Malignant Nephroblastoma in a Common Marmoset (Callithrix jacchus)

Abstract

Abstract. Necropsy of a 17-month-old male common marmoset (Callithrix jacchus) with a history of increased abdominal girth resulted in the finding of a unilateral polycystic renal neoplasm. Detailed histopathologic and immunohistochemical investigations revealed different tissue types within the tumor including stromal connective tissue and fusiform mesenchymal cell formations surrounding blastemal cells as well as different developmental stages of organ-specific epithelial cells accompanied by extensive cyst formation. Metastases were not observed. In consideration of the macroscopic, histologic, and immunohistochemical findings, the tumor was classified as a nephroblastoma closely resembling the socalled Wilms' tumor, a malignant embryonic renal tumor frequently observed in humans, especially in young children. In contrast, this tumor entity has rarely been observed in nonhuman primates. This report represents the first documented case of a cystic variant of nephroblastoma in a nonhuman primate.

Neoplasia and Proliferative Disorders of Nonhuman Primates

“…Medullary transitional cell hyperplasia and adenomas are rare incidental findings in aged rhesus macaques (Figure 6.9) and a renal papillary adenoma has been observed in a cotton-top tamarin (Brack, 1985). Bilateral undifferentiated renal sarcomas have been described in a rhesus macaque (Chrisp et al, 1985), and nephroblastoma has been described in a cynomolgus macaque (Bennett et al, 1982), a cotton-top tamarin (Jones and Casey, 1981), a common marmoset (Zoller et al, 2008), and in baboons (Goens et al, 2005). Renal adenomas, adenocarcinoma, and transitional cell carcinomas have been described in some detail in various prosimians species (Remick et al, 2009).…”

Immunohistochemical Characterization of a Renal Nephroblastoma in a <i>Trp</i>53-mutant and Prolyl Isomerase 1-deficient Mouse

“…As in humans, nephroblastomas in these animal species are mainly described in young subjects, with only a minority of cases occurring in adults. With reference to laboratory animals, nephroblastomas are commonly described in rats, both as spontaneous 12 and experimentally-induced 13 , 14 lesions, and are extremely rare in nonhuman primates 15 , 16 and mice 17 , 18 , 19 , with only few cases reported so far.…”

Nephroblastoma in a black-tufted marmoset (Callithrix penicillata)

“…Nephroblastoma is an embryonic tumor that is commonly described in humans, especially in children (Goens et al 2005). Nefroblastoma has been uncommonly described in non-human primates (NHP), such as cynomolgus monkeys (Macaca fascicularis) (Bennett et al 1982, Zoller et al 2008, baboons (Papio sp.) (Goens et al 2005), cotton-top marmosets 11:2155-2158.…”