The diagnosis, radiographic features, clinical presentation, and treatment of two cases of primary malignant schwannoma of the Gasserian ganglion are discussed. Radiographic differentiation from trigeminal neurinoma is not possible; however, erosion of the foramina favors a diagnosis of malignancy. Radiation therapy was successful in the management of both cases and is recommended for extensive lesions.

Colloid cysts are relatively rare benign tumors comprising less than 2% of all intracranial mass lesions. However, since the advent of computed tomography of the head, these tumors are being recognized more frequently, occasionally before their symptomatic presentation. Much controversy remains as to the true cells of origin and pathogenesis of these cysts. Although a neuroepithelial origin has become increasingly accepted, Rathke cleft cysts, ectopic respiratory tissue, and other endodermal sources have been postulated. The first familial occurrence in middle-aged identical twin brothers was cited recently in the literature. Described here are the first reports of symptomatic colloid cysts in two nontwin brothers, lending further support to the potential for genetic expression of neuroepithelial cysts. Also included are preoperative computed axial tomographic images, histopathologic photomicrographs with case descriptions and comparisons, and suggestions to elucidate further the development and presentation of colloid cysts.

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✓ A chronic clinicopathological study in 43 mongrel dogs evaluates the therapeutic effect of microcirculatory augmentation, an anti-edema agent, catecholamine (CA) receptor blockers, and a CA synthesis inhibitor. Results showed a high degree of clinical protection conferred by phenoxybenzamine, an alpha-adrenergic receptor blocker, and a lesser degree of protection from haloperidol, a domaminergic blocker, and low molecular weight dextran. Alpha-methyltyrosine given post-injury and steroids were of no therapeutic value. There was a correlation between microscopic white matter protection and clinical result. The presence of central gray necrosis was rather constant irrespective of therapy or clinical result.