Primary standards for measuring flow rates from 100 nl/min to 1 ml/min – gravimetric principle

Bissig, Hugo; Petter, Harm Tido; Lucas, Peter; Batista, Elsa; Filipe, Eduarda; Almeida, Nelson; Ribeiro, Luis Filipe; Gala, João; Martins, Rui F.; Savanier, B.; Ogheard, Florestan; Niemann, Anders; Lötters, Joost Conrad; Sparreboom, Wouter

doi:10.1515/bmt-2014-0145

Cited by 37 publications

(33 citation statements)

References 2 publications

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“…In MeDD I (Metrology for Drug Delivery I) [5] the aim was to prevent errors by upgrading calibration services and improving knowledge transfer to the end-user [5]. An infrastructure, consisting of traceable calibration services for drug delivery systems for flow rates down to 100 nL/min, was developed in five European National Metrology Institutes (NMIs) [7,8]. Syringe pumps and peristaltic pumps with accessories were tested [9].…”

Section: State Of the Art And Progress Beyond Itmentioning

confidence: 99%

New EMPIR project – Metrology for Drug Delivery

Batista

Furtado

Pereira

et al. 2019

19th International Congress of Metrology (CIM2019)

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This document presents the scientific and technical objectives, state of the art and expected progress beyond it, and most importantly the expected impact on metrology, science, standards, and society of the new joint research project MeDD II, Metrology for drug delivery (follow up of project MeDD I). It was selected for funding through the EURAMET EMPIR program of the European Commission and the participating countries. The project starts in June 2019 and will last for three years. It involves 15 partners from National and Designated Metrology Institutes, companies, and academia. The main objective is to enable traceable measurements of volume, flow and pressure of existing drug delivery devices (for example infusion pumps and analysers) and inline sensors that work at flow rates lower than 100 nL/min, in order to prevent inaccurate measurement results. This project will also investigate fast changing flow rates, liquid mixing behaviour and occlusion phenomena in multi-infusion systems with the purpose of improving dosing accuracy in each infusion line.

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Section: State Of the Art And Progress Beyond Itmentioning

confidence: 99%

New EMPIR project – Metrology for Drug Delivery

Batista

Furtado

Pereira

et al. 2019

19th International Congress of Metrology (CIM2019)

View full text Add to dashboard Cite

show abstract

“…In MeDD I (Metrology for Drug Delivery I) [4] the aim was to prevent errors by upgrading calibration services and improving knowledge transfer to the end-user [4]. The infrastructure, consisting of traceable calibration services for drug delivery systems for flow rates down to 100 nL/min was developed in five European National Metrology Institutes (NMIs) [6,7]. Syringe pumps and peristaltic pumps with accessories were tested [8].…”

Section: State Of the Art And Progress Beyond Itmentioning

confidence: 99%

New EMPIR project – Metrology for Drug Delivery, the role of IPQ

Batista

Ferreira

Furtado

et al. 2019

2019 IEEE International Symposium on Medical Measurements and Applications (MeMeA)

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This article presents the state of the art and expected progress beyond it, scientific objectives, and the expected impact on metrology, standards, and society of the new Joint Research Project-MeDD II, Metrology for drug delivery, selected for funding through the EURAMET (European Association of National Metrology Institutes) EMPIR (European Metrology Programme for Innovation and Research) programme of the European Commission and the participating countries. It also specifies the role of IPQ as coordinator and Work Package leader of Impact. This project will start in June 2019, for three years. It involves 15 participants from National and Designated Metrology Institutes, Companies, Hospitals and Academia and has the main objective of enabling traceable measurements of volume, flow and pressure of existing drug delivery devices (and other medical devices, like infusion pumps analysers) and inline sensors that work at a flow rate lower than 100 nL/min, in order to prevent inaccurate measurement results. This project will also investigate fast changing flow rate, liquid mixing behaviour and occlusion phenomena in multi-infusion systems with the purpose of improving dosing accuracy in each infusion line. IPQ will develop an optical method in order to decrease the validated CMC range.

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“…VSL developed a water flow standard to cover flow rates from 0.25 g/h (4.2 ȝl/min) to 5000 g/h (83.3 ml/min) with uncertainties of 0.05 % (100 -5000 g/h; 1.6 -83 ml/min), 0.10 % (5 -100 g/h; 83 -1666 ȝl/min) and 0.10 -0.3% (0.25 -5 g/h; 4.2 -83.3 ȝl/min). More details regarding the primary standards of each partner can be found in [2]. The calibration capabilities and the corresponding uncertainties of the primary standards have been validated by means of an inter-comparison organized within the project [3] for the flow rate range from 10 ml/min down to 2 ȝl/min, using a syringe pump and a Coriolis mass flow meter.…”

Section: Development Of Primary Standardsmentioning

confidence: 99%

Metrological assessment of micro flow-meters and drug delivery devices in the scope of the “MeDD” EMRP project

Ogheard¹,

Batista²,

Bissig³

et al. 2015

17th International Congress of Metrology

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Résumé. Aux échelles des micro et nano-débits de liquides, l'étalonnage revêt un caractère critique, notamment pour des applications telles que le dosage volumétrique et l'administration de médicaments. En particulier, pour des médicaments avec une très courte demi-vie (de l'ordre de la minute), ou pour des médicaments qui requièrent une très faible concentration sanguine pour des raisons de toxicité, tels que les médicaments vasoactifs ou anesthésiants, la quantité exacte de volume administré ainsi que la stabilité du débit sont cruciales. Cependant, en 2012, la traçabilité métrologique sur ces gammes de très faibles débits n'était validée en Europe qu'à partir de 16 ȝl/min. Les instituts nationaux de métrologie LNE-CETIAT, DTI, IPQ, METAS et VSL ont développé, dans le cadre du projet européen de recherche en métrologie "HLT07 Metrology for Drug Delivery -MeDD"[1], des méthodes primaires d'étalonnage couvrant une gamme de débits de liquide allant de 10 ml/min à 10 nl/min. Cet article présente les références développées dans la première partie du projet et leur validation via une inter-comparaison des résultats obtenus avec un débitmètre massique à effet Coriolis et un pousse-seringue. L'influence de plusieurs paramètres physiques tels que la température, la contre-pression, la viscosité et les pulsations du débit a été étudiée. En ce qui concerne les dispositifs de perfusion, plusieurs caractéristiques ont été testées : le délai de démarrage, la stabilité du débit et le temps de réponse à une occlusion, en fonction de la présence d'accessoires tels que des vannes, aiguilles, tubulures, et en fonction de paramètres physiques tels que la température et la viscosité du liquide. Une partie des résultats obtenus est présentée dans cet article.

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Primary standards for measuring flow rates from 100 nl/min to 1 ml/min – gravimetric principle

Cited by 37 publications

References 2 publications

New EMPIR project – Metrology for Drug Delivery

New EMPIR project – Metrology for Drug Delivery

New EMPIR project – Metrology for Drug Delivery, the role of IPQ

Metrological assessment of micro flow-meters and drug delivery devices in the scope of the “MeDD” EMRP project

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