Pulmonary Collision Tumor Consisting of Adenocarcinoma and Typical Carcinoid—A Case Report and Review of Literature

Abbi, Kamal Kant Singh; Hameed, Muhammad K.; Jiang, Yanni; Casas, Luis E. De Las; Schwann, Thomas A.

doi:10.1097/mjt.0b013e318293b0b0

Cited by 10 publications

(8 citation statements)

References 24 publications

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“…Therefore, two hypotheses regarding the pathogenesis of case 2 can be proposed: (1) both carcinoid tumor and adenocarcinoma cells were derived from the same epithelial precursor cells, and EGFR mutations occurred after differentiation into bronchioalveolar-type cells; (2) adenocarcinoma and carcinoid cells have different precursor cells and grew into synchronous collision tumors. Coexisting tumors are generally divided into two types: composite and collision tumors [ 4 , 12 ]. Composite tumors are derived from the same progenitor cell, and therefore, the two components share the same mutational status.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, the two components show different mutational status [ 12 ]. Histologically, in composite tumors, two components are intermingled and have interposed transitional tumor cells with characteristics of the two components [ 4 ]. In our cases, each nodule of the adenocarcinoma and carcinoid components was an individual nodule adjacent to each other.…”

Section: Discussionmentioning

confidence: 99%

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Coexistence of carcinoid tumor and adenocarcinoma of the lung; morphological, immunohistochemical and genetic analyses, a case report

et al. 2022

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Background Pulmonary carcinoid tumors rarely coexist with non-small cell lung carcinoma, and only nine cases have been reported previously. The pathogenesis and origin of these combined tumors remain unclear because of its rarity. Case presentation We examined two cases of adenocarcinoma coexisting with a typical or atypical carcinoid tumor: Case 1 was a 77-year-old woman and Case 2 was an 83-year-old woman. Both of these cases had no respiratory symptoms, and underwent pulmonary lobectomies due to incidentally detected lung nodules. Recurrence and metastases were not detected after the surgery. Histologically, carcinoid and adenocarcinoma components were present in both cases. The two components coexisted without mixing with each other. Next-generation sequencing was performed on the two components in these cases. In each case, no common genetic variants were detected. Conclusion We considered that our cases could histologically and genetically represent collision tumors that did not share common progenitor cells. Comprehensive analyses such as whole genome sequencing could provide important information for elucidating the pathogenesis of adenocarcinoma and carcinoid components.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Coexistence of carcinoid tumor and adenocarcinoma of the lung; morphological, immunohistochemical and genetic analyses, a case report

et al. 2022

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“…Nagamatsu et al [13] reported in 2012 a case of adenocarcinoma found in the resection of the superior lobe of the right lung, and carcinoid was detected in the central brous scar of the adenocarcinoma. Abbi et al [14] reported a case of a tumor found during resection of the superior lobe of the right lung in 2014. Postoperative pathological examination showed that the tumor was a collision tumor composed of micropapillary adenocarcinoma and typical carcinoid.…”

Section: Discussionmentioning

confidence: 99%

Lung Adenocarcinoma Complicated with a Carcinoid Microtumor: A Case Report and Literature Review

Xu¹,

He²,

Sun³

et al. 2021

Preprint

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Background: Adenocarcinoma is the most common primary lung malignant tumor. However, pulmonary carcinoid tumorlets are rare neuroendocrine tumors, and the coexistence of adenocarcinoma and pulmonary carcinoid tumorlets is extremely rare. Herein, we describe a case of lung adenocarcinoma complicated with carcinoid tumorlets.Case presentation: A 71-year-old female patient was admitted to the hospital after physical examination, multiple micronodules were in the inferior lobe of the left lung and right lung for 2 years, and a tumor was in the superior lobe of the left lung for 1 month. The patient underwent resection of the superior lobe of the left lung and wedge resection of the inferior lobe of the left lung by Video-assisted Thoracoscopic Surgery(VATS). The pathology of the superior lobe of the left lung was adenocarcinoma (pathological stage pT1cN0M0, IA3 stage), and the pathology of the inferior lobe of the left lung was carcinoid tumorlets. The patient was discharged from the hospital one week after the operation and recovered well after follow-up without recurrence.Conclusions: The lack of understanding of carcinoid tumorlets in the clinic causes their misdiagnosis or missed diagnosis. At the same time, the lack of understand also suggests that we should pay attention not only to mass-type lung tumors but also to pulmonary micronodules.

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“…Specifically, only two cases of combined NSCLC, squamous histotype, and carcinoid ( Okazaki et al, 2015 ; Owens and Fraire, 2011 ) and two cases of combined NSCLC, adenocarcinoma histotype with typical carcinoid were reported to date ( Sen and Borczuk, 1998 ; Abbi et al, 2014 ). Unfortunately, none of these cases was investigated at the molecular level, and their genetic profiles are unknown.…”

Section: Discussionmentioning

confidence: 99%

Mixed Pulmonary Adenocarcinoma and Atypical Carcinoid: A Report of Two Cases of a Non-codified Entity With Biological Profile

Parente

Rossi

Sparaneo

et al. 2021

Front. Mol. Biosci.

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Pulmonary carcinoids combined with a non-neuroendocrine component have rarely been described, and this histological subtype is not included as a specific entity in the current World Health Organization classification of pulmonary neoplasms. Here, we described the molecular and histological features of two rare cases of mixed lung neoplasms, composed of atypical carcinoid and adenocarcinoma. The targeted next-generation sequencing analysis covering single nucleotide variations, copy number variations, and transcript fusions in a total of 161 cancer genes of the two different tumor components shows a similar molecular profile of shared and private gene mutations. These findings suggest their monoclonal origin from a transformed stem/progenitor tumor cell, which acquires a divergent differentiation during its development and progression and accumulates novel, specific mutations.

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Pulmonary Collision Tumor Consisting of Adenocarcinoma and Typical Carcinoid—A Case Report and Review of Literature

Cited by 10 publications

References 24 publications

Coexistence of carcinoid tumor and adenocarcinoma of the lung; morphological, immunohistochemical and genetic analyses, a case report

Coexistence of carcinoid tumor and adenocarcinoma of the lung; morphological, immunohistochemical and genetic analyses, a case report

Lung Adenocarcinoma Complicated with a Carcinoid Microtumor: A Case Report and Literature Review

Mixed Pulmonary Adenocarcinoma and Atypical Carcinoid: A Report of Two Cases of a Non-codified Entity With Biological Profile

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