Primary pulmonary choriocarcinoma combined with adenocarcinoma

Yamamoto, Sohei; Tanaka, Hiroyuki; Takeo, Hiroaki; Yasuda, Kazuyo; Mastukuma, Susumu

doi:10.1111/j.1440-1827.2006.01977.x

Cited by 25 publications

(19 citation statements)

References 35 publications

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“…Although one may question the hepatic tumor in these three cases that represent metastasis, the presence of a solitary tumor in the liver and multiple small nodules in the lung, adrenal glands, and peritoneum were more consistent with a primary hepatic choriocarcinoma with metastasis to the latter sites rather than the opposite. In addition, some carcinomas such as rectal adenocarcinoma [31], gastric adenocarcinoma [32], and lung adenocarcinoma [33] can have choriocarcinomatous differentiation. Theoretically, the choriocarcinomatous component can metastasize to the liver.…”

Section: Discussionmentioning

confidence: 99%

Primary choriocarcinoma of the liver: a clinicopathological study of five cases in males

Shi

Cao²,

Wei

et al. 2009

Virchows Arch

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Primary choriocarcinomas of the liver are rare. Previous reported cases were mostly in infants with only rare adult cases. Here, we presented five adult cases. The patients were all males, with an average age of 41.6 years (from 36 to 48 years). Clinical presentations included right upper abdominal pain or abdominal distension. All patients presented with a large hepatic mass on ultrasonography that measured 11 cm on average in the greatest diameter. Elevated serum human chorionic gonadotropin (HCG) levels were noted in all cases. At presentation, the tumor was confined to the liver in two patients and therefore surgically resected. The other three patients presented with extrahepatic metastases on imaging study and therefore only received chemotherapy. All five patients died from the tumor within 2 to 8 months. Autopsy was performed for all five cases. The autopsy confirmed that the choriocarcinoma was confined to the liver in two surgically resected cases. The other three patients had metastatic choriocarcinoma in the lung (two patients), peritoneum (one patient), adrenal glands (one patient), and brain (one patient). None of the patients had any evidence of a testicular tumor or scar after examination of the entirely submitted testes. No tumor was observed in central nervous system, mediastinum, or other organs other than described above. Grossly, the primary tumors were large, soft, hemorrhagic, and with foci of necrosis. Histologically, the tumors were composed of mononucleated trophoblastic cells with round nuclei, clear cytoplasm, and prominent nucleoli admixed with large, multinucleated syncytiotrophoblastic cells. Immunohistochemically, tumor cells were strongly positive for keratin, HCG, and focally positive for human placental lactogen. Ki-67 proliferation index was high (mean 75%) in the mononucleated trophoblastic cells. Our series is the largest one to document primary hepatic choriocarcinoma in adults. Although these tumors are rare, they behave in a very aggressive fashion.

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Section: Discussionmentioning

confidence: 99%

Primary choriocarcinoma of the liver: a clinicopathological study of five cases in males

Shi

Cao²,

Wei

et al. 2009

Virchows Arch

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“…3 Primary pulmonary location of germ cell tumor is extremely rare with less than 40 cases of choriocarcinomas and five cases of yolk sac tumors 1,4-7 have been reported thus far. A smaller number of cases have been reported as a mixture of cho- riocarcinoma with adenocarcinoma, [8][9][10] large cell carcinoma, 11,12 or small cell carcinoma. 13 In a survey performed in 2004, Umemori and his colleagues reviewed 25 previously described cases of primary pulmonary choriocarcinoma (PPC) to establish the clinical characteristics and most appropriate management of this disease.…”

Section: Discussionmentioning

confidence: 96%

“…15 In our review of the literature to date, we found four additional cases of PPC. 9,[16][17][18] Primary pulmonary yolk sac tumor is extremely rare entity. In our survey, we found only five cases reported in the English literature.…”

Section: Discussionmentioning

confidence: 99%

Aspiration biopsy cytomorphology of primary pulmonary germ cell tumor metastatic to the brain

Arabi

Shah

Saleh

2009

Diagnostic Cytopathology

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Extragonadal germ cell tumors are uncommon and such tumors originating from the lung parenchyma are extremely rare. This is a case of 68-year-old female who was admitted with complaints of right-sided weakness, inability to maintain her balance, right-sided headache, and bloody sputum. Her workup revealed two enhancing brain lesions and large lung mass involving the left lower lobe. Fine-needle aspiration (FNA) of the lung followed by craniotomy was performed and the patient was initially diagnosed with lung adenocarcinoma metastatic to the brain based on the cytomorphology of the lung FNA and histology of the brain mass. However, retrospective investigation revealed markedly elevated alpha fetoprotein (AFP) of which the cytopathologist was unaware at the time of diagnosis. A review of the cytology and surgical specimen slides, as well as immunohistochemistry (IHC) on the brain tumor and FNA cell block were preformed. On the basis of the slides review, clinical findings, and immunostaining results, a diagnosis of primary pulmonary mixed germ cell tumor, containing choriocarcinoma and yolk sac elements, with brain metastases, was retrospectively made.

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“…12 A review of the English medical literature, the terms "Pulmonary collision tumor" found cases of primary tumor of lung with another tumor like chronic lymphocytic leukemia, 13 colon, 14 choriocarcinoma, 15 non-Hodgkin lymphoma, 16 malignant melanoma, 17 metastatic adenoid cystic carcinoma, 18 breast, 19 large cell neuroendocrine carcinoma, 20 and as documented above with large cell carcinoma. 7 A PubMed search using the term pulmonary collision and carcinoid found only 3 cases with marginal zone lymphoma, 21 high-grade spindle cell sarcoma, 22 and mesothelioma.…”

Section: Discussionmentioning

confidence: 98%

Pulmonary Collision Tumor Consisting of Adenocarcinoma and Typical Carcinoid—A Case Report and Review of Literature

Abbi

Hameed

Jiang

et al. 2014

American Journal of Therapeutics

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Collision tumors are rare in nature. We report a case of a 70-year-old woman who was found to have a new mass in the right lung. Right upper and middle lobectomies with a mediastinal lymph node sampling were performed. Pathological examination of the mass revealed a collision tumor composed of micropapillary adenocarcinoma and typical carcinoid. The neoplastic cells were not intimately admixed with one another. To the best of our knowledge, this case is the first report in the English medical literature of a primary pulmonary collision tumor consisting of micropapillary adenocarcinoma and typical carcinoid.

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Primary pulmonary choriocarcinoma combined with adenocarcinoma

Cited by 25 publications

References 35 publications

Primary choriocarcinoma of the liver: a clinicopathological study of five cases in males

Primary choriocarcinoma of the liver: a clinicopathological study of five cases in males

Aspiration biopsy cytomorphology of primary pulmonary germ cell tumor metastatic to the brain

Pulmonary Collision Tumor Consisting of Adenocarcinoma and Typical Carcinoid—A Case Report and Review of Literature

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