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citations
Cited by 46 publications
(32 citation statements)
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References 242 publications
(253 reference statements)
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“…Interestingly some of the gonadal cells in Dmrt1 mutants, as well as in animals heterozygous for Tfap2c and Nanos3 also fail to downregulate pluripotency markers after arrival in the genital ridge in the 129 genetic background (Krentz et al 2013, Schemmer et al 2013. In these mutants, the persistence of Nanog and Oct3/4 as well as other PGC and pluripotency marker genes like Dnd1, Prdm14, Lin28, cKit and Dppa3 counteracts apoptosis leading to rapid development of a germ cell tumor equivalent to a type I GCT, an early childhood tumor (Kehler et al 2004, Western 2009, Pirouz et al 2012. These data in mice suggest that interference with genes involved in downregulation of the pluripotency genes after arrival in the genital ridge is a critical (and error-prone) step.…”
Section: Type I and Type Ii Gcts: Results Of A Flawed Licensingmentioning
confidence: 99%
“…RNA editing is a post transcriptional key regulator of gene expression (Keegan et al, 2001) that generate alternative RNAs including mRNAs and double stranded RNAs such as are the miRNAs precursors (Nishikura, 2010). Recently, it has been reported the binding of Dnd1 to transcripts encoding negative regulators of the cell-cycle, involved in developing male germ cell mitotic arrest (Western et al, 2008), such as: p21Cip1, p27Kip1, Lats2, pRB, p53 and Pten promoting translation regulation (Cook et al, 2011) as was previously suggested (Western, 2009). Experimental deletion of Pten in PGCs drives to testicular teratomas and abnormal germ cell proliferation (Kimura et al, 2003;Moe-Behrens et al, 2003).…”
Section: Comparing Gene Expression In Pgcs and Testicular Germ Cell Nmentioning
confidence: 91%
“…So the transient activation of pRB1 in arresting germ cells may be related to the prevention of the G1/S transition. Its subsequent disappearance suggests that pRB1 activity is not necessary to maintain the quiescent state but just to induce it (Western, 2009a). Kit signalling is also downregulated when male germ cells enter mitotic arrest through the same transcriptional network that is observed in the postnatal testis (Barrios et al, 2012;Filipponi et al, 2007).…”
Section: The Molecular Programme and The Epigenetic Foundationmentioning
confidence: 97%
“…En los mamíferos todas las células derivadas desde el epiblasto, poseen la capacidad de diferenciarse hacia todos los distintos linajes celulares, es decir son células pluripotenciales (Western, 2009). Dependiendo de sus influencias regionales, vale decir, células epiblásticas anteriores, posteriores, etc., se originarán las distintas células de cada una de las tres hojas embrionarias.…”
Section: Pluripotencialidad Y Sus Marcadores En Cgunclassified
“…Это требует поддержки стромальных клеток, в частности популяции клеток Сертоли, которая возникает в ре-зультате экспрессии нейротрофического фактора гли-альных клеток (GDNF) и KITLG. Эти лиганды связы-вают RET-и KIT-рецепторы, расположенные на сперматогониях, что приводит к соблюдению баланса между самообновлением и дифференциров-кой [17].…”
unclassified