Neuroendocrine tumour of the ovary

Aslam, Mohammad; Choi, Chang-Won; Khulpateea, Neekianund

doi:10.1080/01443610902946903

Cited by 16 publications

(12 citation statements)

References 8 publications

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“…Although sporadic studies from case reports and small case series have been performed, epidemiologic information and precise recommendations for management of ovarian neuroendocrine carcinoma are still limited and inadequate for accurate clinical diagnosis and treatment 9–11. Hence, we performed a multicenter, population-based investigation with the aim of assessing the epidemiologic and prognostic data for neuroendocrine carcinoma of the ovary.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathologic characteristics and survival outcomes in neuroendocrine carcinoma of the ovary

Zhu

Meng

Fang

et al. 2019

Int J Gynecol Cancer

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ObjectiveNeuroendocrine tumors are rare in the ovary. Definitive epidemiologic and prognostic information for neuroendocrine carcinoma of the ovary is lacking. This retrospective population-based study aimed to elucidate the demographic and clinicopathologic characteristics of neuroendocrine carcinoma of the ovary.MethodsPatients with neuroendocrine carcinoma of the ovary diagnosed between January 1994 and December 2014were identified from the Surveillance, Epidemiology, and End Results (SEER) database of the National Cancer Institute. Cancer-specific survival was calculated by Kaplan-Meier plots and comparisons were performed using the log-rank test. A Cox hazard regression analysis was performed to identify independent predictors of cancer-specific survival in patients with neuroendocrine carcinoma of the ovary.ResultsA total of 166 patients were included, and 21.1% were younger than 50 years old. The majority of patients (59.6%) presented with unilateral tumors. Patients with neuroendocrine carcinoma of the ovary had significantly worse survival compared with most subtypes of epithelial ovarian cancer (including serous, endometrioid, mucinous, and clear cell), and similar to ovarian carcinosarcoma. The rate of cancer-specific survival was significantly different under the SEER histologic stages. Patients with low-grade neuroendocrine carcinoma of the ovary had longer average survival times than those with high-grade neuroendocrine carcinoma of the ovary (HR 3.43, 95% CI 1.56 to 7.54, p=0.002). Patients with neuroendocrine carcinoma of the ovary who underwent surgery had significantly better survival than those who did not undergo surgery (HR 2.23; 95% CI 1.45 to 3.43, p=<0.05).ConclusionsEarly clinical stage and low tumor grade independently predict better survival in patients with neuroendocrine carcinoma of the ovary. Surgery may be a useful therapy for neuroendocrine carcinoma of the ovary.

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Section: Introductionmentioning

confidence: 99%

Clinicopathologic characteristics and survival outcomes in neuroendocrine carcinoma of the ovary

Zhu

Meng

Fang

et al. 2019

Int J Gynecol Cancer

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“…This extremely rare clinical presentation of a huge mass arising from an anatomically normal ovary confirmed laparoscopically, 9 months back was reiterating the fact that this tumour was rapidly growing. Some authors have similar opinion [1][2][3][4][5][6].…”

Section: Discussionmentioning

confidence: 82%

Neuroendocrine Tumors of the Female Reproductive Tract: A Literature Review

Chun¹

2015

J Pathol Transl Med

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Large cell neuroendocrine carcinoma (LCNEC) of the ovary is a rare tumor and is now included in the World Health Organization tumor classification. Its prognosis is generally very poor even when the diagnosis is made at an early stage. We report a case of pure large cell neuroendocrine tumour of ovary, appearing 9 months following laparoscopic type I hysterectomy, bilateral pelvic lymph node dissection with ovarian preservation of anatomically normal looking ovaries performed for a cervical biopsy diagnosis of cervical intraepithelial neoplasia grade III with foci of invasion. The rarity lies in the rapid onset (9 months) of a large tumor following conservation of an anatomically normal ovaries. Surgical debulking and five cycles of chemotherapy (Etoposide and Cisplatin) were administered to the woman. She is on followup with no clinical or radiological evidence of disease recurrence for 6 months.

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“…The epithelial components in 45 cases of ovarian LCNEC, excluding the seven pure-type LCNEC cases, were as follows: 18 mucinous tumours (benign, borderline malignancy and malignancy), eight endometrioid adenocarcinomas, four mature cystic teratomas, two adenocarcinomas, not otherwise specified, two serous adenocarcinomas, one benign ovarian cyst and three undifferentiated non-small cell neuroendocrine carcinoma [Table] (3−25). Of these, only two cases of adenocarcinoma as surface-epithelial components have been described (4,9). Our patient is important as she is only the third case in which adenocarcinoma as surface-epithelial components is present.…”

Section: Discussionmentioning

confidence: 86%

Large Cell Neuroendocrine Carcinoma of the Ovary and its Skin Metastases: A case report and review of the literature Ovarian Large Cell Neuroendocrine Carcinoma

Cokmert¹,

Demir²,

Doğanay³

et al. 2014

West Indian Med J

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Large cell neuroendocrine carcinoma in the gynaecological organs affects the uterine cervix and ovary. Large cell neuroendocrine carcinoma of the ovary is extremely rare, and prognosis is quite poor even when diagnosed at an early stage. These tumours respond poorly to standard chemotherapy regimens. The clinical observation of skin metastasis in patients with epithelial ovarian cancer is relatively uncommon, occurring in only 3.5% of patients. These lesions are observed mostly in skin of the abdominal wall adjacent to the primary ovarian tumours. Metastatic skin lesions on extremities are much more rare; it is reported that only 12% of epithelial ovarian carcinoma skin metastases occur on the limbs. Skin metastasis due to large cell neuroendocrine carcinoma of the ovary has not been previously reported. We report the case of a large cell neuroendocrine tumour of the ovary with skin metastases on extremities appearing two months after surgery in a 68-year old woman.

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Neuroendocrine tumour of the ovary

Cited by 16 publications

References 8 publications

Clinicopathologic characteristics and survival outcomes in neuroendocrine carcinoma of the ovary

Clinicopathologic characteristics and survival outcomes in neuroendocrine carcinoma of the ovary

Neuroendocrine Tumors of the Female Reproductive Tract: A Literature Review

Large Cell Neuroendocrine Carcinoma of the Ovary and its Skin Metastases: A case report and review of the literature Ovarian Large Cell Neuroendocrine Carcinoma

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