Primary renal lymphoma: An incidental finding in an elderly male

Silverman, Ben; Levy, Joey; Vagasi, Alexandra S.; Purrazzella, Rosemary; Andaz, Shahriyour

doi:10.1016/j.eucr.2019.100965

Cited by 9 publications

(9 citation statements)

References 4 publications

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“…Early diagnosis and treatment may improve survival of PRL, but the 5-year survival rate is only around 40-50%. 32 The prognosis of PRL depends mainly on the tumor stage. 19 Using data from the SEER, Chen et al 4 demonstrated that the incidence rate of PRL has been increasing significantly.…”

Section: Discussionmentioning

confidence: 99%

Primary lymphoma of the kidney

Al-Maghrabi

2023

SMJ

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Histopathological and immunohistochemical slides were reviewed, and additional immunohistochemistry stains were carried out in selected cases. Follow-up data were also collected. Original ArticleResults: There were 17 identified cases of PRL. The age of the patients ranged from 4-76 years )median: 50.5 years and mean: 46.8 years(, 11 )64.7%( were males, and 6 )35.3%( were females. There were 12 cases of diffuse large B-cell lymphoma, 3 cases of Burkitt's lymphoma, and 2 cases of post-transplant lymphoproliferative disorder. The median follow-up duration was 22 months. The one-year overall survival rate was 71% and the 2-year overall survival rate was 43% during follow-up. Conclusion:Primary renal lymphomas in Saudi patients are more common in males and seen in a relatively younger age group compared to the available worldwide data. The diagnosis of PRL is important to avoid tumor dissemination and unnecessary nephrectomy. Diffuse large B-cell lymphoma is the most common pathological type and non-germinal center B-cell is the most common subtype.

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Section: Discussionmentioning

confidence: 99%

Primary lymphoma of the kidney

Al-Maghrabi

2023

SMJ

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“…Primary lymphoma of the kidney (PRL) is very rare, with mostly single case reports and very few case series available in English literature. [ 17 18 19 20 21 22 23 24 ]…”

Section: Discussionmentioning

confidence: 99%

“…On kidney biopsy, one was diagnosed as a high-grade T-cell lymphoma, and the other case was diagnosed as a diffuse large B-cell lymphoma, which was similar to other studies on primary renal lymphomas. [ 17 18 19 20 21 22 23 24 ]…”

Section: Discussionmentioning

confidence: 99%

Renal lymphoma diagnosed on kidney biopsy presenting as acute kidney injury

Swain¹,

Nuguri²,

Padua³

et al. 2022

Indian J Nephrol

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Introduction: Renal manifestations associated with hematolymphoid malignancies are known. Primary or secondary involvement of the kidney by lymphomatous infiltration has various clinical presentations. Acute kidney injury is not an uncommon finding in relation to lymphomatous interstitial infiltration proven on kidney biopsy. However, diagnosing it solely on renal biopsy remains a challenge and needs expertise and aid of immunohistochemistry as the prognosis is dismal. Methods: This is a retrospective study of kidney biopsy-proven cases of renal lymphoma presenting with acute kidney injury. Results: The study included 12 patients with ages ranging from 4 to 50 years who presented with serum creatinine ranging 2.1–9.6 mg%. Renal biopsy findings showed interstitial lymphomatous infiltrate. Two cases were diagnosed as primary lymphoma and the other 10 as secondary lymphomas. Among the 12 cases, nine were B-cell non-Hodgkin lymphoma, of which diffuse large B-cell lymphoma was diagnosed in six (50%), low-grade B-cell type in two (16.6%), chronic lymphocytic leukemia in one (8.3%), and three were T-cell-type. Two were acute T-cell lymphoblastic lymphoma and one other was a high-grade T-cell lymphoma. Four patients succumbed. The other four patients are alive; one is on chemotherapy, while two of them are on hemodialysis. Conclusion: Acute kidney injury as a presenting feature with lymphomatous infiltration of renal parenchyma is not uncommon. The patchy involvement makes it challenging on kidney biopsy with definitive diagnosis being made with the help of immunohistochemistry. Appropriate multidisciplinary involvement improves patient outcome.

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“…PET is also useful in monitoring response to therapy. [70][71][72][73][74][75][76] It's worthy to note again, that final diagnosis cannot be made without tissue diagnosis and histopathology is the gold standard for the diagnosis of PRNHL. 11 Immunohistochemistry is also necessary to find out about the type of NHL which is very important to select the therapeutic chemotherapy regimen.…”

Section: Discussionmentioning

confidence: 99%

“…In more than 90% of the previous case reports, nephrectomy has been performed with the preliminary impression of RCC or other common renal tumors such as oncocytoma. 74 It is difficult to make generalizations; however most studies suggest that rituximab might be a useful addition to the chemotherapeutic regimen. 14 As most of PRNHLs are high grade B cell NHLs, overall mortality is high and even new treatment modalities have not change the survival significantly.…”

Section: Discussionmentioning

confidence: 99%

Primary renal non-Hodgkin’s lymphoma: A narrative review of literature

2021

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Renal involvement by Non-Hodgkin’s lymphoma (NHL) is very rare, and involvement of the kidney as the primary site of NHL (PRNHL) is much more uncommon. Gold standard for the diagnosis of PRNHL is histology and imaging modalities although helpful are not specific. Nephrectomy has been mostly recommended for low grade lymphomas, and for high grade PRNHLs, chemotherapy without nephrectomy has been recommended as the treatment of choice. This tumor is aggressive with poor prognosis. This poor prognosis is partly because of delayed diagnosis and partly because of unnecessary surgeries, so it should be kept in mind, especially in bilateral renal tumors with unusual imaging characteristics, to take a tissue biopsy before nephrectomy. In this review, we will discuss all the detailed aspects of clinical, pathologic, and imaging characteristics of 83 cases of PRNHL reported in the last 20 years in the English literature so far. For this purpose, all the published cases of the primary non-Hodgkin’s lymphoma of kidney were reviewed via a search in PubMed, Scopus, and Google Scholar, (1999–2019), using the keywords of “Primary renal lymphoma” and “Non-Hodgkin’s lymphoma and kidney,” “renal Non-Hodgkin’s lymphoma,” “renal lymphoma,” and “lymphoma and kidney.” There were 83 cases in the published English literature which were reviewed for this article. There was some missing information in some cases which has been recorded as “not reported.”

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Primary renal lymphoma: An incidental finding in an elderly male

Cited by 9 publications

References 4 publications

Primary lymphoma of the kidney

Primary lymphoma of the kidney

Renal lymphoma diagnosed on kidney biopsy presenting as acute kidney injury

Primary renal non-Hodgkin’s lymphoma: A narrative review of literature

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