Primary Osteosarcoma of the Breast- A Case Report and Review of Literature

Abstract

Primary Osteosarcoma of the breast is an aggressive and relatively rare tumour whose prognosis is very poor.It is often a diagnostic dilemma to the pathologists and the surgeons are perplexed due to its aggressive behaviour as its pathology and prognostic factors are unclear. Due to its rarity we suggest pooling of tissue samples from various centres in biobanks for future studies (including molecular biological studies) so that its behaviour can be better understood.

Primary breast osteosarcoma: a case report and review of literature

“…fibroadenoma or phylloides tumour), previous trauma and exposure to radiation, have also been correlated with the development of PBO. 1,4,5,7–14…”

Primary osteosarcoma of the breast with abundant chondroid matrix and fibroblasts has a good prognosis: A case report and review of the literature

“…Primary breast osteosarcomas are considered to be highly aggressive tumors associated with early recurrence and a tendency for hematogenous, instead of lymphatic, spread, most commonly to the lungs (2,3,6,8–11). …”

“…In comparison, bone-producing spindle cell neoplasms with an epithelial origin, known as metaplastic (sarcomatoid) carcinomas, and malignant phyllodes tumors are more common (7). Primary breast osteosarcomas are considered to be highly aggressive tumors that are associated with early recurrence and a tendency for hematogenous, instead of lymphatic, spread, most commonly to the lungs (2,3,6,8–11). The tumor subtype, size and mitotic figures may be predictors of prognosis.…”