Primary ovarian undifferentiated non-small cell carcinoma, neuroendocrine type

Behnam, Kazem; Kabus, David; Behnam, Melody

doi:10.1016/j.ygyno.2003.09.031

Cited by 34 publications

(37 citation statements)

References 6 publications

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“…Then, for all 33 available LCNEC cases, we summarized the clinicopathological findings, such as patient age, FIGO stage, tumor marker values, operation and intra-abdominal findings, chemotherapy regimens and outcomes (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). The Kaplan-Meier overall survival rate was estimated by analyzing the survival time data reported in the literature with STAT view software for Windows.…”

Section: Methodsmentioning

confidence: 99%

“…The epithelial components in 29 cases of ovarian LCNEC, excluding the 4 pure type LCNEC cases, were as follows: 17 cases (56.7%) were mucinous tumors (benign, borderline malignancy and malignancy), 8 cases (26.7%) were endometrioid adenocarcinomas, 3 cases (10%) were mature cystic teratomas, 2 cases (6.7%) were adenocarcinomas, not otherwise specified, 2 cases (6.7%) were serous adenocarcinomas and 1 case (3.3%) was a benign ovarian cyst (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). In the 21 cases described for which the patients had undergone surgical treatment, 16 (76.2%) cases had complete surgery, 4 (19.0%) had optimal surgery and 1 (4.8%) had suboptimal surgery.…”

Section: Clinicopathological Features Of Lcnec -Literature Reviewmentioning

confidence: 99%

“…This cancer is also generally accompanied by surface epithelial-stromal tumors, and the LCNEC components metastasize relatively early, resulting in poor prognosis (1). To date, only 29 cases of ovarian LCNEC have been reported (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). Thus, we describe our 4 recently encountered cases and evaluate the clinicopathological features of ovarian LCNEC from 33 primary cases, including previously reported cases.…”

Section: Introductionmentioning

confidence: 99%

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Clinical features of ovarian large-cell neuroendocrine carcinoma: Four case reports and review of the literature

Oshita

Yamazaki²,

Akimoto³

et al. 2011

Experimental and Therapeutic Medicine

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Abstract. The objective of the present study was to present 4 recently encountered ovarian large-cell neuroendocrine carcinoma (LCNEC) cases, and to evaluate their clinicopathological features in the context of the previously reported 29 LCNEC cases. First, we described the clinical features of 4 recently encountered cases. Routine H&E staining and immunohistochemistry for CD56, synaptophysin and chromogranin A were performed on sections of both the LCNEC and epithelial carcinoma components. Clinical data for the total of 33 LCNEC cases were summarized, and the Kaplan-Meier survival curve was estimated. Our cases were observed in women aged 42-81 years. One case is clinically classified as FIGO stage IV with multiple metastases, and the others are classified as FIGO stages Ic, IIc and IIIb by post-surgical findings. Pathological features, assessed by H&E staining, were similar to lung LCNEC, and at least one neuroendocrine marker was positive staining in both LCNEC and the epithelial component. One case was pure type LCNEC and the others were mixed carcinoma. Paclitaxel/carboplatin chemotherapy was performed for all cases and 3 of the 4 treatments were effective. The prognoses of our cases were as follows: 1 in stage Ic died from the disease after only 2 months, but the others survived, with or without recurrence, for 32-64 months, whereas the total 5-year survival of the 33 LCNEC cases was 34.9%. In summary, our 3 LCNEC cases revealed ordinary chemo-sensitivity, resulting in a better prognosis than those previously described, apart from 1 case which exhibited aggressive behavior. For the future, a retrospective survey to elucidate the prognostic factors and prospective clinical studies to evaluate the efficacy of treatment modalities of ovarian LCNEC are necessary, particularly for aggressive LCNEC cases. IntroductionThe World Health Organization (WHO) defines large-cell neuroendocrine carcinoma (LCNEC) as a tumor with a large nucleus and a tendency to have neuroendocrine differentiation, and it defines ovarian LCNECs as miscellaneous tumors (1). In Japan, the term LCNEC was described for the first time in The General Rules for Clinical and Pathological Management of Ovarian Tumors by the Japan Society of Obstetrics and Gynecology and the Japanese Society of Pathology in December 2009. Until these classifications were established, LCNEC had been classified as anaplastic or poorly differentiated carcinoma and was synonymous with undifferentiated carcinoma of the non-small cell neuroendocrine type (1,2). According to the WHO classification of lung cancer (3), the pathological structures by H&E staining reveal a characteristic organization, such as round nest and sheet-like formation with frequently central coagulative necrosis, and rosette-like formation of tumor cells is often observed everywhere. The nucleus is large with granular or coarse chromatin, a prominent nucleolus and moderate or abundant cytoplasm. Additionally, neuroendocrine differentiation by immunohistochemical analysis, such as chromogranin A, sy...

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Section: Methodsmentioning

confidence: 99%

Section: Clinicopathological Features Of Lcnec -Literature Reviewmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical features of ovarian large-cell neuroendocrine carcinoma: Four case reports and review of the literature

Oshita

Yamazaki²,

Akimoto³

et al. 2011

Experimental and Therapeutic Medicine

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“…This extremely rare clinical presentation of a huge mass arising from an anatomically normal ovary confirmed laparoscopically, 9 months back was reiterating the fact that this tumour was rapidly growing. Some authors have similar opinion [1][2][3][4][5][6].…”

Section: Discussionmentioning

confidence: 80%

Neuroendocrine Tumors of the Female Reproductive Tract: A Literature Review

Chun¹

2015

J Pathol Transl Med

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Large cell neuroendocrine carcinoma (LCNEC) of the ovary is a rare tumor and is now included in the World Health Organization tumor classification. Its prognosis is generally very poor even when the diagnosis is made at an early stage. We report a case of pure large cell neuroendocrine tumour of ovary, appearing 9 months following laparoscopic type I hysterectomy, bilateral pelvic lymph node dissection with ovarian preservation of anatomically normal looking ovaries performed for a cervical biopsy diagnosis of cervical intraepithelial neoplasia grade III with foci of invasion. The rarity lies in the rapid onset (9 months) of a large tumor following conservation of an anatomically normal ovaries. Surgical debulking and five cycles of chemotherapy (Etoposide and Cisplatin) were administered to the woman. She is on followup with no clinical or radiological evidence of disease recurrence for 6 months.

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“…It appears that non-small cell neuroendocrine carcinoma is associated with aggressive behaviour (Behnam et al 2004). …”

Section: Discussionmentioning

confidence: 99%