Abstract:Introduction:
Renal manifestations associated with hematolymphoid malignancies are known. Primary or secondary involvement of the kidney by lymphomatous infiltration has various clinical presentations. Acute kidney injury is not an uncommon finding in relation to lymphomatous interstitial infiltration proven on kidney biopsy. However, diagnosing it solely on renal biopsy remains a challenge and needs expertise and aid of immunohistochemistry as the prognosis is dismal.
Methods:
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“…Acute kidney injury (AKI) incited by direct cell infiltration is uncommon (10,11). Nie et al and Nuguri et al each reported only one patient with CLL/SLL and kidney injury due to associated infiltrates in recently published retrospective cohort studies of patients with lymphoproliferative disorders (12,13). AKI as the first indication that prompts the diagnosis of CLL/SLL is extremely rare, with only seven reported cases in the literature (14)(15)(16)(17)(18)(19)(20).…”
Section: Introductionmentioning
confidence: 99%
“…A second serum immunofixation 2 months later showed biclonal IgG kappa and lambda. Immunoglobulin levels were measured with a total IgA of 1.05 g/l [0.7-4], IgM of 0.18 g/l [0.4 2.3], and IgG of 8.83 g/l(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). Quantification of the…”
Chronic lymphocytic leukemia (CLL) is a lymphoproliferative disorder often diagnosed after incidental finding of leukocytosis. Renal involvement is usually clinically silent. Symptomatic renal impairment due to CLL/small lymphocytic lymphoma (SLL) cell infiltration in the kidney tissue is uncommon, and acute kidney injury (AKI) as a presenting feature is rare. In this case report, we describe the case of a patient with AKI caused by CLL/SLL infiltration as a presenting feature. Our report highlights the possibility of kidney injury as the first evident symptom of CLL/SLL. Kidney biopsy is the mainstay in these cases in order to establish a diagnosis. Treatment with zanubrutinib resulted in improved kidney function.
“…Acute kidney injury (AKI) incited by direct cell infiltration is uncommon (10,11). Nie et al and Nuguri et al each reported only one patient with CLL/SLL and kidney injury due to associated infiltrates in recently published retrospective cohort studies of patients with lymphoproliferative disorders (12,13). AKI as the first indication that prompts the diagnosis of CLL/SLL is extremely rare, with only seven reported cases in the literature (14)(15)(16)(17)(18)(19)(20).…”
Section: Introductionmentioning
confidence: 99%
“…A second serum immunofixation 2 months later showed biclonal IgG kappa and lambda. Immunoglobulin levels were measured with a total IgA of 1.05 g/l [0.7-4], IgM of 0.18 g/l [0.4 2.3], and IgG of 8.83 g/l(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). Quantification of the…”
Chronic lymphocytic leukemia (CLL) is a lymphoproliferative disorder often diagnosed after incidental finding of leukocytosis. Renal involvement is usually clinically silent. Symptomatic renal impairment due to CLL/small lymphocytic lymphoma (SLL) cell infiltration in the kidney tissue is uncommon, and acute kidney injury (AKI) as a presenting feature is rare. In this case report, we describe the case of a patient with AKI caused by CLL/SLL infiltration as a presenting feature. Our report highlights the possibility of kidney injury as the first evident symptom of CLL/SLL. Kidney biopsy is the mainstay in these cases in order to establish a diagnosis. Treatment with zanubrutinib resulted in improved kidney function.
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