Primary osteosarcoma of the breast: Imaging and histological features

Brown, Ann L.; Holwill, Stephen; Thomas, Val; Sacks, N. P. M.; Given-Wilson, Rosalind

doi:10.1016/s0009-9260(98)80224-9

Cited by 16 publications

(14 citation statements)

References 8 publications

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“…As reported in the literature, primary breast OS mainly occurs in females of >60 years, which is consistent with the observation in the present case (1,5–7,11–14). The malignancy has also been observed in younger females (1,4,8,15,16).…”

Section: Discussionsupporting

confidence: 93%

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Primary osteosarcoma of the breast: A case report

et al. 2014

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Osteosarcoma (OS) located in the breast is an extremely rare, malignant neoplasm. The current study presents the diagnostic process, treatment and follow-up of a 67-year-old female with OS of the breast. The diagnosis was made according to diagnostic imaging methods and microscopic examination with additional immunohistochemical staining. As a surgical treatment, tumourectomy with intraoperative histological examination and simple breast amputation was performed. No adjuvant chemotherapy was administered following surgery. Lung and bone metastases occurred without local recurrence 14 months following the surgery. In the present study, the details of the diagnostic examinations performed are evaluated and the consecutive phases of diagnostic and therapeutic proceedings are examined in comparison with the knowledge in the literature.

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Section: Discussionsupporting

confidence: 93%

“…Similar to the radiology examinations of the current patient, in mammography imaging, OS presents as a well-circumscribed, oval and firm calcified mass (6–8,11–15). In USG imaging, the tumour may be observed with blurred outlines, heterogeneous echogenicity and focal calcification (8,11,14,15). …”

Section: Discussionmentioning

confidence: 99%

Primary osteosarcoma of the breast: A case report

et al. 2014

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“…Many cases have been described in association with fibroadenoma or a phyllodes tumor 1,2 . Primary breast osteosarcoma without association of a biphasic tumor is rare 3–5 . In this report we present a case that was originally thought to be pure osteosarcoma of the breast.…”

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confidence: 88%

Primary osteosarcoma of the breast

Murakami

Isozaki

Shou

et al. 2009

Pathology International

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Presented herein is a case of primary pure osteosarcoma of the breast. A 59-year-old woman noticed a left breast tumor. Mammography showed a cluster of crushed stone-like calcifications, which gave the tumor a raw cotton-like appearance. Malignancy was suspected on fine-needle aspiration cytology of the tumor. An excisional biopsy was performed. The tumor was 2.0 x 2.4 cm in size. Histopathologically the tumor was composed of diffuse atypical cells with mitosis and a lot of bone. Atypical cells were thought to be neoplastic osteoblasts. Multinucleated osteoclastic cells were interspersed with osteoblasts. Spindle cells were found at the verge of the tumor. A few entrapped tubular structures were seen. Immunohistochemistry indicated that neoplastic osteoblastic cells of the tumor were stained positively for vimentin, but negatively for epithelial markers; which suggested that the tumor cell elements originated from epithelial cells. This tumor was diagnosed as primary extraskeletal osteosarcoma. Partial resection was additionally performed around the excisional biopsy without dissection of the axillary lymph nodes. Bone radionuclide scan after operation showed no abnormal uptake. At 5 years after surgery no recurrence was seen.

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“…High level of serum alkaline phosphatase has been documented which suggests bone forming neoplasms and also correlates with high histochemical expression in the tumor and has been noted to decline following excision [5,11] hence useful in follow up [15]. Serum alkaline phosphatase was not measured in our case.…”

Section: Discussionmentioning

confidence: 67%

Primary Osteosarcoma of the Breast- A Case Report and Review of Literature

2011

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Primary Osteosarcoma of the breast is an aggressive and relatively rare tumour whose prognosis is very poor.It is often a diagnostic dilemma to the pathologists and the surgeons are perplexed due to its aggressive behaviour as its pathology and prognostic factors are unclear. Due to its rarity we suggest pooling of tissue samples from various centres in biobanks for future studies (including molecular biological studies) so that its behaviour can be better understood.

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Primary osteosarcoma of the breast: Imaging and histological features

Cited by 16 publications

References 8 publications

Primary osteosarcoma of the breast: A case report

Primary osteosarcoma of the breast: A case report

Primary osteosarcoma of the breast

Primary Osteosarcoma of the Breast- A Case Report and Review of Literature

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