New EMPIR project – Metrology for Drug Delivery

Abstract

This document presents the scientific and technical objectives, state of the art and expected progress beyond it, and most importantly the expected impact on metrology, science, standards, and society of the new joint research project MeDD II, Metrology for drug delivery (follow up of project MeDD I). It was selected for funding through the EURAMET EMPIR program of the European Commission and the participating countries. The project starts in June 2019 and will last for three years. It involves 15 partners from National and Designated Metrology Institutes, companies, and academia. The main objective is to enable traceable measurements of volume, flow and pressure of existing drug delivery devices (for example infusion pumps and analysers) and inline sensors that work at flow rates lower than 100 nL/min, in order to prevent inaccurate measurement results. This project will also investigate fast changing flow rates, liquid mixing behaviour and occlusion phenomena in multi-infusion systems with the purpose of improving dosing accuracy in each infusion line.

Calibration of insulin pumps based on discrete doses at given cycle times

“…The focus is on the measurement methods and the requirements for calibration of insulin pumps, which could be performed at a later stage of use to confirm their performance accuracy after a certain period of time, if necessary. This work was carried out as part of the European Metrology Program for Innovation and Research (EMPIR) Joint Research Project (JRP) 18HLT08 MeDDII, where calibration guidelines for drug delivery devices are disseminated [14].…”