Endobronchial Malignant Fibrous Histiocytoma: Case Report of an Unusual Presentation and Palliative Flexible Bronchoscopic Resection

Kim, Jung-Hyun; Cho, Sang-Ho; Kim, Min Jung; Lee, Ji‐Hyun; Jeong, Hye-Cheol

doi:10.4187/respcare.01996

Cited by 7 publications

(5 citation statements)

References 23 publications

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“…Ipsilateral pleural effusion can occur in 20% of the patients [5], and endobronchial lesions have also been reported [6]. Without intending to make a generalized statement about FDG uptake in primary pulmonary MFH because it is a type of tumor that is rarely seen in the lungs, in our case, the SUVmax was 9.7.…”

Section: Discussionmentioning

confidence: 75%

Primary Pulmonary Malignant Fibrous Histiocytoma

et al. 2017

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Malignant fibrous histiocytoma (MFH) cases are classified within the group of nonclassified sarcomas. The etiopathogenesis is unclear; however, MFH commonly develops in scar tissue and in areas exposed to radiation. MFH is the most common soft tissue sarcoma in adults and may be borne in the lungs, chest wall, mediastinum, or other tissues. Primary MFH of the lung constitutes less than 0.2% of all pulmonary neoplasms; thus, an optimal treatment strategy has not yet been elucidated. We aimed to report a case of MFH of the lung with subsequent treatment administration.

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Section: Discussionmentioning

confidence: 75%

Primary Pulmonary Malignant Fibrous Histiocytoma

et al. 2017

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“…The multicenter, single-agent doxorubicin and phase III clinical trial of doxorubicin–ifosfamide chemotherapy in Europe indicates a higher tumor response and overall survival (OS) ( 16 ) (OR 9.90, 95% HR 0.44, 95%). Therefore, gemcitabine/docetaxel chemotherapy may be a good option for patients with doxorubicin or ifosfamide failure ( 17 ). According to the retrospective study of Jee Hung Kim ( 17 ), the MFH/UPS efficiency is 50%.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, gemcitabine/docetaxel chemotherapy may be a good option for patients with doxorubicin or ifosfamide failure ( 17 ). According to the retrospective study of Jee Hung Kim ( 17 ), the MFH/UPS efficiency is 50%. However, these chemotherapy regimens are highly toxic which may lead to treatment failure.…”

Section: Discussionmentioning

confidence: 99%

Primary giant cell malignant fibrous histiocytoma of the lung: a rare case report and literature review

Xu¹,

Qu²,

Yu³

2020

Transl Cancer Res TCR

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Malignant fibrous histiocytoma (MFH) usually involves the extremities. Among MFH, primary giant cell malignant fibrous histiocytoma of the lung is extremely rare, with nonspecific symptoms. A 45-year-old woman was first diagnosed as sclerosing hemangioma due to long-term persistent cough and blood in sputum. One year later, the condition became worse and hemoptysis occurred. At the second visit, the same mass was found to be larger than the previous one. Lobectomy was performed and the primary giant cell MFH of the lung was confirmed. Renal and sacrum metastasis occurred six months after operation.The efficacy of hypofractionation radiotherapy and immuno targeted follow-up therapy is significant. At present, there is no standard treatment plan. For the patients in the early stage, surgical resection is the main treatment method; but for the patients in the middle and late stage, the treatment is relatively single. So early diagnosis and treatment are particularly important, In this paper, we first report the use of pembrolizumab combined with anlotinib in a patient with advanced giant cell MFH of the lung, with failure of routine treatment. The development of the disease had successfully delayed and satisfactory results were observed. Therefore, it is very necessary to emphasize the choice of treatment plan to improve the prognosis of patients.

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“…The majority of patients die within a period of 1 to 72 months. Endobronchial masses showed more favorable prognosis compare to other origins 8…”

Section: Introductionmentioning

confidence: 90%

“…Clinical presentations in pulmonary tumors, as with other types of lung cancers, depends more on the tumor location rather than the histological type. Primary pulmonary sarcomas often present as a large peripheral or hilar well-circumscribed mass, and may present as an endobronchial tumor in 10% of cases 8. The majority of patients present with symptoms of cough, chest pain, hemoptysis, or dyspnea.…”

Section: Introductionmentioning

confidence: 99%

Primary pulmonary undifferentiated pleomorphic sarcoma (PPUPS)

Qorbani

Nelson

2019

Autops. Case Rep.

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Undifferentiated pleomorphic sarcoma (UPS) is a high-grade pleomorphic neoplasm with no identifiable line(s) of differentiation using currently available diagnostic techniques. Therefore, it is essentially a diagnosis of exclusion, which requires generous tissue sampling, adequate contextually interpreted immunohistochemistry, and relevant molecular studies. UPS is a common soft tissue sarcoma (historically one of the entities referred to as malignant fibrous histiocytoma (MFH)), which can develop in various organs, but lung involvement is usually due to metastasis. Primary Pulmonary UPS (PPUPS) is exceptionally rare and here we present a 66-year-old man who presented with anemia and weight loss, found to have a 17 cm right lung mass with invasion to the chest wall and diaphragm. Extensive sampling and immunohistochemistry studies failed to reveal any line of differentiation. Upon exclusion of a possible extrapulmonary origin, a diagnosis of PPUPS was rendered. In addition, we reviewed all 84 previously reported cases of PPUPS/PPMFH in the literature since 1979 and summarized the clinical information.

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Endobronchial Malignant Fibrous Histiocytoma: Case Report of an Unusual Presentation and Palliative Flexible Bronchoscopic Resection

Cited by 7 publications

References 23 publications

Primary Pulmonary Malignant Fibrous Histiocytoma

Primary Pulmonary Malignant Fibrous Histiocytoma

Primary giant cell malignant fibrous histiocytoma of the lung: a rare case report and literature review

Primary pulmonary undifferentiated pleomorphic sarcoma (PPUPS)

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