Primary osteosarcoma of the breast: A case report

Szajewski, Mariusz; Kruszewski, Wiesław Janusz; Ciesielski, Maciej; Smiałek-Kusowska, Urszula; Czerepko, Maksymilian; Szefel, Jarosław

doi:10.3892/ol.2014.1981

Cited by 16 publications

(17 citation statements)

References 19 publications

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“…Surgery in the form of wide excision aimed at achieving negative margins remains the cornerstone of management of primary breast osteosarcomas. [ 1 3 7 8 9 10 11 ] Lymph node dissection is not indicated, except when clinically involved. The effectiveness of adjuvant radiotherapy and chemotherapy however remains unclear.…”

Section: Discussionmentioning

confidence: 99%

“…It has been used either singly or in combination by various authors in an attempt to reduce the local and systemic recurrences. [ 8 9 ] The prognosis of breast osteosarcomas unlike breast sarcomas and breast carcinomas is poor. [ 9 ] Primary breast osteosarcomas are considered to be highly aggressive neoplasms with early recurrences and propensity for hematogenous spread, the 5-year survival rate has been reported at a dismal 38%.…”

Section: Discussionmentioning

confidence: 99%

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Primary breast osteosarcoma: A diagnostic challenge

Krishnamurthy

2015

Indian J Nucl Med

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Extraskeletal osteosarcomas account for < 1% of the soft tissue sarcomas and are known to more often localize in soft tissues of the lower extremities. Primary osteosarcomas of the breast are extremely rare. A majority of the reported cases were in fact initially erroneously diagnosed and treated as primary breast carcinomas. We recently got to treat an interesting case of a primary breast osteosarcoma and discuss its evaluation and management with added emphasis on the incremental role of technetium 99-methylene diphosphonate (Tc-99m) bone scintigraphy in its clinical diagnosis. Tc-99m uptake can occasionally be seen in the delayed bone scintigraphy images of extra skeletal malignancies, but the uptakes are considered to be typically less intense than the uptakes noted in primary skeletal malignancies. Extraskeletal osteosarcomas are however the exceptions to this rule, the intense uptake in bone scintigraphy further aided in an accurate preoperative diagnosis and management of our patient.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Primary breast osteosarcoma: A diagnostic challenge

Krishnamurthy

2015

Indian J Nucl Med

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“…Chemotherapeutic drugs (including, doxorubicin, cyclophosphamide and cisplatin) may prolong survival in patients exhibiting primary osteosarcoma; however, this has not been demonstrated in cases of breast osteosarcoma (11,16,17). In the present case, liposomal doxorubicin and cisplatin chemotherapy were selected for treatment of the patient, and an SD response evaluation was achieved.…”

Section: Discussionmentioning

confidence: 99%

Evolution and prognosis of breast osteosarcoma: A case report

et al. 2015

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Abstract. Breast osteosarcoma is a rare malignancy of unknown etiology, with no standard adjuvant treatment at present. The prognosis of the disease is poor, and it has a high propensity for recurrence and metastasis. The current report presents the case of a 52-year-old woman, in whom adenomyoepithelioma gradually developed into breast osteosarcoma following three separate surgeries. The patient survived for 41 months from the initial lesion occurrence and resection in the left breast; during this time, she underwent surgery and chemotherapy (liposomal doxorubicin and cisplatin) for the treatment of disease recurrence and lung metastasis, along with molecular-targeted therapy (sunitinib). However, the patient eventually succumbed to respiratory failure due to progressive disease. The present case underwent a clear pathological transformation process, and may provide a basis for an improved understanding of the clinical characteristics and treatment of breast osteosarcoma.

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“…Some reports have suggested that the tumor arises from totipotent mesenchymal cells of the breast stroma or the transformation of a preexisting fibroadenoma or phyllode tumor [2,[5][6][7]. Unfortunately, primary breast osteosarcoma is considered a poor prognosis cancer with early tumor recurrence and a propensity for hematogenous rather than lymphatic spread most commonly to the lungs [7][8][9]. We present the case of a 65-year-old Caucasian woman who was diagnosed with an osteosarcoma in her right breast.…”

Section: Introductionmentioning

confidence: 99%