Primary myocardial disease, diabetes mellitus, and small vessel disease

Zoneraich, Samuel; Silverman, Gerald; Zoneraich, Olga

doi:10.1016/0002-8703(80)90243-4

Cited by 51 publications

(14 citation statements)

References 10 publications

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“…Early studies of cardiac biopsy samples showed significantly higher incidence of small vessel disease in diabetic patients. 32 The microvasculature is dynamically regulated by a combination of endogenous pro-versus antiangiogenic forces, [33][34][35] including EC impairment, decreased local presence of survival factors and increased local presence of anti-angiogenic factors. [33][34][35][36] Decreased coronary reserve is a well-recognized contributor to the early incidence of cardiac abnormalities in diabetic patients.…”

Section: Discussionmentioning

confidence: 99%

Role of mitochondrial dysfunction in hyperglycaemia-induced coronary microvascular dysfunction: Protective role of resveratrol

Joshi

Williams

Horlock

et al. 2015

Diabetes and Vascular Disease Research

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Microvascular complications are now recognized to play a major role in diabetic complications, and understanding the mechanisms is critical. Endothelial dysfunction occurs early in the course of the development of complications; the precise mechanisms remain poorly understood. Mitochondrial dysfunction may occur in a diabetic rat heart and may act as a source of the oxidative stress. However, the role of endothelial cell-specific mitochondrial dysfunction in diabetic vascular complications is poorly studied. Here, we studied the role of diabetes-induced abnormal endothelial mitochondrial function and the resultant endothelial dysfunction. Understanding the role of endothelial mitochondrial dysfunction in diabetic vasculature is critical in order to develop new therapies. We demonstrate that hyperglycaemia leads to mitochondrial dysfunction in microvascular endothelial cells, and that mitochondrial inhibition induces endothelial dysfunction. Additionally, we show that resveratrol acts as a protective agent; resveratrol-mediated mitochondrial protection may be used to prevent long-term diabetic cardiovascular complications.

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Section: Discussionmentioning

confidence: 99%

Role of mitochondrial dysfunction in hyperglycaemia-induced coronary microvascular dysfunction: Protective role of resveratrol

Joshi

Williams

Horlock

et al. 2015

Diabetes and Vascular Disease Research

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show abstract

“…These factors include small vessel disease, abnormal myocardial capillaries and small intramural arteries, endothelial dysfunction, increased platelet aggregability, and hyperfibrinogenemia (25)(26)(27). According to previous studies with different diagnostic approaches to detect myocardial ischemia or perfusion defects during stress, if coronary angiography is used as the gold standard (28 -33), there is a subset of diabetic patients with a false positive stress myocardial contrast echocardiographic study.…”

Section: Discussionmentioning

confidence: 99%

Detection of Coronary Artery Disease in Asymptomatic Patients With Type 2 Diabetes Mellitus

Scognamiglio

Negut

Ramondo

et al. 2006

Journal of the American College of Cardiology

209

135

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An "aggressive" diagnostic approach, requiring coronary angiography in asymptomatic DM2 patients with < or =1 associated RF for CAD and abnormal MCE, identified patients with a subclinical CAD characterized by a more favorable angiographic anatomy. The criterion of > or =2 RFs did not help to identify asymptomatic patients with a higher prevalence of CAD and is only related to a more severe CAD with unfavorable coronary anatomy.

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“…In fact, impaired glucose metabolism and diabetes alter the myocardial metabolism reducing cardiac susceptibility to ischemic stimuli and cardiac performance and therefore, in diabetic patients with coronary artery disease, the episodes of transient myocardial ischemia coupled with chronic myocardial hypoperfusion due to diffuse distribution of atherosclerosis may cause a progressive decline of left ventricular function [29]. Given the metabolic alterations of the diabetic heart at rest and during episodes of myocardial ischemia a therapeutic approach aimed at an improvement of cardiac metabolism through manipulations of the utilization of metabolic substrates should result in an improvement of myocardial ischemia and of left ventricular function [30].…”

Section: Discussionmentioning

confidence: 99%

Effect of free fatty acid inhibition on silent and symptomatic myocardial ischemia in diabetic patients with coronary artery disease

Marazzi

Wajngarten

Vitale

et al. 2007

International Journal of Cardiology

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Primary myocardial disease, diabetes mellitus, and small vessel disease

Cited by 51 publications

References 10 publications

Role of mitochondrial dysfunction in hyperglycaemia-induced coronary microvascular dysfunction: Protective role of resveratrol

Role of mitochondrial dysfunction in hyperglycaemia-induced coronary microvascular dysfunction: Protective role of resveratrol

Detection of Coronary Artery Disease in Asymptomatic Patients With Type 2 Diabetes Mellitus

Effect of free fatty acid inhibition on silent and symptomatic myocardial ischemia in diabetic patients with coronary artery disease

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