Primary Malignant Fibrous Histiocytoma of the Lung

Rzyman, Witold; Jaskiewicz, K; Murawski, Maciej; Sternau, Adam; Marjański, Tomasz; Karmolinski, Andrzej; Dziadziuszko, Rafał

doi:10.1055/s-2006-955874

Cited by 9 publications

(10 citation statements)

References 12 publications

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“…We must take into consideration the fact that primary MFH of the lung is extremely rare (0,2% of the pulmonary neoplasms) with only about 50 cases been reported in the literature [4]. There must be no evidence of another primary site as determined by physical and radiologic exam before a MFH can be considered a lung primary tumor.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, survival after complete surgical resection in cases of primary lung MFH has been reported to be better than for other pulmonary sarcomas [4]. Many clinicopathologic factors are significally related to disease free specific survival (DSS) and metastasis free survival (MFS), including age, tumor size-depth, classification stage, histologic type and grade.…”

Section: Discussionmentioning

confidence: 99%

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Primary Malignant Fibrous Histiocytoma of the Lung: A Case Report

Tsangaridou

Papamihalis²,

Stathopoulos³

et al. 2010

Case Reports in Medicine

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Primary malignant fibrous histiocytoma (MFH) of the lung is extremely rare although it is among the most common soft tissue sarcomas in adults. Surgery is the primary mode of therapy, with high rates of local and distant recurrence, while radiation therapy appears to be a very useful adjunct, decreasing local relapse. We report a case of primary malignant fibrous histiocytoma of the lung. Fourteen years after surgical resection, the patient is still alive although with multiple metastatic lesions throughout his body.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Primary Malignant Fibrous Histiocytoma of the Lung: A Case Report

Tsangaridou

Papamihalis²,

Stathopoulos³

et al. 2010

Case Reports in Medicine

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“…[1][2][3] Although a study reported that 33% of patients who received combination chemotherapy showed partial response, MFH is usually resistant to chemotherapy or radiotherapy. 3,5 A previous study revealed a 5-year survival rate of 58% and a 10-year survival rate of 38%. 6 Surgical resection is the best treatment option when the disease is limited.…”

Section: Discussionmentioning

confidence: 97%

“…6 Surgical resection is the best treatment option when the disease is limited. 5,7 A few cases of MFH arising from the pleura and diaphragm have shown aggressive clinical features. 8,9 However, the bronchus and trachea are extremely rare sites for MFH, and to our knowledge, there are only 10 cases reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

Endobronchial Malignant Fibrous Histiocytoma: Case Report of an Unusual Presentation and Palliative Flexible Bronchoscopic Resection

et al. 2012

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Primary malignant fibrous histiocytoma (MFH) of the lung is a very rare neoplasm that usually presents as a parenchymal mass. Here we report an unusual case of primary MFH of the bronchus, showing relatively benign clinical features. We performed a palliative resection via flexible bronchoscopy, using a polypectomy snare. The patient has survived for over 2 years after being diagnosed with an endobronchial mass, later found to be MFH, and 14 months post-debulking. There is a possibility that endobronchial MFH has a more favorable prognosis than MFH of other origins. If this is true, interventional bronchoscopy can be a reasonable option for non-operable cases of MFH.

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“…MFH is a soft tissue sarcoma mainly occuring in the soft tissues, especially in the extremities and trunk. MFH is an aggressive malignancy with high potential of local recurrence and distant metastasis3-5. Surgery is treatment of choice even with recurrence and metastasis6.…”

Section: Introductionmentioning

confidence: 99%