Primary osteosarcoma of the urinary bladder treated with external radiotherapy in a patient with a history of transitional cell carcinoma: a case report

Abstract

IntroductionPrimary osteosarcoma is one of the rare tumors affecting the urinary bladder. The occurrence of osteosarcoma in a patient with a long history of transitional cell carcinoma of the bladder is even more uncommon.Case presentationWe present the case of a 74-year-old Greek man who was diagnosed with osteosarcoma 10 years after he had been diagnosed with transitional cell carcinoma of the bladder from which he had been free from recurrences for the past three years. Our patient was treated for the osteosarcoma with transurethral resection of bladder tumor and external beam radiation therapy. He died eight months after the diagnosis, suffering poor quality of life in the last months.ConclusionOsteosarcoma of the bladder has a dismal prognosis. External beam radiation therapy as an adjunct to transurethral resection of bladder tumor not only provides no benefit to patients with primary osteosarcoma of urinary bladder, but also may be associated with poor quality of life.

A Rare Case of Primary osteosarcoma of urinary bladder

“…Vimentin[6] and p53 are strongly expressed in more than 95% of the neoplastic cells. In our case, vimentin was diffusely positive and cytokeratin was negative.…”

Primary localized amyloidosis of urinary bladder: Case report

“…Kondroid metaplazi mesanede, özellikle tümör olgularında rastlanabilen bir bulgudur. 11,12,13 Taşdemir ve arkadaşlarının 14 sunduğu benzer bir olguda ise mesane tümörünü taklit ederek hematüriye neden olan eozinofilik sistit olgusu sunulmuştur.…”

Carcinosarcoma of the bladder: case report and review of the literature

“…[11][12][13][14][15] Carcinosarcomas with osteogenic components are extremely uncommon, with about 40 cases reported in the literature. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] In 1856, Ordonez recorded the first report of a malignant bladder tumour containing elements of cartilage or bone. 12 This first case report gives few clinical details and deals chiefly with the histologic structure, which today would be classified as a chondrosarcoma.…”

“…The third reported case was from Beneke in 1899. [14][15][16][17][18][19][20][21][22][23][24]30,31 This case was different from the 2 prior cases in that it consisted of both bone and cartilage. About 100 years later, a case was reported and the literature was reviewed for the first time in 1943 by Crane and Tremblay.…”

“…1 About 35 well-documented cases having been reported in the English literature to date. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] The presence of both a carcinomatous and sarcomatous component in the bladder is termed a carcinosarcoma. This case is unique in that a transurethral resection of bladder tumour (TURBT) resulted in complete resection of the sarcoma component of the bladder, with an ultimate radical cystoprostatectomy specimen showing no osteosarcoma, but only residual carcinoma in situ (CIS).…”