Primary signet‐ring cell carcinoma of the urinary bladder inducing renal failure

Yamamoto, Shinya; Ito, Takaaki; Akiyama, Akihito; Miki, Makoto; Tachibana, Masaaki; Takase, Michio; Matsumoto, Tetsuo; Mochizuki, Masahito

doi:10.1046/j.1442-2042.2001.00280.x

Cited by 23 publications

(31 citation statements)

References 8 publications

(15 reference statements)

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“…Mucin accumulations form in the cytoplasm and nuclei are unevenly distributed [7]. Routine mucin staining of otherwise normal transitional cell carcinoma will reveal signet ring cells in many cases and the exact percentage of signet ring cells that must be present in order to make the diagnosis of PSRCC of the bladder has not been established.…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Increased frequency and nocturia in a middle aged male may not always be due to Benign Prostatic Hypertrophy (BPH): a case report

2009

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Primary signet ring cell carcinoma of urinary bladder is a rare type of bladder tumor and carries a very high mortality rate. It may have a clinical presentation similar to common diseases like Benign Prostatic Hypertrophy (BPH) and the management options are extremely limited. We report a case of 58 year old Caucasian male who presented with a 5 month history of increased frequency of urination, nocturia and weight loss without any fever or hematuria. He was found to have an increased creatinine of 2.8 mg/dl and a prostate specific antigen level of 0.18 ng/ml. His azotemia was thought to be secondary to BPH. A foley catheter was initially placed with a plan for outpatient follow up. On removal of the catheter his problems persisted and he returned to the hospital. Diagnostic work up including abdominal ultrasonography, computed tomography (CT) scan, retrograde pyelogram, cystography and cystoscopic biopsies revealed the diagnosis of primary signet ring cell carcinoma of urinary bladder. Although cystectomy was planned, our patient passed away before this could be done.

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Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Increased frequency and nocturia in a middle aged male may not always be due to Benign Prostatic Hypertrophy (BPH): a case report

2009

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“…Recently, neoadjuvant chemotherapy followed by cystectomy with lymphadenectomy has become standard care for muscle-invasive blad-der cancer [26] . However, current neoadjuvant chemotherapy or radiotherapy appears not beneficial in SRCC [8] , although intra-arterial platinum or methotrexatebased chemotherapy with or without radiotherapy to control localized disease, with prolonged progressionfree survival, has been reported [30,31] .…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics and Outcomes of Patients with Primary Signet-Ring Cell Carcinoma of the Urinary Bladder

Wang

2011

Urol Int

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Objective: The aim of this study was to examine the epidemiology, natural history, treatment pattern and predictors of long-term survival of patients with signet-ring cell carcinoma (SRCC) of the urinary bladder based on the analysis of the national Surveillance, Epidemiology, and End Results (SEER) database. Methods and Results: In total, 230 patients with pathologically confirmed SRCC of the urinary bladder were identified between 1973 and 2004. The mean age was 65 ± 13 years. Overall, 75.7% of the patients had a poorly differentiated or undifferentiated histology grade, 26.5% presented with metastatic disease, 59 (25.7%) underwent transurethral resection for bladder tumor only and 107 (46.5%) had partial or radical cystectomy. The 1-, 3- and 10-year cancer-specific survival rates were 66.8, 40.6 and 25.8%, respectively. Using multivariable Cox proportional hazard model, age (HR 1.024; p = 0.004), stage (distant vs. local, HR 6.2; p < 0.001) and cystectomy (HR 0.53; p = 0.002) were identified as independent predictors for cancer-specific survival. Conclusions: Receipt of cystectomy was strongly associated with improved survival in the patients with SRCC of urinary bladder. However, many patients with localized tumors did not receive potentially curative cystectomy. Further studies to address the barriers to the delivery of appropriate care to these patients are warranted.

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“…reported that the serum CEA levels normalized after surgery and increased as the disease progressed. [6] In our case, the serum CEA level was 0 ng/ml.…”

Section: Discussionmentioning

confidence: 55%

A case of signet ring cell adenocarcinoma of the bladder with spontaneous urinary extravasation

et al. 2011

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Primary signet ring cell adenocarcinoma (PSRCC) of the bladder is a relatively rare variant of adenocarcinoma of the bladder with poor prognosis. Also PSRCC of the bladder presenting with spontaneous urinary extravasation is very rare. We present the case of a 48-year male who presented with spontaneous urinary extravasation and was diagnosed to have PSRCC of the urinary bladder on evaluation. He was treated with radical cystectomy and adjuvant chemotherapy. This report emphasizes the need to rule out other primary sites of adenocarcinoma in the body, which may metastasize to the urinary bladder.

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Primary signet‐ring cell carcinoma of the urinary bladder inducing renal failure

Cited by 23 publications

References 8 publications

RETRACTED ARTICLE: Increased frequency and nocturia in a middle aged male may not always be due to Benign Prostatic Hypertrophy (BPH): a case report

RETRACTED ARTICLE: Increased frequency and nocturia in a middle aged male may not always be due to Benign Prostatic Hypertrophy (BPH): a case report

Clinical Characteristics and Outcomes of Patients with Primary Signet-Ring Cell Carcinoma of the Urinary Bladder

A case of signet ring cell adenocarcinoma of the bladder with spontaneous urinary extravasation

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