Primary Renal Tumors In Nonhuman Primates

Jones, S. R.; Casey, Harold W.

doi:10.1177/0300985881018s0610

Cited by 29 publications

(37 citation statements)

References 15 publications

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“…Various types of renal neoplasms of tubular epithelial origin including RCC are reported in non-human primates [27], and captive coypus [28].…”

Section: Renal Cell Carcinoma In Animalsmentioning

confidence: 99%

“…Bilateral de novo development has also been documented [13]. In nonhuman primates, few RCCs have shown evidence of metastasis [27] as is in cattle which exhibit low rate of metastasis [12].…”

Section: Malignancy and Metastasismentioning

confidence: 99%

“…In nonhuman primates, anorexia, lethargy, weight loss, depression, and dehydration are the most frequent clinical signs associated with renal neoplasms including RCC [27]. Dogs with malignant neoplasms are typically presented with a history of a palpable abdominal mass, weight loss and occasional hematuria [13,74], similar to the classical triad of hematuria, palpable mass and abdominal pain reported in humans [74].…”

Section: Clinical Signsmentioning

confidence: 99%

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Renal Cell Carcinoma in Humans and Animals: A Brief Literature Review

Woldemeskel¹

2013

J Clin Exp Pathol

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Renal Cell Carcinoma (RCC) is the most common primary renal neoplasm in humans and domestic animals such as dogs, cats and horses. Various subtypes are recognized in both humans and animals. Advances in biomedical sciences have developed hitherto unprecedented extraordinary cancer therapeutic options varying from sophisticated surgery to immunotherapy and gene therapy. Treatment regimens employed, response to treatments and prognosis vary based on the subtypes of RCC, degree of malignancy, metastasis and stage of the neoplasm. Surgery is the main treatment for most RCCs. Drug resistance has long been a challenge in cancer treatment. New insights in cancer treatment such as molecular targeted therapy including nano-medicine against chemo-resistance are among the contemporary developments targeting cancers. This mini review highlights on the occurrence and significance of RCC in humans and animals, briefly summarizes the various subtypes reported and the treatment regimens executed.

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“…Various types of renal neoplasms of tubular epithelial origin including RCC are reported in non-human primates [27], and captive coypus [28].…”

Section: Renal Cell Carcinoma In Animalsmentioning

confidence: 99%

Section: Malignancy and Metastasismentioning

confidence: 99%

Section: Clinical Signsmentioning

confidence: 99%

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Renal Cell Carcinoma in Humans and Animals: A Brief Literature Review

Woldemeskel¹

2013

J Clin Exp Pathol

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“…Previous cases of nephroblastomas in nonhuman primates have been described for both New World and Old World monkeys, among them a cynomolgus macaque, 2 baboons and 1 cotton-top tamarin. 1,4,6 In the 3 cases from Old World monkey species, the tumors exclusively affected juvenile animals, whereas the description for Saguinus oedipus referred to an adult cotton-top tamarin. The common marmoset, which also belongs to the New World monkeys, was 17 months old when the nephroblastoma was detected and was therefore close to sexual maturity.…”

mentioning

confidence: 99%

Malignant Nephroblastoma in a Common Marmoset (Callithrix jacchus)

et al. 2008

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Abstract. Necropsy of a 17-month-old male common marmoset (Callithrix jacchus) with a history of increased abdominal girth resulted in the finding of a unilateral polycystic renal neoplasm. Detailed histopathologic and immunohistochemical investigations revealed different tissue types within the tumor including stromal connective tissue and fusiform mesenchymal cell formations surrounding blastemal cells as well as different developmental stages of organ-specific epithelial cells accompanied by extensive cyst formation. Metastases were not observed. In consideration of the macroscopic, histologic, and immunohistochemical findings, the tumor was classified as a nephroblastoma closely resembling the socalled Wilms' tumor, a malignant embryonic renal tumor frequently observed in humans, especially in young children. In contrast, this tumor entity has rarely been observed in nonhuman primates. This report represents the first documented case of a cystic variant of nephroblastoma in a nonhuman primate.

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“…10 Renal carcinoma, transitional cell carcinoma, renal adenoma, adenosarcoma, nephroblastoma, nephroblastomatosis, hamartoma, transitional cell papillomatous hyperplasia, and hemangiosarcoma have been described in nonhuman primates. 7,8,10 The true incidence of primary renal tumors in nonhuman primates remains unknown and may vary among species. To our knowledge this is the first report of MESTK in an animal species other than human.…”

mentioning

confidence: 99%

A Mixed Epithelial and Stromal Tumor of the Kidney in a Ringtail Lemur (Lemur catta)

Müller

Oevermann

Wenker³

et al. 2007

Vet Pathol

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Abstract. Primary renal tumors are rare neoplasms in nonhuman primates. This report describes a mixed epithelial and stromal tumor of the kidney (MESTK) in a 14.5-year-old female ringtail lemur. The well-demarcated, solid, and cystic mass was located in the pelvis of the left kidney and consisted histologically of both epithelial and mesenchymal components. The mesenchymal cells were arranged in fascicles around cysts lined by a well-differentiated epithelium. Neither the mesenchymal nor the epithelial parts showed significant nuclear atypia or mitotic figures. To our knowledge, only 1 similar case, classified as adenoleiomyofibromatous hamartoma, has been reported in a ringtail lemur. In humans this tumor affects predominantly perimenopausal women and can express estrogen and progesterone receptors. However, neither estrogen nor progesterone receptors could be identified by immunohistochemistry in the tumor of the present ringtail lemur. Therefore, a hormonal mechanism could not be demonstrated in this case.

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Primary Renal Tumors In Nonhuman Primates

Cited by 29 publications

References 15 publications

Renal Cell Carcinoma in Humans and Animals: A Brief Literature Review

Renal Cell Carcinoma in Humans and Animals: A Brief Literature Review

Malignant Nephroblastoma in a Common Marmoset (Callithrix jacchus)

A Mixed Epithelial and Stromal Tumor of the Kidney in a Ringtail Lemur (Lemur catta)

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