Primary Leiomyosarcoma of the Great Saphenous Vein: Case Report and Review of the Literature

Cangiano, Rodolfo; Orlandino, Gianfranco; Patitucci, Giuseppe; Lembo, Fedele; Fabrizio, Tommaso

doi:10.1016/j.avsg.2016.04.021

Cited by 10 publications

(24 citation statements)

References 37 publications

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“…Leiomyosarcomas are malignant neoplasms that represent around 6% of all soft tissue sarcomas [6] . Those SMS involving major vessels comprise less than 2% of all leiomyosarcomas [1] , [4] , [5] .…”

Section: Clinical Discussionmentioning

confidence: 99%

“…Nonetheless, some cases have been reported involving the GSV in the lower extremities [1] , [2] . A mean age of 55 to 61 years had been described for those patients with a GSV leiomyosarcoma [1] , [6] , [8] . However, due to the few reported cases, most of the demographic data retrieved remain without statistical significance [6] .…”

Section: Clinical Discussionmentioning

confidence: 99%

“…They represent less than 2% of all leiomyosarcomas and occur five times more frequently in veins than arteries [1] , [4] , [5] . These neoplasms are most commonly associated with the inferior vena cava (IVC), followed by a few cases arising from the great saphenous vein (GSV) [4] , [6] . They present as a slowly growing painless mass [1] , [4] , [6] .…”

Section: Introduction and Importancementioning

confidence: 99%

“…These neoplasms are most commonly associated with the inferior vena cava (IVC), followed by a few cases arising from the great saphenous vein (GSV) [4] , [6] . They present as a slowly growing painless mass [1] , [4] , [6] . Due to their insidious and asymptomatic presentation, their diagnosis and treatment are frequently delayed resulting in poor prognosis, with distant metastases found in 10 to 25% of patients at the time of diagnosis [5] .…”

Section: Introduction and Importancementioning

confidence: 99%

See 3 more Smart Citations

Primary leiomyosarcoma of the great saphenous vein: A case report

Tresgallo-Parés

Virgilio-Salgado

Torres-Lugo

et al. 2021

International Journal of Surgery Case Reports

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Section: Clinical Discussionmentioning

confidence: 99%

Section: Clinical Discussionmentioning

confidence: 99%

Section: Introduction and Importancementioning

confidence: 99%

Section: Introduction and Importancementioning

confidence: 99%

See 2 more Smart Citations

Primary leiomyosarcoma of the great saphenous vein: A case report

Tresgallo-Parés

Virgilio-Salgado

Torres-Lugo

et al. 2021

International Journal of Surgery Case Reports

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“…Das venöse Leiomyosarkom betrifft am häufigsten die Vena cava inferior (mehr als 50 % der Fälle) und in absteigender Häufigkeit die Vena renalis und Vena femoralis, sehr selten, in ca. 10 % der Fälle, die Vena saphena magna [6].…”

Section: Vaskuläre Leiomyosarkomeunclassified

Leiomyosarkom der Vena saphena magna – der seltene Fall

2021

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ZusammenfassungWir berichten über eine bisher gesunde 58-jährige Patientin, die sich mit stärksten persistierenden lokalen Schmerzen am distalen medialen Oberschenkel rechts in unserer Klinik vorstellte. Begleitsymptome wie lokale Schwellung oder Rötung lagen nicht vor. Sonografisch zeigte die Vena saphena magna im angegebenen Schmerzbereich am distalen Oberschenkel eine suspekte isolierte Ektasie mit einer umschriebenen echoarmen, solid erscheinenden Gefäßwandläsion bei sonst im übrigen Gefäßverlauf unauffälligem Sonografiebefund.Nach operativer Resektion wurde die Diagnose eines mäßig differenzierten vaskulären Leiomyosarkoms gestellt.Weichteilsarkome sind verglichen mit anderen Tumorerkrankungen sehr selten.Das venöse Leiomyosarkom betrifft bevorzugt die Vena cava inferior, sehr selten die Vena saphena magna. Für die Prognose ist eine frühzeitige Diagnose entscheidend. Häufig liegt bei Diagnosestellung bereits eine Metastasierung mit entsprechend ungünstiger Prognose vor.Bei unklaren Symptomen und Sonografiebefunden im Bereich des Gefäßsystems sollte, trotz seltenen Vorkommens, auch an eine neoplastische Erkrankung gedacht werden.

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Combined double superficial circumflex iliac artery perforator flap with lymphatic tissue preservation and lymphovenous anastomosis for lymphatic sequelae prevention in thigh defect reconstruction: A case report

et al. 2021

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The thigh region is often site of soft tissue tumors development. Leiomyosarcoma, in particular, is a malignant tumor that, if not promptly treated, presents a growth rate that often results in large masses. The safest treatment in these cases is margin-free extensive surgical resection. This leads to rather large defects that in a delicate region, such as the medial thigh, implies a series of possible complications from the lymphatic point of view. In this region run major lymphatic vessels, appointed to drain the whole leg. Now that one is aware of this issue, the best solution is trying to obtain an efficient reconstruction and preventing the development of postoperative lymphedema and lymphocele. Here, we present a case of great saphenous vein leiomyosarcoma resection in the right medial thigh reconstructed by means of two superficial circumflex iliac artery perforator (SCIP) flaps with lymphatic tissue preservation, combined with preventive lymphovenous anastomosis (LVA). A 67-years-old woman presented a 22 × 16 cm soft tissue defect after the surgical excision. To fill the defect, we resorted to a larger SCIP flap island, supplied by both the superficial and deep branches of the superficial circumflex iliac artery anastomosed in perforator-to-perforator fashion, and to a smaller SCIP flap island supplied only by the superficial branch. Before surgery, the lymphatic vessels running in the flaps area were identified with indocyanine green lymphography and were carefully preserved during the harvest procedure. They were then transferred with the surrounding tissue and orientated in order to match the lymphatic flow direction, providing further fluid drainage. To boost the lymphatic drainage, an LVA was also performed at the superior-edge-of-the-knee incision point joining a functioning lymphatic vessel to a nearby reflux-free vein. The postoperative course was uneventful and at 7 months follow-up, the patient showed good cosmetic and functional outcomes with no swelling and no signs of tumor relapse. This report provides a series of technical insights and adds further evidence to support the efficacy of this procedure for management of soft tissue defects in the medial thigh region.Mario F. Scaglioni and Matteo Meron should be considered as first co-authors.

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Primary Leiomyosarcoma of the Great Saphenous Vein: Case Report and Review of the Literature

Cited by 10 publications

References 37 publications

Primary leiomyosarcoma of the great saphenous vein: A case report

Primary leiomyosarcoma of the great saphenous vein: A case report

Leiomyosarkom der Vena saphena magna – der seltene Fall

Combined double superficial circumflex iliac artery perforator flap with lymphatic tissue preservation and lymphovenous anastomosis for lymphatic sequelae prevention in thigh defect reconstruction: A case report

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