

confidence: 99%

“…Interestingly, in mice of the 129sv strain it was shown that male germ cell proliferation was maintained longer and the incidence of teratomas increased in some lines (Noguchi and Stevens, 1982). Thus it appears that differentiation down the spermatogenic pathway and cell cycle exit reduce the potential of germ cells to establish teratoma.…”

Section: Germ Cell Cancermentioning

confidence: 99%

See 2 more Smart Citations

Foetal germ cells: striking the balance between pluripotency and differentiation

Western¹

2009

Int. J. Dev. Biol.

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Section: Germ Cell Cancermentioning

confidence: 99%

Section: Germ Cell Cancermentioning

confidence: 99%

Section: Germ Cell Cancermentioning

confidence: 99%

See 1 more Smart Citation

Foetal germ cells: striking the balance between pluripotency and differentiation

Western¹

2009

Int. J. Dev. Biol.

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“…The Ter mutation is a single base substitution in exon 3 of Dnd1 that transforms an arginine residue to a premature stop codon (p.Arg178X) (Youngren et al, 2005). In the 129 mouse, the Ter mutation (in DND1) has been characterized as a modifier gene for amplifying the incidence of spontaneous TGCTs (Asada et al, 1994;Noguchi and Stevens, 1982). The 129-Ter mouse is a model for prepubertal type I testicular germ cell tumors (Oosterhuis and Looijenga, 2005).…”

Section: Oncogenesismentioning

confidence: 99%

DND1 (DND microRNA-mediated repression inhibitor 1)

Matin¹

2018

Atlas of Genetics and Cytogenetics in Oncology and Haematology

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DND1 is a RNA binding protein. Initially identified in the zebrafish, where knockdown of dnd in the early embryo resulted in loss of primordial germ cells (Weidinger et al., 2003). Mutations in Dnd1 in mice and rats, thought to result in expression of a truncated DND1 protein, are oncogenic and result in germ cell depletion as well as germ cell tumors (Youngren et al., 2005;Northrup et al., 2012). DND1 is required for the survival of primordial germ cells during early development. Primordial germ cells are the stem cells from which germ cell tumors arise (Stevens, 1967). Total deficiency of DND1 in mice results in early embryonic lethality (Zechel et al., 2013). In humans, mutations and deregulation of DND1 expression have been reported in testicular cancer as well as other types of cancers (Bhandari et al., 2012;Linger et al., 2008;Sijmons et al., 2010). One function of DND1 is as a translational regulator (Kedde et al., 2007).

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“…Trying to go back to teratocarcinoma cellular roots, Stevens showed that this tumour can be induced experimentally by explanting gonadal ridges of foetuses, between 11.5 and 13.5 days post coitum of development, to ectopic sites (Stevens, 1967) and that teratoma formation occurs during fetal development in the highly susceptible 129/SvJ strain (Noguchi and Stevens, 1982, Stevens, 1967). Teratomas or teratocarcinomas were also obtained from many strains of mice by the transplantation of early embryos, at the egg cylinder stage (about 7 days of development) to ectopic sites (Solter et al, 1970).…”

Section: De Felici and S Dolcimentioning

confidence: 99%

From testis to teratomas: a brief history of male germ cells in mammals

Felici

Dolci²

2013

Int. J. Dev. Biol.

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In antiquity, many theories were advanced on reproduction and the functions of the gonads. The male genitalia were called "testes" probably from the Latin word "testis " that originally meant "witnesses", because they provide evidence of virility. Through the first dissection of the seminipherous tubules by Renier de Graaf (1668), the discovery of spermatozoa by Antonj van Leeuwenhoek (1677) and in vitro fertilization by Spallanzani (1780) and later by George Newport and George Vines Ellis (1854), it was only in the early part of the XIX century when it was realized that testes produce spermatozoa and that they are essential for egg fertilization and subsequent embryo development. In the period between the end of the XIX and the beginning of the XX century, scientists such as Albert von Kölliker (1817Kölliker ( -1910 KEY WORDS: germ cell, teratoma, teratocarcinoma, testis, stem cell From Aristotle to the ReinaissanceAlthough it was appreciated from the antiquity that removal of gonads had evident consequences for the fertility and behaviour of men, the anatomy and function of the gonads were essentially unknown in the ancient times. In antiquity, many theories were advanced on reproduction and the significance of the gonads. Until the Renaissance, most physicians described the male and female reproductive organs as counterparts of each other and wrote of homologous anatomical structures. Words such as "testes" were applied to both male and female reproductive organs, since it was believed that both produce substances by similar processes that contributed to generation. What that substance was became a matter of heated debate. The male genitalia were called "testes" probably from the Latin word "testis " that originally meant "witnesses", because they provide evidence of virility. In the fourth century B.C., Aristotle wrote that man contributed the form of humanity through his semen, while woman contributed only brute matter, a substance less pure and less sanctified than semen itself. Hippocrates and Galen preferred to describe human Int. J. Dev. Biol. 57: 115-121 (2013) conception as occurring from two "seeds" though they differed slightly on the relative importance of the male and female contribution. Debates about the different seeds continued throughout the Middle Ages. According to the Galenic model, both men and women were believed to have "seminal vessels" that carried semen to its point of exit. How male semen was generated was a source of speculation. Galen argued that semen came from the testes but other sources were hypothesized. Did it come from the brain via the spinal cord? Was it produced from blood? From the Renaissance onward, the development of human anatomy begun to change the traditional images of the reproductive organs and the vocabulary for the male and female bodies slowly became much more specific to each sex. At the end of the XV century, Leonardo's in his earliest anatomical drawings (about 1493) depicting sexual intercourse, admirably summarizes the traditional views of t...

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Primordial Germ Cell Proliferation in Fetal Testes in Mouse Strains With High and Low Incidences of Congenital Testicular Teratomas

Cited by 26 publications

References 0 publications

Foetal germ cells: striking the balance between pluripotency and differentiation

Foetal germ cells: striking the balance between pluripotency and differentiation

DND1 (DND microRNA-mediated repression inhibitor 1)

From testis to teratomas: a brief history of male germ cells in mammals

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