Primary breast osteosarcoma: a case report and review of literature

Samaraee, Ahmad Al; Angamuthu, Nithia; Fasih, Tarannum

doi:10.1177/0036933014551674

Cited by 4 publications

(3 citation statements)

References 19 publications

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“…As mentioned in the Introduction, primary breast osteosarcoma is a rare malignancy, with approximately 100 cases described in the existing literature through isolated case reports and small case series [3] , [4] , [5] , [6] . Many of the published case reports have shown large calcified masses that presented as palpable abnormalities.…”

Section: Discussionmentioning

confidence: 99%

Primary breast osteosarcoma mimicking calcified fibroadenoma on screening digital breast tomosynthesis mammogram

Bennett

Merenda

Schnepp

et al. 2017

Radiology Case Reports

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Primary breast osteosarcoma is a rare malignancy, with mostly case reports in the literature. The appearance of breast osteosarcoma on digital breast tomosynthesis imaging has not yet been described. A 69-year-old woman presents for routine screening mammography and is found to have a calcified mass in her right breast. Pattern of calcification appeared “sunburst” on digital breast tomosynthesis images. This mass was larger than on the previous year's mammogram, at which time it had been interpreted as a benign calcified fibroadenoma. The subsequent workup demonstrated the mass to reflect primary breast osteosarcoma. The patient's workup and treatment are detailed in this case. Primary breast osteosarcoma, although rare, should be included as a diagnostic consideration for breast masses with a sunburst pattern of calcifications, particularly when the mammographic appearance has changed.

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Section: Discussionmentioning

confidence: 99%

Primary breast osteosarcoma mimicking calcified fibroadenoma on screening digital breast tomosynthesis mammogram

Bennett

Merenda

Schnepp

et al. 2017

Radiology Case Reports

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“…Immunohistochemistry indicated the presence of vimentin without epithelial markers [23] . The diagnostic criteria for osteosarcoma is the absence of epithelial component in the tissue with neoplastic osteoid element [20,24–28] .…”

Section: Primary Osteosarcoma Of the Breastmentioning

confidence: 99%

Rare breast malignancies and review of literature: A single centres experience

Angamuthu

Fasih

2015

International Journal of Surgery Case Reports

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HighlightsLymphoma of the breast is best managed with chemotherapy rather than surgery.Supradiaphragmatic metastases of ovarian cancer to breast can significantly alter prognosis.Osteosarcoma requires total excision with adequate margins in order to determine tumour size which is a valuable prognostic factor for survival.Immunohistochemistry is helpful to distinguish metaplastic carcinoma which are aggressive and are associated with poor outcomes.Adenoid cystic carcinoma of the breast are associated with favourable prognosis that only require surgery.

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“…Over a period of 18 years, Jernstorm et al (4) observed only one case of osteosarcoma in 3,319 cases of mammary carcinoma. Treatment for localized disease includes complete surgical removal of the tumor with an adequate margin, whereas chemotherapy is the main treatment for metastatic osteosarcoma (5). To the best of our knowledge, there is no standard adjuvant treatment for breast osteosarcoma at present.…”

Section: Introductionmentioning

confidence: 99%

Evolution and prognosis of breast osteosarcoma: A case report

et al. 2015

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Abstract. Breast osteosarcoma is a rare malignancy of unknown etiology, with no standard adjuvant treatment at present. The prognosis of the disease is poor, and it has a high propensity for recurrence and metastasis. The current report presents the case of a 52-year-old woman, in whom adenomyoepithelioma gradually developed into breast osteosarcoma following three separate surgeries. The patient survived for 41 months from the initial lesion occurrence and resection in the left breast; during this time, she underwent surgery and chemotherapy (liposomal doxorubicin and cisplatin) for the treatment of disease recurrence and lung metastasis, along with molecular-targeted therapy (sunitinib). However, the patient eventually succumbed to respiratory failure due to progressive disease. The present case underwent a clear pathological transformation process, and may provide a basis for an improved understanding of the clinical characteristics and treatment of breast osteosarcoma.

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Primary breast osteosarcoma: a case report and review of literature

Abstract: Primary breast osteosarcoma is a rare breast malignancy that affects elderly patients. Diagnosis is often challenging and can be debatable due to its rarity, non-specific radiological findings and the complicated histopathological subtypes. Surgery is the treatment of choice.

Cited by 4 publications

References 19 publications

Primary breast osteosarcoma mimicking calcified fibroadenoma on screening digital breast tomosynthesis mammogram

Primary breast osteosarcoma mimicking calcified fibroadenoma on screening digital breast tomosynthesis mammogram

Rare breast malignancies and review of literature: A single centres experience

Evolution and prognosis of breast osteosarcoma: A case report

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