Primary gastrointestinal Non Hodgkin′s lymphoma chemotherapy alone an effective treatment modality: Experience from a single centre in India

Raina, Vinod; Sharma, Atul; Vora, Amish; Shukla, N.K.; Deo, Svs; Dawar, Ramesh

doi:10.4103/0019-509x.25773

Cited by 15 publications

(2 citation statements)

References 17 publications

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“…In our study, 40% of patients, presented with acute/subacute intestinal obstruction and 7% with intestinal perforation requiring surgical resection which was bit more in comparison with the previously published studies which could be due to late presentation. 18 , 20 Abdominal pain was present in 32% and B symptoms in 36% of the patients.…”

Section: Discussionmentioning

confidence: 97%

Primary Intestinal Lymphoma: Clinicopathological Characteristics of 55 Patients

Malipatel¹,

Patil²,

Rout³

et al. 2021

Euroasian Journal of Hepato-Gastroenterology

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A bstract Introduction Gastrointestinal (GI) tract is the most common site of extranodal lymphoma accounting for 30–40% of the cases. In Western countries, stomach is the most common site of GI lymphoma, whereas in the Middle East and Mediterranean countries, small intestine is commonly involved. Studies about primary intestinal lymphoma (PIL) are heterogeneous in anatomical distribution, presentation, and histological subtypes. The present study was aimed at studying the anatomical distribution, histological subtypes, and clinical characteristics at tertiary care centers. Materials and methods The present study was retrospective, conducted between 2006 and 2020. Patient's data were collected from institutional medical records. PIL was diagnosed by Lewin's criteria. After histological diagnosis, PIL was classified as per the World Health Organization (WHO) criteria and staging was done according to the Ann Arbor classification as modified by Musshoff. Results A total of 941 lymphoma cases were diagnosed during the study period between 2006 and 2020 consisting of 238 Hodgkin's lymphoma and 703 non-Hodgkin's lymphoma (NHL) cases. PIL constituted 5.8% of all lymphoma cases (55 out of 941) and 50.9% (55 of 108) of all primary GI lymphoma. Median age at diagnosis was 44 years and comprised predominantly males (85.45%). Diffuse large B-cell lymphoma (DLBCL) and mucosa-associated lymphoid tissue (MALT) lymphoma were the most common histological subtype (78%) seen. Two patients with primary Hodgkin's lymphoma involving the intestine were seen. T-cell lymphoma was seen in three (5.4%) patients. Ileocecal region was the most common site involved (27%). The common presenting complaints were intestinal obstruction (40%) requiring surgical resection and abdominal pain (32%). Majority of the patients presented in the early stages (I and II). Conclusion Our study demonstrates the pattern of distribution and various histological subtypes of PIL including the rare variants like primary intestinal Hodgkin's lymphoma. Relatively more number of patients presented with intestinal obstruction requiring surgery in comparison with other studies. How to cite this article Malipatel R, Patil M, Rout P, et al . Primary Intestinal Lymphoma: Clinicopathological Characteristics of 55 Patients. Euroasian J Hepato-Gastroenterol 2021;11(2):71–75.

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Section: Discussionmentioning

confidence: 97%

Primary Intestinal Lymphoma: Clinicopathological Characteristics of 55 Patients

Malipatel¹,

Patil²,

Rout³

et al. 2021

Euroasian Journal of Hepato-Gastroenterology

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“…Pediatric PGILs most commonly involve the small and the large gut, in contrast to adults where the stomach is the most common site of involvement. [ 18 19 ] Most of the papers have shown that ileocoecal junction to be the most common site of involvement; followed by the small intestine. [ 7 15 ] Low-grade lymphomas such as MALToma and IPSID have not been reported in the pediatric age group.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological study of primary pediatric gastrointestinal lymphomas

Ghosh

Sengupta

Barman

et al. 2021

J Indian Assoc Pediatr Surg

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Background: Primary gastrointestinal lymphomas (PGIL) are uncommon in children and account for <5% of all pediatric malignancies. The objective of our study was to analyze the prognostic factors of pediatric PGILs with reference to its histological subtypes, stage, and outcomes using immunohistochemistry. Materials and Methods: Twenty cases were studied over 11 years. Clinicopathological profiles, histological details, and immunohistochemical (IHC) profiles were analyzed. Results: The mean age at the presentation was 6 years. Using IHC stains (CD CD10, CD19, CD20, CD3, terminal deoxynucleotidyl transferase, BCL 2 and 6, PAX 5, and MUM1), diffuse large B-cell lymphoma (DLBCL) was most prevalent (45%), followed by Burkitt lymphoma (35%) and lymphoblastic lymphoma (20%). DLBCLs (9) were classified using the Han's algorithm. Six were activated B-cell and 3 were germinal center B-cell subtypes. The cases of lymphoblastic lymphoma and those in Stage I disease had the best prognosis. Conclusion: Pediatric PGILs have variable presentation, outcomes, and diverse treatment modalities depending on the histological subtypes. A panel of IHC stains can be a useful adjunct for the categorization and prognosis of pediatric PGILs.

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Primary Non-Hodgkin’s Lymphoma of the Rectum

Güney¹,

Başaran²,

Aksakallı

et al. 2007

Oncol Res Treat

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Primary rectal lymphoma is a very uncommon disease, therefore, it has received little attention in the literature. Because of their rarity, rectal lymphomas are generally included in the group of large intestine lymphomas. Case Report: We report here a case of primary rectal B-cell lymphoma in a 67-year-old woman. The tumor was originally located in the rectum without evidence of any other lymphoma-involved organ. Histological findings revealed diffuse large B-cell lymphoma. The clinical stage was IE according to the Ann Arbor system. International prognostic index (IPI) was I (low-intermediate risk). We preferred a non-surgical, organ-sparing treatment which started with chemotherapy followed by radiation. 12 months after the end of therapy, there is no sign of tumor recurrence in our patient. Conclusion: We suggest that histology-specific multidrug chemotherapy followed by radiotherapy seems to be a therapeutic approach that is appropriate fort this rare tumor.

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Primary gastrointestinal Non Hodgkin′s lymphoma chemotherapy alone an effective treatment modality: Experience from a single centre in India

Abstract: BACKGROUND:Gastrointestinal tract (GI) is the most frequently involved extra nodal site in non-Hodgkin's lymphoma

Cited by 15 publications

References 17 publications

Primary Intestinal Lymphoma: Clinicopathological Characteristics of 55 Patients

Primary Intestinal Lymphoma: Clinicopathological Characteristics of 55 Patients

Clinicopathological study of primary pediatric gastrointestinal lymphomas

Primary Non-Hodgkin’s Lymphoma of the Rectum

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