A Mixed Epithelial and Stromal Tumor of the Kidney in a Ringtail Lemur (<i>Lemur catta</i>)

Müller, Sabine; Oevermann, Anna; Wenker, Christian; Altermatt, H. J.; Robert, Nadia

doi:10.1354/vp.44-2-243

Cited by 7 publications

(7 citation statements)

References 9 publications

(23 reference statements)

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“…The paramesonephric remnants, originating from the mullerian duct which has close relations to the kidney and upper urothelial tract may be the origin, and perimenopausal events or hormonal therapy against menopause may trigger tumorigenic transformation of this bud [1]. In animals, only one case of MESTK has been reported in a female Ringtail Lemur [12]. Neither estrogen nor progesterone receptors were immunohistochemically identified in this case.…”

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confidence: 72%

A Case Report of a Renal Mixed Epithelial and Stromal Tumor in a Heterozygous S1P2 Receptor Deficient Mouse

Takabatake

Takuwa

et al. 2008

The Journal of Veterinary Medical Science

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ABSTRACT. We report a case of mixed epithelial and stromal tumor of the kidney (MESTK) in a 32-week-old heterozygous sphingosine 1-phosphate-2 (S1P2) receptor deficient female mouse. A white solid mass replacing the left kidney was observed at the left retroperitoneal wall. Histologically, the tumor mass consisted of dimorphic cellular components of epithelial and stromal cells. Epithelial cells formed various sized irregular-shaped tubular structures resembling renal tubules surrounded by stromal cells. Immunohistochemically, epithelial cells were positive for cytokeratin, while stromal cells showed positive immunoreactivity with α-smooth muscle actin as well as vimentin. Based on the morphological and immunohistochemical findings, this tumor was diagnosed as a MESTK. KEY WORDS: N-ethyl-N-nitrosourea, renal mixed epithelial and stromal tumor, S1P2 deficient mouse.J. Vet. Med. Sci. 70(5): 483-485, 2008 This report describes a case of mixed epithelial and stromal tumor of the kidney (MESTK) in a female heterozygous sphingosine 1-phosphate-2 (S1P2) deficient C57BL/6N mouse of 32 weeks old. S1P2 is a member of the G proteincoupled receptor family (formerly called the EDG family) that binds and mediates a variety of actions of sphingosine-1-phosphate, a plasma-derived pleiotropic sphingolipid mediator. A heterozygous S1P2-deficient female mouse which received a single subcutaneous injection of 120 mg/ kg body weight of N-ethyl-N-nitrosourea (ENU) at 6 weeks of age was subjected to complete necropsy on 32 weeks of age. Until necropsy, this mouse did not show any abnormal clinical signs. At necropsy, a white solid mass (15 mm × 10 mm × 10 mm) replacing the left kidney without involving the surrounding tissues was observed at the left retroperitoneal wall. While 3 groups of mice including wild type mice (n=14), heterozygous S1P2 deficient mice (n=9), and homozygous S1P2 deficient mice (n=8), all given ENU, were allocated, such a renal tumor was not observed in the other ENU-treated mice. On cut section, a mass was white, firm and mottled with hemorrhagic foci. No other particular pathologic abnormalities were observed in this mouse. The mass was fixed in 10% neutral buffered formalin and processed for routine histopathology with hematoxylin and eosin. Periodic acid-Schiff (PAS) staining was also applied on this tumor. As immunohistochemical analysis, avidinbiotin-peroxidase complex (ABC) technique was applied using antibodies against α-smooth muscle actin (monoclonal mouse antibody, clone 1A4; DAKO, Glostrup, Denmark), cytokeratin (monoclonal mouse antibody, clone MFN116; DAKO), desmin (monoclonal mouse antibody, clone D33; DAKO), estrogen receptor (monoclonal mouse antibody, clone 6F11; Novocastra Laboratories, Newcastle upon Tyne, UK), vimentin (polyclonal goat antibody, product no.C-20, Santa Cruz Biotechnology, Santa Cruz, CA) and WT-1 (polyclonal rabbit antibody, product no.C-19, Santa Cruz Biotechnology). These slides were lightly counterstained with hematoxylin. Appropriate positive and negative control tissu...

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confidence: 72%

A Case Report of a Renal Mixed Epithelial and Stromal Tumor in a Heterozygous S1P2 Receptor Deficient Mouse

Takabatake

Takuwa

et al. 2008

The Journal of Veterinary Medical Science

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“…Neonatal death in captive prosimians is often (54%) related to histologically immature kidneys [Benirschke et al, 1985]. Some cases of renal tumors have been reported [Anderson et al, 1994;Yamaguchi et al, 2007], but renal neoplasms are not common [Goens et al, 2005;Jones & Casey, 1981;Muller et al, 2007]. Primary renal tumors are rare neoplasms in nonhuman primates [Muller et al, 2007].…”

Section: Introductionmentioning

confidence: 99%

“…Some cases of renal tumors have been reported [Anderson et al, 1994;Yamaguchi et al, 2007], but renal neoplasms are not common [Goens et al, 2005;Jones & Casey, 1981;Muller et al, 2007]. Primary renal tumors are rare neoplasms in nonhuman primates [Muller et al, 2007]. Studies on altered primate glomerular development [Matsell et al, 2002], renal dysplasia in rhesus monkeys [Tarantal et al, 2001], and other renal diseases in prosimians [Boraski, 1981;Glenn et al, 2006;Junge et al, 1994] and simian primates [Pinkerton, 1972;Roberts, 1972] can be found in the literature.…”

Section: Introductionmentioning

confidence: 99%

Anatomy and ultrasonography of the normal kidney in brown lemurs:Eulemur fulvus

Raharison

Mogicato

Sautet

2009

American J Primatol

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The purpose of this study is to describe the anatomy and obtain echographic measurements of normal kidneys in brown lemurs (Eulemur fulvus). The anatomical findings show that brown lemur kidneys are comparable to those of rats except for an elongated papilla. The kidneys of 16 (7 females and 9 males) lemurs were examined with two-dimensional and power Doppler ultrasonography under general anesthesia. Morphometrically, the left and right kidney surface areas are comparable (3.29 and 3.51 cm(2)). Kidney area has a significant linear correlation with body weight. Echo-Doppler findings show that the mean renal arterial blood flow speeds for the left and right kidneys are comparable (0.70 and 0.73 m/s). However, flow speed is higher in the male (0.79 m/s) than in the female (0.60 m/s). The renal arterial diameters are between 1.0 and 1.8 mm. The fact that anesthesia can have hemodynamic effects on renal vasculature should be taken into consideration when assessing these echographic results.

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“…including osteochondroma, hepatocarcinoma, cholangiocarcinoma, mixed epithelial and stromal tumour of the kidney, T-cell-rich B-cell lymphoma, osteosarcoma, malignant fibrous histiocytoma and mammary carcinoma (Chang et al, 1979;Wadsworth et al, 1980;Pye et al, 2000;Muller et al, 2007;Remick et al, 2009;Nemeth et al, 2013;Hope et al, 2015).…”

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confidence: 99%

Benign Bilateral Adenomyoepithelioma of the Mammary Gland in a Ring-tailed Lemur ( Lemur catta )

Suárez‐Bonnet

Grau-Bassas

Herráez

et al. 2017

Journal of Comparative Pathology

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A Mixed Epithelial and Stromal Tumor of the Kidney in a Ringtail Lemur (Lemur catta)

Cited by 7 publications

References 9 publications

A Case Report of a Renal Mixed Epithelial and Stromal Tumor in a Heterozygous S1P2 Receptor Deficient Mouse

A Case Report of a Renal Mixed Epithelial and Stromal Tumor in a Heterozygous S1P2 Receptor Deficient Mouse

Anatomy and ultrasonography of the normal kidney in brown lemurs:Eulemur fulvus

Benign Bilateral Adenomyoepithelioma of the Mammary Gland in a Ring-tailed Lemur ( Lemur catta )

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