Primary Osteosarcoma of the Breast—Case Report and Review of the Literature

Kaiser, Ulrich; Barth, Peter; Duda, Volker; Pflüger, Karl-Heinz; Havemann, K.

doi:10.3109/02841869409098383

Cited by 18 publications

(17 citation statements)

References 11 publications

(4 reference statements)

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“…The value of axillary lymph node resection is not clearly defined, since osteogenic sarcomas rarely cause lymph node metas tases. However, in addition to our patient two further cases of osteogenic sarcomas of the breast with lymph node metastases were reported, and in addition four of six patients with pri mary exogenous osteosarcoma of the thoracic wall also had positive axillary lymph nodes [6,13,15]. Whether the lymphat ic nodes were involved by direct spread of the tumour or by lymphatic metastases in the latter cases cannot be clearly sepa rated.…”

Section: Discussion and Review Of The Literaturementioning

confidence: 81%

“…In addi tion all 4 patients treated with postoperative radiation therapy died of progressive disease [27,30,33,34]. Six patients in cluding our own had received combination chemotherapy [15,28,29,32,36]. The median survival of these patients was 30 months, and 2 patients have been long-term disease-free survivors after treatment with high-dose methotrexate, bleomycin, cyclophosphamide, DTIC and adriamycin in one case and with cisplatin, adriamycin and ifosfamide in the other [36,37].…”

Section: Discussion and Review Of The Literaturementioning

confidence: 99%

“…A tendency towards early haematogenous spread seems to be common among all extraosseous osteosarcomas and can also be observed in cases of osteosarcomas of the breast [8,13]. The initial staging procedures should include CT scans of the thorax, abdominal ultrasound and bone scans to exclude skele tal lesions [24], Laboratory investigations should include the determination of alkaline phosphatase levels, although eleva tion of this parameter was reported only in one case of primary osteosarcoma of the breast [24], In cases where a detailed his tological evaluation was performed a high number of mitoses per high power field and the presence of numerous cellular atypias were probably indicators of a poor prognosis [8,10,13,15,22], For most cases of osteogenic sarcoma of the breast a tendency towards multiple local recurrences and metastatic disease was reported. The current case demonstrates the rapid growth of the tumour which was diagnosed only weeks after a normal gynaecological routine examination.…”

Section: Discussion and Review Of The Literaturementioning

confidence: 99%

“…Sarcomas may only constitute up to 0.5% of all malig nancies of the breast, and 10 to 15% of these are osteogenic in nature [14]. In the literature only 19 cases of primary osteosar coma of the breast have been reported [15]. In many cases the diagnosis has only been made by histological examination of tumour during surgery.…”

Section: Introductionmentioning

confidence: 99%

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Primary Osteogenic Sarcoma of the Breast: Report of a Case and a Short Review of the Literature

1995

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Background: Extraosseous osteosarcoma is a rare disease with approximately 150 cases reported in the literature. Primary osteogenic sarcoma of the breast is considered a particularly rare localisation. Approximately 20 cases of osteogenic sarcoma of the breast have been reported in the literature. The radiographic findings of the primary lesion are often misinterpreted as benign fibroadenomas the diagnosis of this rare disease is based on histological criteria. Osteogenic sarcomas of the breast have a high tendency towards local recurrences early haematogenous pread particularly pulmonary metastases. Case Report: Osteogenic sarcoma of the breast was diagnosed in a 48-year-old woman. Following mastectomy axillary lymph node dissection the patient developed liver thoracic wall metastases. She obtained a complete remission to COSS-86 chemotherapy but subsequently relapsed died from disseminated tumour despite repeated surgical attempts postoperative radiotherapy palliative chemotherapy 24 months after the primary diagnosis. Conclusions: Based on the currently available data of the cases reported radical resection of the primary tumour including axillary lymph node dissection is probably the appropriate surgical approach for primary osteogenic sarcoma of the breast. Since chemosensitivity of this malignancy has been observed adjuvant treatment according to the regimens employed for the treatment of osteogenic sarcoma of the bone (COSS treatment protocol) is recommended in order to improve the otherwise poor prognosis of patients with osteogenic sarcoma of the breast.

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Section: Discussion and Review Of The Literaturementioning

confidence: 81%

Section: Discussion and Review Of The Literaturementioning

confidence: 99%

Section: Discussion and Review Of The Literaturementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Primary Osteogenic Sarcoma of the Breast: Report of a Case and a Short Review of the Literature

1995

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“…Applying this option is not standard treatment for the management of breast OS patients due to the limited number of clinical trials where polychemotherapy has been used in cases of this extremely rare tumour (1,4–6,11–15). In a situation where tumour-free surgical margins cannot be obtained, postoperative radiotherapy is sometimes advisable (4,5,8,19–20). …”

Section: Discussionmentioning

confidence: 99%

Primary osteosarcoma of the breast: A case report

et al. 2014

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Osteosarcoma (OS) located in the breast is an extremely rare, malignant neoplasm. The current study presents the diagnostic process, treatment and follow-up of a 67-year-old female with OS of the breast. The diagnosis was made according to diagnostic imaging methods and microscopic examination with additional immunohistochemical staining. As a surgical treatment, tumourectomy with intraoperative histological examination and simple breast amputation was performed. No adjuvant chemotherapy was administered following surgery. Lung and bone metastases occurred without local recurrence 14 months following the surgery. In the present study, the details of the diagnostic examinations performed are evaluated and the consecutive phases of diagnostic and therapeutic proceedings are examined in comparison with the knowledge in the literature.

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