Primary valvular lipomatous hamartoma: a case report and a collective review of the literature

Mitral valve lipomatous hamartoma: a rare entity

“…Crotty et al 5 reported the first review of literature about valvar hamartomas in 1991. In 2011, Karasu et al 3 published a review with nine cases of lipomatous valvar hamartomas. The majority of these masses were located in the atrioventricular valves – five cases in the mitral, four in the tricuspid valve, and only one case in the aortic valve.…”

“…Together with specific cellular patterns, encapsulation is a feature of distinction from lipomatous hamartoma. 3 Case report A 9-year-old girl presented at our department for heart murmur investigation. She was asymptomatic and had no relevant past medical history.…”

“…Lipoma, fibrolipoma, myolipoma, and angiolipoma are among fatty valvar tumours, which are well-circumscribed, encapsulated lesions, differing in their tissue composition. Together with specific cellular patterns, encapsulation is a feature of distinction from lipomatous hamartoma 3 …”

The 2021 WHO Classification of Tumors of the Heart

“…8). 18 Histologically, they consist of disorganized mature adipose tissue and fibroconnective tissue with thin-walled vasculature. This entity contrasts from cardiac lipoma by its lack of a capsule, causing it to have an infiltrative or expansive appearance on light microscopy.…”