Primary Intraspinal Cervical Melanoma

Bidziński, J; Kroh, H; Leszczyk, C; Bojarski, P

doi:10.1007/s007010070066

Cited by 10 publications

(6 citation statements)

References 4 publications

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“…The course of case 2 is difficult to determine as the patient was already mentally impaired. This is consistent with the literature on spinal [6,12,17,25] as well as cerebral [2,13] manifestations. Spinal manifestations seem to have the longest courses prior to diagnosis.…”

Section: Clinical Presentationsupporting

confidence: 93%

“…In one case report of a primary melanocytic lesion of the pineal region, almost complete surgical removal was followed by whole brain irradiation and chemotherapy with lomustine and dibromodulcitol [24]. Primary melanocytic lesions of the spine are treated similarly with surgical removal of the tumour, in most reports followed by regional radiotherapy therapy of 30 to 60 Gy [6,17,28]. Some authors recommend additional intrathecal chemotherapy [33].…”

Section: Therapeutic Optionsmentioning

confidence: 99%

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Primary Melanocytic Lesions of the CNS: Report of Five Cases

Freudenstein

Wagner

Bornemann

et al. 2004

Zentralbl Neurochir

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Primary melanocytic tumours of the central nervous system (CNS) form a rare entity which is histologically and clinically distinct from metastatic cutaneous or retinal malignant melanoma. They can be classified into diffuse melanocytosis (diffuse melanosis), malignant melanoma and benign melanocytoma with a small number of intermediate variants. In this paper, 5 cases treated neurosurgically in our department for spinal or cerebral primary CNS malignant melanoma are reported. Primary tumors and further metastases were ruled out. Radiological, histological and clinical features are discussed. Compared to metastatic disease, primary CNS malignant melanoma shows a more benign clinical course with long-term tumour control and a good quality of life. A review of the literature which mainly consists of individual case reports, confirms this assessment. Although therapeutic experience for primary melanocytic lesions of the CNS is based on a small number of published cases, prognosis seems highly dependent on complete tumour resection. Adjuvant radiation seems to be of additional therapeutic benefit. Except for meningeosis melanomatosa chemotherapy must be regarded as experimental. Unfortunately, a standardised therapy concept is still lacking.

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Section: Clinical Presentationsupporting

confidence: 93%

Section: Therapeutic Optionsmentioning

confidence: 99%

Primary Melanocytic Lesions of the CNS: Report of Five Cases

Freudenstein

Wagner

Bornemann

et al. 2004

Zentralbl Neurochir

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“…Larson et al [3] reported 7 years as the life expectancy after surgery and radiotherapy. Moreover, other long-term survival periods of treated primary spinal cord melanoma cases have been shown in the literature [10,11]. The survival period is still unpredictable, but there have been some reports that total excision and postoperative radiotherapy may extend the survival period.…”

Section: Discussionmentioning

confidence: 99%

Primary Spinal Cord Melanoma in Thoracic Spine with Leptomeningeal Dissemination and Presenting Hydrocephalus

Jeong

Lee

You

et al. 2013

Brain Tumor Res Treat

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Primary spinal cord melanoma is a rare central nervous system malignant tumor. Usually it resembles an intradural extramedullary (IDEM) nerve sheath tumor or melanoma. We experienced a patient with upper thoracic primary IDEM spinal cord melanoma who was diagnosed to be with hydrocephalus and without intracranial lesions. Initial symptoms of the patient were related to the hydrocephalus and the primary spinal cord melanoma was diagnosed eight months later. At the first operation, complete resection was impossible and the patient refused additional radiotherapy or chemotherapy. At 22 months after surgery, the patient revisited our institution with recurrent both leg weakness. Leptomeningeal dissemination was present in the whole spinal cord and only partial resection of tumor was performed. The symptoms slightly improved after surgery. Primary spinal cord melanoma is extremely rare but complete resection and additional radiotherapy or chemotherapy can prolong the disease free interval. Hydrocephalus or signs of increased intracranial pressure may be the diagnostic clue of spinal cord malignancy and progression.

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“…The patient in our case was treated with radiotherapy and interferon therapy. Although long-term observations suggest that the prognosis is relatively good in patients with malignant melanoma of the spinal cord as long-lasting recovery can be obtained, even after incomplete surgical removal, 4,17,23 radical removal of the tumor should be followed by radiotherapy because of unexpected malignant nature of this tumor. Therefore, appropriate casespecific therapy involving surgery, radiotherapy, and chemotherapy should be planned on the basis of prompt diagnosis.…”

Section: Discussionmentioning

confidence: 96%