A Rare Case of Primary osteosarcoma of urinary bladder

Abstract

Extraskeletal osteosarcoma is a malignant mesenchymal soft tissue tumor without attachment to the bone, and is able to produce osteoid or cartilaginous matrix. This entity accounts for 1% of all soft tissue sarcomas. Thus far, less than 35 cases of bladder osteosarcomas have been reported in the literature. These tumors are associated with very poor prognosis. We report a case of primary osteosarcoma of the urinary bladder presenting with intermittent hematuria, dysuria, and right flank pain. Contrast-enhanced computed tomography scan of the abdomen, pelvis, and chest revealed a bladder mass and pulmonary metastases with specks of calcification.

Primary Exophytic Extraskeletal Osteosarcoma of the Liver: A Case Report and Literature Review

“…It constitutes less than 4% of all types of osteosarcoma, and it can form bone-like or cartilagelike materials, which is similar to osteosarcoma histologically. [1][2][3] It occurs predominantly in elderly patients, and the mean age has been reported as 54 years. 5 Though ESOS most commonly affects legs and hips, there are case reports of it occurring in the thyroid, kidney, gallbladder, bladder, breast, uterus, and lung.…”

“…It constitutes less than 4% of all types of osteosarcoma, and it can form bone-like or cartilage-like materials, which is similar to osteosarcoma histologically. [1][2][3] The absence of a primary bone lesion is a prerequisite for the diagnosis of ESOS. 4 We report the case of an elderly male patient with primary hepatic exophytic ESOS that was treated by surgical resection and adjuvant chemotherapy.…”

A Rare Primary Osteogenic Sarcoma of the Prostate and Bladder

“…Of extraskeletal osteosarcomas, those involving the genitourinary tract are rare and account for 0.04% and to date, there have been 35 documented cases [1]. The tumor presents with hematuria and has a 4:1 male to female predominance.…”

“…Histological staining for osteosarcoma is negative for pan-cytokeratin 7 and 20, epithelial membrane antigen, smooth muscle actin, desmin, CD34, and CD68. It strongly expresses vimentin and p53 [1]. Osteoid elements are present with mature lamellar structures, keratin, and desmosomes [2].…”

“…Treatment includes Bacille Calmette-Guerin for superficial malignancy and a combination of radical cystectomy, chemotherapy, and radiation for invasive tumors. Contributing factors to morality include continued local invasion, urinary obstruction, uremia, infection, and pulmonary metastasis [1]. Rare anecdotal cases report survival of 36-51 months with a combination of partial or radical cystectomy with chemotherapy [7].…”