Abstract:DND1 is a RNA binding protein. Initially identified in the zebrafish, where knockdown of dnd in the early embryo resulted in loss of primordial germ cells (Weidinger et al., 2003). Mutations in Dnd1 in mice and rats, thought to result in expression of a truncated DND1 protein, are oncogenic and result in germ cell depletion as well as germ cell tumors (Youngren et al., 2005;Northrup et al., 2012). DND1 is required for the survival of primordial germ cells during early development. Primordial germ cells are the… Show more
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