Primary malignant schwannoma of the Gasserian ganglion

Hedeman, Lynn S.; Lewinsky, Bernard S.; Lochridge, G. Kress; Trevor, Richard

doi:10.3171/jns.1978.48.2.0279

Cited by 60 publications

(18 citation statements)

References 14 publications

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“…These 29 articles provided 35 cases, to which we added 1 additional case from our institu tion. 1,2,[4][5][6][7][8]10,11,[14][15][16][17][18][19][20][21]24,[26][27][28][29][30][32][33][34][35][36][37] The complete results of our analysis of 36 cases are detailed in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…14,33,34 In our review we found a wide vari ety of presenting symptoms. The majority of patients pre sented with altered facial sensation and/or facial pain dis tributed along the affected divisions.…”

Section: Clinical Presentationmentioning

confidence: 94%

“…The majority of patients pre sented with altered facial sensation and/or facial pain dis tributed along the affected divisions. 1,4,6,7,11,14,16,17,20,21,24,33,37 Furthermore, weakness of the mastication muscles was also seen in a number of patients. 17,20,33 The involvement of other cranial nerves was relatively common among the population we studied, and we found that it was typically due to spread of malignant tumor through the cavernous sinus and other intracranial or extracranial compartments.…”

Section: Clinical Presentationmentioning

confidence: 99%

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Malignant peripheral nerve sheath tumors of the trigeminal nerve: a systematic review of 36 cases

Schmidt¹,

Yick²,

Boghani³

et al. 2013

FOC

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Object Malignant peripheral nerve sheath tumors (MPNSTs) are a rare form of malignancy arising from the Schwann cells of peripheral nerves. MPNSTs of the trigeminal nerve are exceptionally rare, with only a handful of reports in the literature. These tumors are typically very aggressive, resulting in significant patient morbidity and a generally grim prognosis. Most current reports suggest that radical resection with radiation therapy offers the best benefit. In this study, the authors systematically reviewed the world English-language literature on MPNSTs of the trigeminal nerve to analyze the presentations, treatment options, and outcomes for patients with this disease. Methods A literature search for MPNSTs of the trigeminal nerve confined to nonanimal, English-language articles was conducted utilizing the PubMed database, with additional cases chosen from the references of selected articles. Only cases of confirmed MPNSTs of the trigeminal nerve or its peripheral branches, based upon surgical, pathological, or radiological analysis, were included. Results From the literature search, 29 articles discussing 35 cases of MPNSTs of the trigeminal nerve were chosen. With the addition of 1 case from their own institution, the authors analyzed 36 cases of trigeminal MPNSTs. The average age of onset was 44.6 years. These tumors were more commonly seen in male patients (77.1%). The gasserian ganglion was involved in 36.1% of the cases. Of the cases in which the nerve distribution was specified (n = 25), the mandibular branch was most commonly involved (72.0%), followed by the maxillary branch (60.0%) and the ophthalmic branch (32.0%), with 44.0% of patients exhibiting involvement of 2 or more branches. Altered facial sensation and facial pain were the 2 most commonly reported symptoms, found in 63.9% and 52.8% of patients, respectively. Mastication difficulty and diplopia were seen in 22.2% of patients, facial weakness was seen in 19.4%, and hearing loss was present in 16.7%. With regard to the primary treatment strategy, 80.6% underwent resection, 16.7% underwent radiation therapy, and 2.9% received chemotherapy alone. Patients treated with complete resection followed by postoperative radiation therapy had the most favorable outcomes, with no patients showing evidence of disease recurrence with a mean follow-up of 34.6 months. Patients treated with incomplete resection followed by postoperative radiation therapy had more favorable outcomes than patients treated with incomplete resection without radiation therapy or radiation therapy alone. Conclusions Trigeminal MPNSTs most commonly present as altered facial sensation or facial pain, although they exhibit a number of other clinical manifestations, including the involvement of other cranial nerves. While a variety of treatment options exist, due to their highly infiltrative nature, aggressive resection followed by radiation therapy appears to offer the greatest chance of recurrence-free survival.

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Section: Resultsmentioning

confidence: 99%

Section: Clinical Presentationmentioning

confidence: 94%

Section: Clinical Presentationmentioning

confidence: 99%

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Malignant peripheral nerve sheath tumors of the trigeminal nerve: a systematic review of 36 cases

Schmidt¹,

Yick²,

Boghani³

et al. 2013

FOC

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“…Growth within the cavernous sinus may further lead to dysfunction of cranial nerves III, IV, and VI, and enlargement within the prepontine cistern may lead to compressive effects on cranial nerves VII, VIII, and IX. 3,4 Trigeminal schwannomas are a type of peripheral intracranial nerve sheath tumor that develop at the skull base and originate from the Schwann cells. Schwann cells are a type of glial cell that helps protect the transmission of messages and instructions by neurons in the peripheral nervous system.…”

Section: Case Reportmentioning

confidence: 99%

Trigeminal nerve schwannoma

et al. 2016

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“…Tumors of Meckel's cave involving the Gasserian ganglion are usually benign and are either meningioma or trigeminal neurinomas (1,8). They represent less than 0.5% of all intracranial tumors (4).…”

Section: Introductionmentioning

confidence: 99%

Surgical treatment of rare metastatic tumor in Meckel’s Cave: a case report

Rădoi¹,

Stefanescu²,

Vakilnejad³

et al. 2017

Romanian Neurosurgery

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Abstract:Objectives: Metastases in Meckel's cave are a rare tumor entity, but they should be considered in patients with a known primary malignancy and who complain of trigeminal neuralgia. Methods: The case of a patient with a left trigeminal neuralgia caused by a metastatic tumor involving the Meckel's cave and Gasserian ganglion is reported. Preoperative symptoms included headache, trigeminal hyperesthesia and facial pain. Results: The patient underwent microsurgical resection of the tumor, obtaining a histological diagnosis and a resolution of the pain. Trigeminal motor function was preserved. Conclusion: The best treatment for tumors of Meckel's cave, including metastases, is complete microsurgical removal. Although good results have been reported with radiosurgery, this treatment should be reserved only for nonresectable and residual tumors.

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Primary malignant schwannoma of the Gasserian ganglion

Cited by 60 publications

References 14 publications

Malignant peripheral nerve sheath tumors of the trigeminal nerve: a systematic review of 36 cases

Malignant peripheral nerve sheath tumors of the trigeminal nerve: a systematic review of 36 cases

Trigeminal nerve schwannoma

Surgical treatment of rare metastatic tumor in Meckel’s Cave: a case report

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